Objective To find out Shanxi genuine drug food homologous substances for type 2 diabetes complicated with hypertension, and to explore its mechanism. Methods The targets of type 2 diabetes and hypertension were obtained from TTD, Drugbank and GeneCards databases, and the intersection targets of the two were obtained. After UniProt database transformation, the protein-protein interaction network was established on the String platform. Degree values were used to screen core targets, followed by enrichment analysis. TCMSP database was used to carry out reverse screening of traditional Chinese medicine ingredients and corresponding traditional Chinese medicine. The key target-active ingredient-traditional Chinese medicine network was constructed. Chinese medicine with a certainty value≥3 was overlapped with drug food homology directory, Shanxi genuine drug directory, and drug use law directory of type 2 diabetes complicated with hypertension to obtain the best drug food homologous substances. Results After screening, 715 intersecting targets were identified, 23 key targets and 818 traditional Chinese medicine ingredients were determined, and 24 active ingredients with retention values≥4 were identified as core active ingredients. A total of 302 traditional Chinese medicines were reverse screened. There were 14 kinds of drug food homologous substances, and Radix Astragali was finally selected as the best drug food homologous substance for type 2 diabetes complicated with hypertension. Conclusion Radix Astragali may be used to prevent and treat type 2 diabetes complicated with hypertension, but the related research only involves theoretical aspects, which needs to be verified by trials in the future.
