【Abstract】ObjectiveTo investigate the relationship between tumor suppressor gene DPC4 and the development and prognosis of pancreatic carcinoma. MethodsRelevant literatures of recent years were reviewed. ResultsDPC4 was located on chromosome 18. Its product was Smad 4 protein. Smad 4 protein was the central component of the transforming growth factor-beta signaling pathway, and all the biological effect was the results of interaction of Smad 4 and different Smads. The gene was deleted or inactive in about 50% of pancreatic carcinomas. The deletion of DPC4 had a great relation to the development and prognosis of pancreatic carcinoma. ConclusionThe alteration of tumor suppressor gene DPC4 is connected with the development and prognosis of pancreatic carcinoma. However, this research should be further studied.
目的 分析朱砂蓮中毒導致急性腎功能衰竭臨床表現、腎臟病理學及相關文獻復習。 方法 2007年3月－9月收治朱砂蓮中毒急性腎功能衰竭2例，分析臨床表現及腎臟病理損害。 結果 朱砂蓮急性中毒易致急性腎功能衰竭，危及生命；其主要損害腎小管間質，表現為急性腎小管重度損傷，無炎性細胞浸潤，而腎小球幾乎無病變。 結論 朱砂蓮為我國常使用中藥，主要成分為馬兜鈴酸，易致馬兜鈴酸腎病，須提高對該病認識，規范使用中草藥，避免藥物性所致腎損害。Objective To analyze the clinical and pathological manifestations of kidney in patients with ciliatenerve knotweed root-induced acute renal failure. Methods Two patients who were admitted into our hospital for acute renal failure caused by over-dose ciliatenerve knotweed root from March to September in 2007 were included in this study. We analyzed the clinical and pathological manifestations of their kidneys. Results Over-dose ciliatenerve knotweed root could induce acute renal failure, even threaten life. The pathology of kidney is characterized by severe tubular injury,rather than glomerulus damage, without cell infiltration. Conclusions Ciliatenerve knotweed root is one of the frequently-used traditional Chinese medicines in our country, which can easily result in aristolochinc acid nephropathy. We should recognize the importance of this disease and avoid using nephrotoxic drugs.
