ObjectiveTo explore the correlation between lipid profile and molecular typing of invasive breast cancer.MethodsThree hundreds and seventy-five patients with primary invasive breast cancer diagnosed from Breast Surgery, Affiliated Hospital of Southwest Medical University from January 2018 to June 2019. The total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), Low-density lipoprotein cholesterol (LDL-C), apolipoprotein A (ApoA), and apolipoprotein B (ApoB) concentrations were detected. Molecular classification based on the results of postoperative immunohistochemistry of breast cancer patients, compared the measured values of each subtype.ResultsThere were no significant difference in serum TG, HDL-C and ApoA among the four subtypes (P>0.05). Differences serum levels of TC, LDL-C, and ApoB among breast cancer patients of various subtypes were statistically significant (P<0.05). Serum TC concentration in the HER2 overexpression type [(5.08±1.00) mmol/L] and the triple negative type [(5.12±0.91) mmol/L] were significantly higher than the Luminal A type [(4.68±1.01) mmol/L] and the Luminal B type [(4.79± 0.93) mmol/L], P<0.05. Serum LDL-C concentration in the triple negative type [(3.14±0.88) mmol/L] was significantly higher than the LuminalA type [(2.77±0.84) mmol/L] and the LuminalB type [(2.87±0.81) mmol/L], P<0.05. Serum ApoB concentration in the Luminal B type [(0.94±0.23) g/L] was significantly lower than the triple negative type [(1.03±0.23) g/L].ConclusionThere are differences in serum TC, LDL-C and apoB concentrations among different subtypes of breast cancer, but TG, HDL-C and ApoA are not related to molecular typing of breast cancer.
Objective To investigate the long-term dynamic changes of liver function and glucose-lipid metabolism in human immunodeficiency virus (HIV)-infected patients with metabolic dysfunction-associated fatty liver disease (MAFLD) after antiretroviral therapy (ART). Methods HIV-infected patients who visited Public Health Clinical Center of Chengdu between October 1st, 2012 and June 30th, 2013 were recruited and divided into two groups according to whether they had MAFLD or not. All of them were treated with the first-line regimen of tenofovir + lamivudine + efavirenz for 156 weeks, and the anthropometric indices, liver function, and levels of glucose, lipids and uric acid were measured at baseline and at each follow-up time point. In addition, the long-term dynamic characteristics of liver function and glucose and lipid metabolism parameters of the two groups were compared during the 156 weeks of ART treatment. Results A total of 61 male HIV-infected patients were enrolled. The prevalence of MAFLD in them was 31.1% (19/61) at baseline and increased by 4.9 percentage points per year after ART. Before the start of follow-up (week 0), the levels of alanine aminotransferase (ALT) [(46.23±27.09) vs. (28.00±17.43) U/L, P=0.002] and γ-glutamyl transpeptidase (GGT) [(41.46±9.89) vs. (24.02±10.72) U/L, P<0.001] were higher in the MAFLD group than those in the non-MAFLD group, while the between-group differences in the levels of aspartate aminotransferase (AST) [(33.33±15.61) vs. (28.98±12.43) U/L, P=0.248] and alkaline phosphatase [(85.30±21.27) vs. (83.41±24.47) U/L, P=0.773] were not statistically significant. During the 156-week follow-up period, the 4 items of liver function gradually increased in the MAFLD group, especially from week 120 onwards, 3 of which (ALT, AST and GGT) were significantly higher than those in the non-MAFLD group (P<0.05). In addition, the levels of fasting blood glucose, triglyceride, total cholesterol, and low-density lipoprotein were also significantly higher in the MAFLD group than those in the non-MAFLD group at some time points during the 156-week follow-up period (P<0.05). Conclusions Compared with HIV-infected patients without MAFLD, HIV-infected patients with MAFLD are more likely to develop impaired liver function and disorders of glucose and lipid metabolism during long-term tenofovir + lamivudine + efavirenz regimen ART treatment. Therefore, close clinical monitoring of liver function and glucose and lipid metabolism related parameters is required for such patients.
Objective To investigate the correlation between cervical Modic change (MC) and blood lipid and glucose levels. Methods Patients hospitalized with neck and shoulder pain in the Affiliated Hospital of North Sichuan Medical College between January 2015 and January 2021 were selected and divided into MC group and non-MC group according to whether the signal changes of cervical vertebral endplate occurred on MRI. The general data (age, gender, smoking history, drinking history), blood lipid indicators (high-density lipoprotein, low-density lipoprotein, lipoprotein a, total cholesterol, triglyceride) and blood glucose indicators (glycosylated hemoglobin, fasting blood glucose) were compared between the two groups. Multivariate logistic regression analysis was used to explore the correlation between MC and various indicators. Results A total of 160 patients were included, including 48 patients in MC group and 112 patients in non-MC group. The age [(61.46±12.10) vs. (56.22±10.65) years], total cholesterol [(5.06±1.17) vs. (4.44±1.31) mmol/L], triglyceride [(1.61±0.64) vs. (1.38±0.58) mmol/L], glycosylated hemoglobin (6.78%±1.27% vs. 5.79%±0.85%), and fasting blood glucose [(7.84±1.51) vs. (6.93±1.47) mmol/L] of the patients in MC group were significantly higher than those in non-MC group (P<0.05). There was no significant difference in gender, smoking ratio, drinking ratio, high-density lipoprotein, low-density lipoprotein or lipoprotein a between the two groups (P>0.05). Logistic regression analysisshowed that age [odds ratio (OR)=1.064, 95% confidence interval (CI) (1.022, 1.109), P=0.003], total cholesterol [OR=1.788, 95%CI (1.187, 2.694), P=0.005], triglyceride [OR=2.624, 95%CI (1.257, 5.479), P=0.010] and glycosylated hemoglobin [OR=4.942, 95%CI (2.446, 9.987), P<0.001] were risk factors of cervical MC. Conclusions Age, total cholesterol, triglyceride and glycosylated hemoglobin are risk factors of cervical MC. Elderly patients with hyperlipidemia and hyperglycemia should be alert to the occurrence of cervical MC. Controlling the levels of blood lipid and glucose may reduce the risk of cervical MC.
Objective To analyze the distribution differences of lipid-related metabolic indicators between interstitial lung abnormality (ILA) and non-ILA, as well as between ILA subtypes, and to evaluate their associations with ILA and subpleural fibrotic ILA subtype which carries a high risk of progression. Methods A cross-sectional study was conducted based on a health screening cohort from West China Hospital of Sichuan University and four physical examination centers between January 2013 and January 2023. Propensity score matching was employed to balance baseline characteristics between ILA and non-ILA populations. Multivariate logistic regression, restricted cubic spline, and stratified interaction analyses were performed to assess the associations of triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), TG/HDL-C ratio, and the triglyceride-glucose (TyG) index with ILA and subpleural fibrotic ILA. Results Compared with the non-ILA group (n=6690), the ILA group (n=6690) exhibited higher levels of TG, LDL-C, TG/HDL-C ratio, and TyG index (P<0.05), and lower levels of TC and HDL-C (P<0.05). Compared with the non-fibrotic ILA group (n=5603), the fibrotic ILA group (n=1087) had lower levels of TG, TC, LDL-C, TG/HDL-C ratio, and TyG index (P<0.05). Elevated levels of TG [odds ratio (OR)=1.050, 95% confidence interval (CI) (1.023, 1.078), P<0.001], LDL-C [OR=1.067, 95%CI (1.021, 1.115), P=0.004], TG/HDL-C [OR=1.047, 95%CI (1.025, 1.069), P<0.001], and TyG [OR=1.106, 95%CI (1.039, 1.176), P=0.002] were independently associated with an increased odds of ILA, whereas higher TC [OR=0.954, 95%CI (0.919, 0.990), P=0.015] and HDL-C [OR=0.491, 95%CI (0.438, 0.549), P<0.001] were independent related to lower odds of ILA. Elevated HDL-C [OR=0.731, 95%CI (0.584, 0.909), P=0.005] showed an independent linear correlation with reduced odds of fibrotic ILA. Stratified analysis indicated that age (P-interaction=0.002) exerted a modulatory effect on HDL-C and fibrotic ILA. A risk prediction model of fibrotic ILA constructed using 8 indicators including age, HDL-C, and albumin yielded an area under the curve of 0.659 [95%CI (0.642, 0.677)]. Conclusions blood lipid profile and metabolic index exhibited heterogeneous distribution patterns across different subtypes of ILA. While elevated TG, LDL-C, TG/HDL-C, and TyG index, along with decreased TC and HDL-C, are independently associated with an increased risk of ILA, only HDL-C maintained a linear independent correlation with a reduced risk of fibrotic ILA. The predictive model integrating HDL-C, age and other indicators demonstrated moderate value for identifying fibrotic ILA. These findings highlighted the complex interplay between lipid metabolism and ILA and provide hematological evidence for the early identification of high-risk ILA subtypes.
