Objective To analyze the current status and development trends of the traditional Chinese medicine (TCM)-related projects under the national undergraduate innovation and entrepreneurship training program (NUIETP), aiming to provide evidence for optimizing policies and practices in TCM innovation and entrepreneurship education. Methods Quantitative analysis and visualization were conducted on project data of TCM-related NUIETP initiatives published on the official platform from 2019 to 2024. Results A total of 245 091 projects data were included, including 4 398 projects related to TCM. From 2019 to 2024, the number of TCM-related NUIETP showed an overall upward trend, with innovation training projects accounting for the majority. Projects in Traditional Chinese Medicine and Chinese Materia Medica disciplines dominated. The number of participating institutions continued to grow, with TCM institutions performing outstandingly. The most common team configuration consisted of five project members and one supervising instructor, with the number varying depending on the project type and discipline. Project topics were primarily focused on TCM, with clear project type positioning and distinct disciplinary characteristics. Conclusions The TCM-related NUIETP demonstrate a trend of expanding scale and innovation-driven development, reflecting the synergistic effects of policy support and institutional resources. However, challenges persist, such as weak entrepreneurial translation and insufficient interdisciplinary collaboration. Recommendations include refining management systems, fostering innovation-to-entrepreneurship pathways, strengthening multidisciplinary integration, and optimizing team structures to advance high-quality TCM innovation and entrepreneurship.
Objective To investigate the effect of chaiqin chengqi decoction (CQCQD) on serum lipid metabolism in experimental acute pancreatitis. Methods A total of 27 C57BL/6 mice were randomly divided into three groups (n=9 for each group). The mice in the acute pancreatitis model group (AP group) and the acute pancreatitis model + CQCQD treatment group (APQ group) received seven intraperitoneal injections of cerulein (50 μg/kg) at hourly intervals, while the mice in the control group (CON group) received phosphate-buffered saline injections at the same regimen of cerulein. Oral gavage of CQCQD (5.5 g/kg) or same volume of distilled water was commenced 1 h after the first cerulein injection for three times at intervals of 4 h for the APQ group and AP group, respectively. Animals were sacrificed 12 h after the first cerulein / phosphate-buffered saline injection for collecting serum and tissue samples. The levels of serum lipase and amylase, pancreatic histopathology assessment, as well as pancreatic myeloperoxidase activity, were used to assess the severity of acute pancreatitis and the efficacy of CQCQD. Additionally, serum lipid metabolites were analyzed in all groups. Results In comparison to the CON group, the mice in the AP group exhibited significant edema, inflammatory cell infiltration, necrosis of pancreatic tissues, as well as elevated levels of serum amylase, lipase, and pancreatic myeloperoxidase activity (P<0.05); in comparison to the AP group, inflammatory cell infiltration and necrosis of pancreatic tissue, as well as elevated level of serum amylase significantly reduced in the APQ group (P<0.05). A total of 319 lipid molecules were identified in serum, and 13 lipid metabolites were significantly increased in the AP group and successfully decreased in the APQ group, of which 9 were lyso-phosphatidylethanolamine (LPE) molecules involved in the glycerol phospholipid metabolic pathway. Further statistical analysis revealed that six of these LPE molecules could serve as potential biomarkers. Conclusions CQCQD ameliorated pancreatic injury and serum lipid metabolism disorder of acute pancreatitis model induced by cerulein and significantly improved the abnormal increase of serum LPE level. However, the role of LPE in acute pancreatitis and the underlying mechanisms of CQCQD on LPE metabolic pathways still need further study.
