ObjectiveTo summarize the advances of precl inical research in xenogeneic (porcine) cell transplantation in recent years.
MethodsThe literature about the precl inical research in xenogeneic (porcine) cell transplantation was analyzed and summarized.
ResultsWith the application of new immunosuppressive agents and the generation of transgenic pigs, great progress has been achieved in xenogeneic transplantation of pig-derived nerve cells, islet cells, liver cells, and various types of stem cells. The survival time of xenogeneic cell (porcine) significantly prolonged, but there is still a long way to go before cl inical application.
ConclusionThe source of xenogeneic (porcine) cells is abundant and the experiments are reproducible. However, how to effectively prevent rejection and prolong the survival time in the host, and avoid the spread of virus between species are still need to be solved in the future research.
A critical shortage of donor organs raises a question of needs for alternative organ sources for regenerative medicine. Over the last decade, three-dimensional (3D) culture has become a new approach for organ regeneration. The 3D culture takes significant advantages of cells spatial relationships between multiple cellular types and surrounding matrices of dynamic cellular interactions, which plays a key role in structural self-formation of complex organ buds. Here we present major classic cases of 3D culture organ regeneration to show how it works, and then we try to find the way of future organ regeneration.
