Single-case experimental design (SCED), which emphasizes within-subject causal inference, offers distinct advantages for evaluating individualized interventions and has been increasingly applied in behavioural intervention research in recent years. However, existing SCED studies still exhibit considerable variability in terminology, design implementation, and reporting completeness, which undermines research transparency, reproducibility, and the value of evidence synthesis. To improve the reporting quality of behavioural intervention-related SCED studies, the SCRIBE working group published the single-case reporting guideline in behavioural interventions (SCRIBE 2016), a 26-item reporting checklist, in 2016. This article reviews the development background and core contents of SCRIBE 2016, provides a systematic interpretation of its reporting items, and uses illustrative examples to clarify the meanings of relevant terms and key reporting requirements. It is intended to serve as a practical reference for Chinese researchers in understanding and applying SCRIBE 2016 and in improving the reporting quality of SCED studies in behavioural intervention research.
ObjectiveTo investigate the radiological and clinicopathological factors affecting the postoperative recurrence of early lung adenocarcinoma with micropapillary/solid structure.MethodsA total of 198 patients undergoing surgical resection for early stage lung adenocarcinoma in the First Affiliated Hospital of Nanjing Medical University from January 2016 to August 2019 were enrolled, including 100 males and 98 females, aged 28-82 (53.5±9.5) years. All patients were allocated to a recurrence group (n=21) and a non-recurrence group (n=177) according to postoperative recurrence status. Correlations of imaging and clinical features and clinical outcomes were analyzed to determine prognostic significance.ResultsThe mean follow-up time was 27.0±11.2 months. There was no statistical difference in the imaging features of tumor maximum diameter in mediastinal window (P=0.014), C/T ratio (P=0.001), bronchial positive sign (P=0.015), pathological features of vascular invasion (P=0.024) and postoperative chemotherapy (P<0.001) between the two groups. In multivariate analysis, vascular invasion was the only independent prognostic factor (OR=0.146, P=0.047).ConclusionVascular invasion is an independent risk factor for postoperative recurrence of early-stage lung adenocarcinoma with micropapillary/solid structure.
