ObjectiveTo summarize the recent years' researches of the role of microRNAs (miRNAs) in gastric cancer.
MethodsDomestic and international publications related to miRNAs biological functions and its role in gastric cancer in recent years were collected and reviewed.
ResultsMiRNAs are binded to some target mRNAs which are related to gastric cancer, then result in these mRNAs silence and target-genes abnormal expression. Conciusions MiRNAs play a crucial role in tumorigenesis and development of gastric cancer, and act as a oncogene or anti-oncogene in gastric cancer.
Objective To review the latest research progress on keratinocyte growth factor (KGF), to thoroughlyunderstand its basic characteristics and appl ication methods and to lay a sol id foundation for the research and development of new KGF medicines and improving the qual ity of skin substitutes. Methods Domestical and international l iteratures on KGFin recent years were extensively reviewed and analyzed. Results KGF was secreted by mesenchymal cells and its receptors were distributed in epithel ium to promote the prol iferation, migration and differentiation of epithel ial cell specifically, which closely related to the organ development, wound heal ing, tumorigenesis and immune reconstruction. Conclusion KGF can be used to improve wound heal ing and the performance of skin substitutes. However, the structure of KGF needs to be changed to el iminate its side effects and purify its promoting effect on epithel ial cell growth.
