ObjectiveTo summarize the tissue engineering techniques for cartilage repair on the combination fields of the three elements of tissue engineering:cells, scaffolds and signals.
MethodsThe literature on cell-scaffold-based cartilage repair techniques, cell-free scaffolds, and scaffold-free approaches was reviewed and summarized.
ResultsThe cell-scaffold-based cartilage repair techniques such as matrix-induced autologous chondrocyte implantation (chondrocytes are seeded on the scaffold) are able to enhance the survival of the cells; cell-free scaffolds can promote cell recruitment with chemoatractants; and scaffold-free approaches have better hyaline-like properties and can avoid the toxic effect of scaffold degradation products.
ConclusionCombination fields of the three elements of tissue engineering provide a more biomimetic environment for cartilage repair and have broad prospects.
Objective
To summarize the research progress of rehabilitation after autologous chondrocyte implantation (ACI).
Methods
The literature related to basic science and clinical practice about rehabilitation after ACI in recent years was searched, selected, and analyzed.
Results
Based on the included literature, the progress of the graft maturation consists of proliferation phase (0-6 weeks), transition phase (6-12 weeks), remodeling phase (12-26 weeks), and maturation phase (26 weeks-2 years). To achieve early protection, stimulate the maturation, and promote the graft-bone integrity, rehabilitation protocol ought to be based on the biomechanical properties at different phases. Weight-bearing program, range of motion (ROM), and options or facilities of exercise are importance when considering a rehabilitation program.
Conclusion
It has been proved that the patients need a program with an increasingly progressive weight-bearing and ROM in principles of rehabilitation after ACI. Specific facilities can be taken at a certain phase. Evidences extracted in the present work are rather low and the high-quality and controlled trials still need to improve the rehabilitation protocol.
