This paper reviewed the main achievements in the research on tissue engineering tendon, focusing on major problems concerning the substitute for extracellular matrix (ECM) of tendon, biological characteristics of tendon cells, and tendon cells compounding with ECM substitute. It was concluded the important problems in the study of the tissue engineering having specific reparative functions could be: to prepare the ECM materials suitable for the tendon cells to attach, grow, and function; to establish the tendon cell line whose growth, proliferation, and immunological antigenicity could be modulated and controlled, and simulating the mechanical environment of tendon in vivo, to adopt three-dimensional tendon cell culture method.
