Objective To evaluate the efficacy of transcatheter arterial chemoembolization (TACE) combined with radiofrequency ablation (RFA) in treating primary hepatocellular carcinoma (HCC). Methods From March 2004 to March 2006, 137 patients with primary HCC underwent TACE alone (n=87) and TACE+RFA (n=50), respectively, after the interventional treatment, all patients periodically received CT reexaminations and alpha fetoprotein (AFP) measurement. The therapeutic efficacy, AFP level and survival rate between two groups were compared with each other. Results In TACE group the effective rate (CR+PR) was 34.5%, AFP decreasing amplitude was 54.2%, and 2 years survival rate was 43.7%. While in TACE+RFA group, the effective rate (CR+PR) was 70.0%, AFP decreasing amplitude was 78.0%, and 2 years survival rate was 62.0%, there were significant differences between two groups (P＜0.05). Conclusion Combined application of TACE and RFA is significantly superior to TACE alone in treatment of primary HCC.
目的:探討氟西汀聯合心理干預治療心血管疾病患者伴焦慮抑郁癥狀的臨床療效。方法:選擇伴有抑郁、焦慮情緒障礙的85例冠心病患者(心功能Ⅱ、Ⅲ級),并將其隨機分成研究組和對照組。觀察6w,對照組患者僅給予常規的治療,研究組患者在常規治療基礎上給予氟西汀聯合心理干預治療。觀察治療前后兩組患者采用漢密頓焦慮量表( Hamilton Anxiety Scale,HAMA) 評定焦慮癥狀,漢密頓抑郁量表( Hamilton Depression Scale,HAMD) 評定抑郁癥狀;并對治療后心功能分級(NYHA)恢復到Ⅰ級的例數及左室射血分數進行分析評價。結果:治療6 周 后,研究組均較對照組的漢密頓焦慮量表及漢密頓抑郁量表評分下降顯著( P lt;0.01),研究組抗焦慮顯效率為87.16%、抗抑郁顯效率為82.26%,對照組分別為43.75%、45.36%,研究組均顯著高于對照組( P lt;0.01);研究組患者的左室射血分數顯著高于對照組 ( P lt;0.05),心功能分級(NYHA)恢復到Ⅰ級的例數顯著高于對照組 ( P lt;0.05)。結論:氟西汀聯合心理干預治療不僅能改善心血管疾病伴焦慮抑郁患者的焦慮、抑郁情緒障礙,還能改善患者的心功能,療效顯著優于單用心血管藥物治療。
Objective To investigate the antibiotic resistance and their genetic homology of stenotrophomonas maltophilia isolated from January 2005 to February 2006 at intensive care unit（ICU） of 6 hospitals in Bejing area.Methods The minimal inhibitory concentration（MIC） of 12 antibiotics against 82 strenotrophomonas maltophilia was determined by broth dilution method.PFGE was used to analyze the homology of 82 stenotrophomonas maltophilia.Results The drug sensitivity tests in vitro showed these strains were resistance to commonly-used antibiotics.Antibiotics with sensitive rate over 50% included Doxycycline, gatifloxacin,cefoperazone-sulbactam,levofloxacin,Compound sulfamethoxazole,Ceftazidime and ticarcillin- clavulanate. 7-18 DNA bands of different size were present in the gel and different homology was shown among the 82 strains.Four couples with homology over 85% were isolated from the same ICU.Three strain were same clones in PLA General Hospitals first hospital.2 couples from the different wards had homology of 80.6% and 79.6% of，respictively.Others strains had either poor or no homology.Conclusions No clonal outbreak is certified at ICU of 6 hospitals in Beijing area. There are only vertical dissemination of single clone in 6 ICU wards.PFGE is an effective approach for drug resistance test and epidemic analysis.
