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        west china medical publishers
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        find Author "SHEN Kai" 2 results
        • Intestinal Lesions as the Primary Clinical Manifestation of Adult-onset Systemic Epstein-Barr Virus Positive T-cell Lymphoproliferative Disease

          目的 提高對成人系統性Epstein-Barr(EB)病毒陽性T細胞淋巴組織增殖性疾病(ASEBV+T-LPD)腸道病變的認識。 方法 報道2012年3月-10月我院收治的2例以腸道病變為首發表現的ASEBV+T-LPD,并結合3例文獻報道進行分析討論。 結果 2例成人患者以腹瀉為主要表現,伴有發熱、淋巴結長大,初期分別誤診為結核及腸道感染,淋巴結病檢提示多克隆EBER+的T淋巴細胞浸潤,確診ASEBV+T-LPD。例1經3 周期GLIDE方案(吉西他濱+門冬酰胺酶+異環磷酰胺+地塞米松+依托泊苷)化學療法(化療)后疾病進展,死于肺部感染。例2經干擾素聯合抗病毒藥物治療,病情穩定。復習文獻目前僅3例以腸道病變為首發表現的ASEBV+T-LPD被報道,早期均被誤診為炎性腸病或感染,3例均出現腸道穿孔或大出血等并發癥,其中2例死亡。 結論 成人系統性EB病毒陽性T細胞淋巴組織增殖性疾病的腸道病變較為罕見,容易誤診為結核及炎性腸病。部分患者病情進展迅速,可出現腸道穿孔及消化道大出血等致死性并發癥,死亡率高,預后差。確診本病需密切結合臨床和病理學檢查。常規化療及抗病毒治療僅部分有效,不能維持長期緩解。

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        • Common pedicle screw placement under direct vision combined with dome shaped decompression via small incision for double segment thoracolumbar fracture with nerve injury

          Objective To determine the feasibility, safety, and efficacy of common pedicle screw placement under direct vision combined with dome shaped decompression via small incision for double segment thoracolumbar fracture with nerve injury. Methods A retrospective analysis was performed on the clinical data of 32 patients with double segment thoracolumbar fracture with nerve injury undergoing common pedicle screw placement under direct vision combined with dome shaped decompression via small incision between November 2011 and November 2015 (combined surgery group), and another 32 patients undergoing traditional open pedicle screw fixation surgery (traditional surgery group). There was no significant difference in gender, age, cause of injury, time of injury-to-surgery, injury segments and Frankel classification of neurological function between two groups (P>0.05). The length of soft tissue dissection, the operative time, the blood loss during surgery, the postoperative drainage, the visual analogue scale (VAS) of incision after surgery, and recovery of neurological function after surgery were evaluated. Results All cases were followed up 9 to 12 months (mean, 10.5 months) in combined surgery group, and 8 to 12 months (mean, 9.8 months) in traditional surgery group. The length of soft tissue dissection, the operative time, the blood loss during surgery, the postoperative drainage, and the postoperative VAS score in the combined surgery group were significantly better than those in the traditional surgery group (P<0.05). Dural rupture during surgery and pedicle screw pulling-out at 6 months after surgery occurred in 2 cases and 1 case of the combined surgery group; dural rupture during surgery occurred in 1 case of the traditional surgery group. The X-ray films showed good decompression, and fracture healing; A certain degree of neurological function recovery was achieved in two groups. Conclusion Common pedicle screw placement under direct vision combined with dome shaped decompression via small incision can significantly reduce iatrogenic trauma and provide good nerve decompression. Therefore, it is a safe, effective, and minimally invasive treatment method for double segment thoracolumbar fracture with neurological injury.

          Release date:2017-06-15 10:04 Export PDF Favorites Scan
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