OBJECTIVE:To examine the possibility of allogenic neural retinal transplantation.
METHODS:Donor neural retinal tissue obtained from neonatal mice was implanted into the subretlnal space of 36 adult mice. Twelve recipients were sacrificed at day 6,day 12,and day 18 post-transplantation respectively, and the eyes were enucleated for histologic examination.
RESULTS: The graft was failed to be found but the host retina remained normal in 16.7%(6/36),the graft was found survival and showed further differentiation into rosette formation in the host subretinal space and inner retina in 66.7%(24/36),in the vitreous cavity in 8.3% (3/36). Disastrous granulomatous
inflammation occurred in 8.3%(3/36).
CONCLUSION: Allogenic retina from neonatal mice implanted into the subretinal space might experience immune privilege .in a great extent ,and showed further differentiation during the experimental periods of time.
（Chin J Ocul Fundus Dis,1996,12: 236-238 ）
