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Danhong Injection and Vinpocetine Improve the Intelligence of Vascular Dementia Patients in Clinical

摘要:目的:探索丹紅注射液聯合長春西汀對老年血管性癡呆患者智能狀況的改善效果。方法:將116例符合血管性癡呆標準的患者分為對照組和治療組。對照組用血塞通0.4 g,治療組用丹紅注射液20 mL和長春西汀10 mg,10 d為1個療程,6個月共6個療程,其后分別采用中文版簡易智能狀態檢查(MMSE)量表進行積分,用中國修訂韋氏成人量表(WAISRC)進行智力測驗比較。結果:根據WAISRC測驗結果,兩組1年后知識、領悟、算術、相似、數字廣度、詞匯、數字符號、填圖、圖片排列等項目比較,治療組積分明顯高于對照組t=1.98～5.25,Plt;0.05或001),治療組治療前后上述項目自身對照積分亦有顯著提高(t=1.68～4.25,Plt;0.05或0.01)。結論:丹紅注射液聯合長春西汀能有效抑制神經細胞的凋亡,改善腦部供血,減少腦功能的受累.治療血管性癡呆,對老年群體的康復有積極的治療作用。Abstract: Objective:To investigate the curative effect of DanHong injection and Vinpocetine injection in improving intelligence of vascular dementia (VD) patients. Methods: One hundred and sixteen patients with VD were randomly assigned to treat with Danhong at a daily dose of 20 mL and Vinpocetine at a daily dose of 10 mg (treatment group) and Xuesaitong at a daily dose of 0.4 g alone (control group) for 10 day as a course. The duration was six months for 6 courses. To score using the Mini. Mental state examination (MMSE) of Chinese version and WAISRC were conducted after 1 year. Results: At the end of one year, according to WAISRC examination. The scores of knowledge, comprehension, arithmetic, acquaintance, digit span,vocabulary figure,fill the diagram and toy bricks were significantly higher than those of the control group (t=1.985.25 Plt;0.05).Before and after treatment, there was a significant difference in the treatment group (t=1.684.25 Plt;0.05 or 0.01).Conclusion: DanHong injection and Vinpocetine injection are effective to inhibit the apoptosis of nerve cells. and decrease the tiredness of brain function. It has a certain effect in treatment of vascular dementia and plays a good role in the rehabilitation of oldage community