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        west china medical publishers
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        find Author "WANG Juanhong" 2 results
        • Detection of ER, PR and P53 in Endometrial Carcinoma and Their Clinical Significance

          目的 探討子宮內膜癌中雌激素受體(ER)、孕激素受體(PR)和p53的表達及其臨床意義。 方法 1994年1月-2009年11月,應用免疫組織化學Envision法檢測52例子宮內膜癌中ER、PR和p53的表達情況并進行統計學分析。 結果 ER、PR和p53陽性表達率分別為51.9%、50.0%和46.2%。ER、PR的陽性表達率與癌組織的細胞分化程度有關(Plt;0.05)。隨著組織學分級的增高,ER、PR陽性表達率逐漸降低(在Ⅰ、Ⅱ和Ⅲ級子宮內膜癌中,ER陽性表達率分別為64.0%、56.3%和18.2%, PR陽性表達率分別為72.0%、37.5%和18.2%)。隨著組織學分級的增高及淋巴結轉移,p53的陽性表達率逐漸增高(Plt;0.05),p53表達與ER、PR表達有關(Plt;0.05)。 結論 ER、PR和p53的表達與子宮內膜癌組織學分級和生物學行為密切相關,其測定對評估子宮內膜癌預后,指導臨床治療具有重要意義。

          Release date:2016-09-08 09:47 Export PDF Favorites Scan
        • Evidence-Based Research on Rural Primary Physicians Training Modes in Gansu Province

          Objective To get known the existing problems in rural primary physicians training in Gansu province, so as to explore an appropriate training mode for Gansu province. Methods This study conducted a comprehensive analysis by combining literature analysis, on-site survey and interview. Such databases as CNKI, VIP and CBM were searched to include literature published before November 2011, and the references of the included literature were also retrieved. The qualitative analysis was performed after assessing the methodological quality of the included literature according to self-designed criteria. Additionally, the rural primary hospitals in Gansu province were classified according to their geographical position and economic development level, total 10 township hospitals were randomly selected by cluster sampling, and the following stuffs participated various trainings in past 3 years were on-site-investigated: clinical doctors, nurses, medical technicians, and medical administrators, in aspects of training time, place, contents, modes, and effects. Results The existing problems in primary physicians training modes in Gansu were as follows: uneven training levels, lack of targeted contents, neglect of skill training and process management, and absence of quality assessment of training processes and effects. Conclusion The training modes require that: a) specific plans and schemes; b) unified organization to integrate educational resources effectively; c) reasonable arrangement of implementation process, and d) innovation of training methods and contents to fully play the role of general hospitals and universities; and well control and feedback to promote the integration and perfection of training modes.

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