The Value of Multi-voxel Proton Magnetic Resonance Spectroscopy Imaging in Assessing the Degree of Glioma Resection_West China Medical Journal

Authors：

LI Xiuli ,  XU Guohui , REN Jing , YANG Yujie , WANG Min , ZHOU Peng , CAO Ying.

Department of Radiology, Sichuan Cancer Hospital, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

XU Guohui, Email: lixiuli217814@163.com

Keywords：

磁共振波譜; 膠質瘤; 術后; 切除程度

DOI：

10.7507/1002-0179.20130539

Video：

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目的　探討3D-多體素磁共振波譜（MRS）在評估腦膠質瘤手術切除程度的價值。方法　對2011年6月－2012年4月32例腦膠質瘤患者術后行常規MRI及MRS檢查，測定分析手術周邊區域主要代謝產物N-乙酰天門冬氨酸（NAA）、膽堿（Cho）、肌酸（Cr）、Cho/NAA、Cho/Cr及NAA/Cr比值，對術后膠質瘤切除程度進行評價。同時通過術后病理檢查結果評估腫瘤切除程度，再與MRS評估結果相比較。結果　32例中病理評估為9例全切除，23例為大部分切除；MRS評估為11例全切除，21例為大部分切除，評估結果與術后病理評估結果差異無統計學意義（P＞0.05）。結論　MRS可以無創評價膠質瘤切除程度，為膠質瘤預后判定及進一步治療提供了重要的依據。

Citation： LI Xiuli,XU Guohui,REN Jing,YANG Yujie,WANG Min,ZHOU Peng,CAO Ying.. The Value of Multi-voxel Proton Magnetic Resonance Spectroscopy Imaging in Assessing the Degree of Glioma Resection. West China Medical Journal, 2013, 28(11): 1708-1711. doi: 10.7507/1002-0179.20130539 Copy

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1. 　Horská A, Barker PB, Imaging of brain tumors: MR Spectroscopy and metabolic imaging[J]. Neuroimaging Clin N Am, 2010, 20(3): 293-310.
2. 　魏海港, 李傳亭. 氫質子磁共振波譜成像在腦腫瘤中的臨床應用[J].醫學像學雜志, 2006, 16(8): 839-842.
3. 　Croteau D, Scarpace L, Hearshen D, et al. Correlation between magnetic resonance spectroscopy imaging and image-guided biopsies: semiquantitative and qualitative histopathological analyses of patients with untreated glioma[J]. Neurosurgery, 2001, 49(4): 823-829.
4. 　紀邦啟, 宋磊, 劉斌. 1H-MRS 在腦膠質瘤診斷及分級中的應用[J]. 中國中西醫結合影像學雜志, 2008, 6(4): 247-250.
5. 　Arnold DL, Shoubridge EA, Villemure JG, et al. Proton and phosphorus magnetic resonance spectroscopy of human astrocytomas in vivo. Preliminary observations on tumor grading[J]. NMR Biomed 1990, 3(4): 184-189.
6. 　Barker PB. N-acetyl aspartate: a neuronal marker?[J]. Ann Neurol, 2001, 49(4): 423-424.
7. 　Yamasaki F, Kurisu k, Kajiwara Y, et al. Magnetic resonance spectroscopic detection of lactate is predictive of a poor prognosis in patients with diffuse intrinsic pontine glioma[J]. Neuro-Oncol, 2011, 13(7): 791-801.
8. 　Florian CL, Preece NE, Bhakoo KK, et al. Cell type specific finger printing of meningioma and meningiomal cells by proton nuclear magnetic resonance spectroscopy[J]. Cancer Res, 1995, 55(1): 420-424.
9. 　Payne GS, Leach MO. Applications of magnetic resonance spectroscopy in radiotherapy treatment planning[J]. Br J Radiol, 2006(79): S16-S26.
10. 　Robertson PL. Advances in treatment of pediatric brain tumors. NeuroRx, 2006, 3(2): 276-291.
11. 　Burtscher IM, Skagerberg G, Geijer B, et al. Proton MR spectroscopy and preoperative diagnostic accuracy: an evaluation of intracranial mass lesions characterized by stereotactic biopsy findings[J]. AJNR, 2000, 21(1): 84-93.
12. 　Narayana A, Chang J, Thakur S, et al. Use of MR spectroscopy and functional imaging in the treatment planning of gliomas[J]. Br J Radiol 2007, 80(953): 374-354.
13. 　Di Costanzo A, Scarabino T, Trojsi F, et al. Multiparametric 3T MR approach to the assessment of cerebral gliomas: tumor extent and malignancy[J]. Neuroradiology, 2006, 48(9): 622-631.

West China Medical Journal

The Value of Multi-voxel Proton Magnetic Resonance Spectroscopy Imaging in Assessing the Degree of Glioma Resection

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