Magnetic Resonance Imaging Features and Pathologic Basis of Primary Central Nervous System Lymphoma_West China Medical Journal

Authors：

WANG Chenglong , ZHAI Shaohua , ZHOU Haiying.

Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P. R. China;

Corresponding?author：

Keywords：

原發性腦淋巴瘤; 磁共振成像; 診斷; 病理

DOI：

10.7507/1002-0179.20130538

Video：

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目的　探討原發性腦淋巴瘤的MRI表現及病理基礎，提高對腦原發性淋巴瘤的認識。方法　回顧分析2010年1月－2012年5月28例確診為腦原發性淋巴瘤的MRI影像特征及臨床病理資料。結果　28例患者，共發現36個病灶，幕上病灶34個，幕下病灶2個；MRI平掃；32個病灶在T1WI、T2WI腫瘤實質表現為等信號；4個病灶內出現液化壞死（其中1個病灶呈明顯囊變），信號不均。MRI增強掃描：35個腫瘤病灶實質部分均勻強化，1個病灶呈環形強化。病理類型均為彌漫性大B細胞非霍奇金淋巴瘤。結論　原發性腦淋巴瘤具有較典型的MRI影像特征，可在術前明確診斷。

Citation： WANG Chenglong,ZHAI Shaohua,ZHOU Haiying.. Magnetic Resonance Imaging Features and Pathologic Basis of Primary Central Nervous System Lymphoma. West China Medical Journal, 2013, 28(11): 1704-1707. doi: 10.7507/1002-0179.20130538 Copy

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2.	Hartmann M, Sailor K. Primary malignant lymphoma of the brain[J]. Radiol, 1997, 37(1): 42-50．.
3.	孫文勇, 樓瑛, 張谷. 原發性中樞神經系統淋巴瘤臨床病理與免疫組化研究[J]. 中國腫瘤, 2003, 12(7): 427-428.
4.	項威, 趙剛, 李彬, 等. 原發性中樞神經系統惡性淋巴瘤的診斷及治療[J]. 現代腫瘤學, 2010, 11(1): 152-154.
5.	康莊 , 鄒艷, 唐文杰. 免疫正常人原發性腦淋巴瘤的MRI表現[J]. 中華神經醫學雜志, 2009, 7(18): 712-714.
6.	Schlegel U. Primary CNS lymphoma[J]. Ther Adv Neurol Disord, 2009, 2(2): 93-104.
7.	Shenkier TN, Blay JY, O’ neill BP, et al. Primary CNS lymphoma of T-cell origin: a descriptive analysis from the international primary CNS lymphoma collaborative group[J]. J Clin Oncol, 2005, 23(10): 2233-2239.
8.	Sierra del Rio M, Rousseau A, Soussain C, et al. Primary CNS lymphoma in immunocompetent patients[J]. Oncologist, 2009, 14(5): 526-539.
9.	張衛東, 吳沛宏, 謝穿淼, 等. 9例腦原發性淋巴瘤的MRI影像特征[J]. 癌癥雜志, 2007, 26(7): 775-777.
10.	Schwaighofer BW, Hesselink JR, Press GA. Primary intracranial CNS lymphoma: MR manifeatations[J]. AJNR Am J Neuroradiol, 1989, 10(4): 725-729.
11.	劉玲, 鄧開鴻, 寧剛. 原發性中樞神經系統淋巴瘤的CT及MRI表現[J]. 華西醫學, 2010, 25(3): 560-563.
12.	Nakamura M, Shimada K, Ishida E, et al. Histopathology, pathogenesis and molecular genetics in primary central nervous system lymphomas[J]. Histol Histopathol, 2004, 19(1): 211-219.

1. 　Coré TR, Manns A, Hardy CR, et al. Epidemiology of brain lymphoma among people with or without acquired immunodeficiency syndrome. AIDS/Cancer Study Group[J]. J Natl Cancer Inst, 1996, 88(3): 675-679.
2. 　Hartmann M, Sailor K. Primary malignant lymphoma of the brain[J]. Radiol, 1997, 37(1): 42-50．.
3. 　孫文勇, 樓瑛, 張谷. 原發性中樞神經系統淋巴瘤臨床病理與免疫組化研究[J]. 中國腫瘤, 2003, 12(7): 427-428.
4. 　項威, 趙剛, 李彬, 等. 原發性中樞神經系統惡性淋巴瘤的診斷及治療[J]. 現代腫瘤學, 2010, 11(1): 152-154.
5. 　康莊 , 鄒艷, 唐文杰. 免疫正常人原發性腦淋巴瘤的MRI表現[J]. 中華神經醫學雜志, 2009, 7(18): 712-714.
6. 　Schlegel U. Primary CNS lymphoma[J]. Ther Adv Neurol Disord, 2009, 2(2): 93-104.
7. 　Shenkier TN, Blay JY, O’ neill BP, et al. Primary CNS lymphoma of T-cell origin: a descriptive analysis from the international primary CNS lymphoma collaborative group[J]. J Clin Oncol, 2005, 23(10): 2233-2239.
8. 　Sierra del Rio M, Rousseau A, Soussain C, et al. Primary CNS lymphoma in immunocompetent patients[J]. Oncologist, 2009, 14(5): 526-539.
9. 　張衛東, 吳沛宏, 謝穿淼, 等. 9例腦原發性淋巴瘤的MRI影像特征[J]. 癌癥雜志, 2007, 26(7): 775-777.
10. 　Schwaighofer BW, Hesselink JR, Press GA. Primary intracranial CNS lymphoma: MR manifeatations[J]. AJNR Am J Neuroradiol, 1989, 10(4): 725-729.
11. 　劉玲, 鄧開鴻, 寧剛. 原發性中樞神經系統淋巴瘤的CT及MRI表現[J]. 華西醫學, 2010, 25(3): 560-563.
12. 　Nakamura M, Shimada K, Ishida E, et al. Histopathology, pathogenesis and molecular genetics in primary central nervous system lymphomas[J]. Histol Histopathol, 2004, 19(1): 211-219.

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Magnetic Resonance Imaging Features and Pathologic Basis of Primary Central Nervous System Lymphoma

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