Objective
To estimate the quality and efficacy of the academic thesis of compound anisodine in traumatic optic neuropathies(TON) treatment.
Method
We searched Chinese database last updated in April 2007 for published magazine papers using ldquo;anisodinerdquo; amp; ldquo;optic-neuropathyrdquo; amp; ldquo;traumardquo; or ldquo;blunt trauma rdquo; as key words，and analyzed them using the standard of evidence-based medicine (EBM)．
Result
6 RCTs with a total of 415 eyes included are retrieved , and the OR value is 6.54 with a 95%CI of［4.14，10.35］，P＜0.00001, the difference is sig nificant; subcategory analyses are made and both show significant difference( P＜0.0001).
Conclusion
The existing evidence supports that prognosis of TON is better when compound anisodine are adopt in treatment, and this effect is significant in steroid treatment. Compound anisodine can be used alone for TON treatment. However, because there are only 6 thesis are retrieved and all of them have methodolo gical short-comings，the evidence is not convincing．There is an urgent need of well-planed, large-scale and multiple-center studies to assess the role of compound anisodine in traumatic optic neuropathies treatment．
(Chin J Ocul Fundus Dis,2008,24:103-106)
