ObjectiveTo investigate the correlation between graft maturity and knee function after anterior cruciate ligament (ACL) reconstruction.MethodsA total of 50 patients who underwent ACL reconstruction with autologous tendons between August 2016 and August 2018 were included in the study. There were 28 males and 22 females, with an average age of 31.0 years (range, 18-50 years). At 6 months and 2 years after operation, the signal to noise quotient (SNQ) values of tibial and femoral ends of graft were measured by MRI, and the mean value was taken as the SNQ value of graft. The function of knee joint was evaluated by Tegner, Lysholm, and International Knee Documentation Committee (IKDC) scores. The differences in SNQ values between tibial and femoral ends were analyzed at 6 months and 2 years after operation. The correlation between SNQ value at 6 months after operation and knee function score at 2 years after operation was analyzed. According to SNQ value at 6 months after operation, the patients were divided into group A (SNQ value≥12) and group B (SNQ value<12) and the correlation between SNQ value and knee function score was further analyzed.ResultsAll incisions healed primarily without infection or injury of blood vessels and nerves. All patients were followed up 24-28 months (mean, 26.6 months). The IKDC, Lysholm, and Tegner scores at 6 months and 2 years after operation were significantly higher than those before operation (P<0.05), and all scores at 2 years after operation were also significantly higher than those at 6 months (P<0.05). The SNQ values at 6 months and 2 years after operation were 12.517±6.272 and 10.900±6.012, respectively, and the difference was significant (t=1.838, P=0.007). The SNQ values of graft at 6 months after operation were significantly different from those at 2 years after operation (P<0.05), and the SNQ values of tibial and femoral ends of graft at the same time point were significantly different (P<0.05). The SNQ value of 50 patients at 6 months after operation was negatively correlated with Lysholm, IKDC, and Tegner scores at 2 years after operation (r=–0.965, P=0.000; r=–0.896, P=0.000; r=–0.475, P=0.003). The patients were divided into groups A and B according to the SNQ value, each with 25 cases; the SNQ values of the two groups at 6 months after operation were negatively correlated with Lysholm, IKDC, and Tegner scores at 2 years after operation (P<0.05).ConclusionAfter ACL reconstruction, the knee function scores and graft maturity of patients gradually improved. The lower the SNQ value in the early stage, the higher the knee function score in the later stage. The SNQ value of MRI in the early stage after ACL reconstruction can predict the knee function in the later stage.
Objective To investigate the relationship between the mean corpuscular volume/red blood cell distribution width ratio (MRR) and stroke, providing a new perspective for the risk assessment and early prevention of stroke. Methods The study was based on the complex sampling design of data from the National Health and Nutrition Examination Survey from 1999 to 2018 and included 17434 eligible participants aged 18 years and older. MRR was calculated based on the mean corpuscular volume and red blood cell distribution width, and stroke patients were determined based on the health status questionnaire. According to the quartiles of MRR, the included participants were divided into Q1, Q2, Q3, and Q4 groups. Multivariate logistic regression analysis was used to explore the association between MRR and the incidence of stroke. Official sampling weights, stratification variables, and primary sampling units were incorporated throughout this study for weighting adjustment, and weighted statistical methods suitable for complex samples were adopted for data analysis and intergroup comparisons. Results Among all the participants, there were 625 stroke patients, with a weighted stroke prevalence of 2.7%. The MRR of the overall population were (6.58±0.78) fL/%. The results of the multivariate logistic regression analysis showed that, after adjusting for age, gender, race, education level, diabetes, hyperlipidemia, hypertension, smoking history and drinking history, a high level of MRR was independently associated with a reduced risk of stroke [Q2 vs. Q1: odds ratio (OR)=0.986, 95% confidence interval (CI) (0.976, 0.996), P=0.005; Q3 vs. Q1: OR=0.986, 95%CI (0.975, 0.996), P=0.008; Q4 vs. Q1: OR=0.984, 95%CI (0.974, 0.994), P=0.002]. Conclusions The higher the MRR, the lower the risk of stroke. A higher MRR level provides a protective effect against stroke, and the MRR index has potential value in the prevention and management of stroke.
