Change of Nitric Oxide in the Exhaled Gas of Teenager Patients with Allergic Rhinitis Accompanied with Asthma Treated by Budesonide Formoterol Inhalant_West China Medical Journal

Authors：

 LIUGui-tao ^1,2 , TAOYing ¹ ,  WANGQian ³ , WEIYan-hua ² , NIELi-ping ² , YINWan-bin ² , WUYan-pin ² , WANGXiao-hua ² , YUWen-long ²

1. Occupational Diseases Prevention and Treatment Institution, the Fifth Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang 830011, P. R. China;
2. Medical School, Xinjiang Medical University, Urumqi, Xinjiang 830011, P. R. China;
3. College of Public Health; Xinjiang Medical University, Urumqi, Xinjiang 830011, P. R. China;

Corresponding?author：

WANGQian, Email: 387788761@qq.com

Keywords：

Budesonide formoterol inhalant; Allergic rhinitis; Bronchial asthma; Nitric oxide in the exhaled gas

DOI：

10.7507/1002-0179.20150077

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Objective To observe the effect of Budesonide formoterol inhalant on teenager patients with allergic rhinitis accompanied with asthma. Methods Forty-five teenager patients with allergic rhinitis accompanied with asthma treated between January 2012 and December 2013 were randomly divided into general treatment group, budesonide group and budesonide formoterol group, with 15 patients in each. Another 15 subjects undergoing physical examination were designated as the control group. Besides routine treatment, the budesonide group was also treated with budesonide inhalation at 100-200 μg twice a day, and the budesonide formoterol group was also treated with budesonide formoterol inhalation at 160 μg and 4.5 μg twice a day. The course of treatment lasted for four weeks. The patients were followed up for four weeks after the use of medicine halted. After treatment, exhaled nitric oxide (NO) examination were performed. Results The amount of NO in the exhaled gas in all the three treatment groups were significantly different from the control group (P<0.05), and it was also significantly different between the Budesonide group and the budesonide formoterol group (P<0.05). Conclusion Budesonide formoterol inhalant has a good effect on teenager patients with allergic rhinitis accompanied with asthma in terms of improving exhaled NO.

Citation： LIUGui-tao, TAOYing, WANGQian, WEIYan-hua, NIELi-ping, YINWan-bin, WUYan-pin, WANGXiao-hua, YUWen-long. Change of Nitric Oxide in the Exhaled Gas of Teenager Patients with Allergic Rhinitis Accompanied with Asthma Treated by Budesonide Formoterol Inhalant. West China Medical Journal, 2015, 30(2): 246-249. doi: 10.7507/1002-0179.20150077 Copy

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15.	王曉君. 支氣管哮喘合并變應性鼻炎共治的臨床觀察[D]. 唐山:華北煤炭醫學院, 2010.
16.	杜娟, 陳冰蓉, 周建, 等. 孟魯司特治療兒童變應性鼻炎與哮喘的療效觀察[J]. 中國現代應用藥學, 2008, 25(增刊1):679-681.
17.	馬敏, 李奕, 倪殿濤, 等. 變應性鼻炎合并哮喘患者糖皮質激素鼻吸入治療對哮喘發作的影響[J]. 武警醫學, 2003, 14(9):521-524.
18.	王棟. 不同藥物對小兒哮喘的療效對比研究[J]. 華西醫學, 2010, 25(2):345-346.

1. 韓德民, 張羅, 黃丹, 等. 我國11個城市變應性鼻炎自報患病率調查[J]. 中華耳鼻咽喉頭頸外科雜志, 2007, 42(5):378-384.
2. Guerra S, Sherrill DL, Martinez FD, et al. Rhinitis as an Independent risk factor for adultonset asthma[J]. J Allergy Clin Immunol, 2002, 109(3):419-425.
3. Gaugris S, Sazonov-Kocevar V, Thomas M. Burden of concomitant allergic rhinitis in adults with asthma[J]. J Asthma, 2006, 43(1):1-7.
4. 王惠嫵, 向陽冰, 陳璇, 等. 新疆地區哮喘與變應性鼻炎患者過敏原檢測及相關性分析[J]. 新疆醫科大學學報, 2007, 30(10):1086-1088.
5. 楊柳, 劉世喜. 變應性鼻炎的特異性免疫治療[J]. 華西醫學, 2012, 27(10):1582-1584.
6. 張虹婷, 余蓉, 孟娟, 等. 變應性鼻炎皮膚點刺試驗分析[J]. 華西醫學, 2014, 29(2):334-336.
7. 唐秀純, 周云霞. 小兒哮喘健康教育的效果評價[J]. 華西醫學, 2010, 25(8):1561-1562.
8. 奚玲. 過敏性鼻炎未成年患者常見吸入性變應原分析[J]. 華西醫學, 2014, 29(4):710-713.
9. 謝紅. 卡介菌多糖核酸治療小兒咳嗽變異性哮喘[J]. 華西醫學, 2009, 24(2):421-422.
10. 王曉霞, 蘇嫻, 包勇. 呼出氣一氧化氮檢測在支氣管哮喘中的應用[J]. 華西醫學, 2010, 25(9):1765-1768.
11. 胡鑫, 沈唯薇. 難治性哮喘中Th1/Th2失衡機制[J]. 華西醫學, 2011, 26(9):1428-1431.
12. 彭向東, 何晟. 支氣管哮喘合并過敏性鼻炎的中西醫結合治療[J]. 臨床和實驗醫學雜志, 2013, 12(14):1118-1119.
13. Rottem M. Allergic rhinitis and its impaction asthma[J]. Harefuah, 2010, 149(6):402-403.
14. 孫勇, 蔣捍東. 過敏性鼻炎與哮喘患者血清黏附分子及白細胞介素的研究[J]. 中國醫藥, 2009, 4(6):405-407.
15. 王曉君. 支氣管哮喘合并變應性鼻炎共治的臨床觀察[D]. 唐山:華北煤炭醫學院, 2010.
16. 杜娟, 陳冰蓉, 周建, 等. 孟魯司特治療兒童變應性鼻炎與哮喘的療效觀察[J]. 中國現代應用藥學, 2008, 25(增刊1):679-681.
17. 馬敏, 李奕, 倪殿濤, 等. 變應性鼻炎合并哮喘患者糖皮質激素鼻吸入治療對哮喘發作的影響[J]. 武警醫學, 2003, 14(9):521-524.
18. 王棟. 不同藥物對小兒哮喘的療效對比研究[J]. 華西醫學, 2010, 25(2):345-346.

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West China Medical Journal

Change of Nitric Oxide in the Exhaled Gas of Teenager Patients with Allergic Rhinitis Accompanied with Asthma Treated by Budesonide Formoterol Inhalant

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