ObjectiveTo understand the research progress of triggering receptor expressed on myeloid cells-1 (TREM-1) in abdominal infection and sepsis. MethodsThe relevant literatures at home and abroad in recent years regarding the research on the role of TREM-1 in abdominal infection and sepsis were retrieved and reviewed. ResultsRecent studies have focused on the key role of TREM-1 in abdominal infection and sepsis. TREM-1 is a pattern recognition receptor, which rapidly upregulated under inflammatory stimulation, forming a positive feedback loop that significantly amplifies the immune response. Its activation can trigger the cascaded release of a large number of proinflammatory factors and chemokines, exacerbating the inflammatory storm; at the same time, excessive activation of the pathway is regarded as the core driving mechanism for the progression of sepsis and even septic shock. ConclusionsThe TREM-1 mediated amplification effect of inflammatory cascades has been identified as a key link in immune imbalance in infectious diseases such as sepsis and abdominal infection. Further clarification of the expression dynamics of TREM-1 under different infectious conditions and the regulatory mechanisms of its signaling pathways is expected to provide new biomarkers for the clinical diagnosis and prognostic evaluation of infectious diseases, as well as theoretical basis for targeted intervention strategies and new drug development, thereby promoting the establishment and optimization of precise diagnosis and treatment regimens.
