ObjectiveThis study aims to summarize the risk factors and therapeutic strategies for early recurrence after hepatocellular carcinoma (HCC) resection, so as to provide a reference for the prediction of postoperative early recurrence and the treatment of recurrent HCC. MethodsThe article gives a summary of the risk factors for early recurrence and treatment after hepatectomy for HCC by searching for relevant studies at home and abroad in recent years. ResultsHCC is a common and highly fatal malignant tumor worldwide. Surgical resection remains the preferred treatment method, but the early recurrence rate (recurrence within 2 years after surgery) is as high as 40%-50%, which seriously affects the prognosis of patients. The risk factors for early recurrence of HCC include patient factors (gender, marital status, liver status, inflammatory indicators, nutritional status, etc.), tumor factors (tumor markers, diameter, number, degree of differentiation, margin and capsule, microvascular invasion, satellite nodules, etc.) and surgical factors (whether anatomical resection or not, resection margin, perioperative blood transfusion, etc.); treatment methods include reoperation (laparoscopic, open), salvage liver transplantation, radiofrequency ablation, interventional therapy (transarterial chemoembolization, transhepatic arterial infusion chemotherapy, transarterial radioembolization) and systemic therapy (targeted immunotherapy, antiviral therapy and traditional Chinese medicine therapy). ConclusionEarly recurrence after HCC hepatectomy severely compromises the long-term survival of patients. Going forward, efforts should be devoted to developing accurate prediction models for postoperative early recurrence, further clarifying the optimal therapeutic regimens for recurrent HCC under different clinical scenarios, and providing evidence for individualized treatment to improve the overall prognosis of patients.
