Despite of the progress in the treatment of severe acute pancreatitis (SAP), there are still factors that hinder the improvement of the efficacy of treatment: there is a lack of an accurate and easy-to-use system for early severity prediction; the multidisciplinary collaboration mechanism needs to be further optimized; there is no clinical efficacy evaluation system for traditional Chinese medicine (TCM); the therapeutic targets of TCM are unclear; the effector substances are unknown; and the research and development of new medicines is still difficult. In order to further reduce the mortality of SAP and realize the goal of improving the efficacy, we should strengthen the integration of Chinese and Western medicine, multidisciplinary collaboration, and improve the treatment levels; as well as carry out basic and clinical research oriented to clinical value. We will also promote the innovative development of combined Chinese and Western medicine in the treatment of SAP by elucidating the mechanism, validating the efficacy and commercializing the achievements. In view of SAP, a major and difficult disease, we should insist on the principle of integrity and innovation, the synergy of Chinese and Western medicines and the complementarity of advantages, and promote the innovation and development of combined Chinese and Western medicines in the treatment of SAP, so as to further reduce the morbidity and mortality and to alleviate the burden of the disease.
As an important method for minimally invasive treatment of pulmonary nodules, cryoablation and thermal ablation have the advantages of short hospital stay and low medical cost, with a higher cost-effectiveness ratio. Cryoablation, with its "visual ice ball effect" and lower "heat sink effect", shows unique advantages in the treatment of nodules near large blood vessels, airways and other special areas. Among thermal ablation techniques, microwave ablation, with its high heating efficiency and less influence from blood flow, has become the preferred option for nodules larger than 3 cm or those adjacent to blood vessels; radiofrequency ablation has a higher local control rate in small-volume (less than 1 cm) nodules and subsolid nodules. Through literature review, it is found that there are few studies comparing cryoablation and thermal ablation and systematically and comprehensively elaborating on the application status, safety and management of complications of cryoablation and thermal ablation. Therefore, this article will systematically review the basic principles of cryoablation and thermal ablation, the current clinical application status in pulmonary nodules, the comparison between cryoablation and thermal ablation, and the safety and management of complications.
