Clinical Observation of Terminating Mid-pregnancy by Intra-amniotic Injection of Ethacridine with Cook Cervical Ripening Balloon_West China Medical Journal

Authors：

 GAOXue-mei , ZHOUPing , ZHUYi-lin ,  HEYi

Department of Obstetrics, Wuhan NO. 1 Hospital, Wuhan, Hubei 430022, P. R. China;

Corresponding?author：

HEYi, Email: zxghy@163.com

Keywords：

Induction labor; Ethacridine; Cook cervical ripening balloon

DOI：

10.7507/1002-0179.20150135

Video：

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Objective To probe into the clinical effects of intra-amniotic injection of ethacridine with Cook cervical ripening balloon in terminating mid-pregnancy. Methods A total of 150 mid-pregnant women who required induction of labor from January 2011 to December 2012 were randomly divided into two groups: observation group (intra-amniotic injection of ethacridine with Cook cervical ripening balloon) and control group (intra-amniotic injection of ethacridine). Results The time of labor induction was obviously shorter in the observation group than the control group [the time from using ethacridine to contraction: （29.68±4.17） vs (33.60±5.38) hours, P<0.05; total process: (7.63±2.30) vs (9.86±3.20) hours, P<0.05], and the residual rate of placental membranes [28.6% (10/35) vs 56.4%(22/39), P<0.05] was significantly lower. But there was no significant difference in postpartum hemorrhage [(81.60±17.64) vs (83.82±15.08 ) mL, P>0.05] and rate of success [100.0% (35/35) vs 94.9% (37/39), P>0.05]. Conclusion Terminating mid-pregnancy by intra-amniotic injection of ethacridine with Cook cervical ripening balloon has the advantages of shorter time and less pain, which deserves clinical application widely.

Citation： GAOXue-mei, ZHOUPing, ZHUYi-lin, HEYi. Clinical Observation of Terminating Mid-pregnancy by Intra-amniotic Injection of Ethacridine with Cook Cervical Ripening Balloon. West China Medical Journal, 2015, 30(3): 477-479. doi: 10.7507/1002-0179.20150135 Copy

1.	Kehl S, Welzel G, Ehard A, et al. Women's acceptance of a double-balloon device as an additional method for inducing labour[J]. Eur J Obstet Gynecol Reprod Biol, 2013, 168(1):30-35.
2.	Atad J, Hallak M, Auslender R, et al. Arandomized com-parison of prostaglandin E₂, oxytocin, and double-balloon devicein inducing labor[J]. Obstet Gynecol, 1996, 87(2):223-227.
3.	Vellekoop J, Vrouenraets FP, Van DJ, et al. Indacations and results of labor induction in nulliparous women:an interview among obstetricians, residents and clinical midwives[J]. Eur J Obstet Gynecol Reprod Biol, 2009, 146(2):156-159.
4.	Zhuang YL, Chen XY, Huang LL. Mifepristone may shorten the induction-to-abortion time for termination of second-trimester pregnancies by ethacridine lactate[J]. Contraception, 2012, 85(2):211-217.
5.	孫燕茹. 米非司酮與米索前列醇聯合水囊用于中期引產的臨床觀察[J]. 中國醫藥導報, 2011, 8(1):153-154.
6.	莫言香, 徐紅梅, 李娜, 等. 欣母佩用于產后出血治療的臨床效果分析[J]. 中國婦幼保健, 2012, 27(3):343-345.
7.	ACOG Committee on Practice Bulletins-Obstetrics. ACOG practice bulletin No.107:induction of labor[J]. Obstet Gynecol, 114(2):386-397.
8.	Society of Obstetricians and Gynaecologists of Canada. SOGC clinical practice guidelines. Guidelines for vaginal birth after previous caesarean birth. Number 155(Replaces guideline Number 147), February 2005[J]. Int J Gynaecol Obstet, 2005, 89(3):319-331.
9.	范翠芳, 張正娥, 明蕾, 等. COOK雙球囊與縮宮素促宮頸成熟并引產的對照研究[J]. 重慶醫學, 2012, 41(36):3820-3822.
10.	竇娜, 周紅輝, 高志英. Cook宮頸擴張球囊用于妊娠晚期促宮頸成熟的臨床研究[J]. 軍醫進修學院學報, 2012, 33(8):836-838.
11.	Cromi A, Ghezzi F, Uccella S, et al. A randomized trial of preinduction cervical ripening:dinoprostone vaginal insert versus double-balloon catheter[J]. Am J Obstet Gynecol, 2012, 207(2):1-7.
12.	Boyon C, Monsarrat N, Clouqueur E, et al. Cervical ripening:is there an advantage for a double-balloon device in labor induction?[J]. Gynecol Obstet Fertil, 2014, 42(10):674-680.
13.	Jozwiak M, Oude RK, Benthem M, et al. Foley catheter versus vaginal prostaglandin E₂ gel for induction of labour at term (PROBAAT trial):an open-label, randomised controlled trial[J]. Lancet, 2011, 378(9809):2095-2103.
14.	陳飛, 劉欣燕, 彭萍, 等. 地諾前列酮栓配伍依沙吖啶與單用依沙丫啶在中期妊娠引產中的有效性和安全性比較[J]. 中國醫學科學院學報, 2010, 32(5):505-508.
15.	Landon MB, Hauth JC, Leveno KJ, et al. Maternal and perinatal outcomes associated with a trial of labor after prior cesarean delivery[J]. N Engl J Med, 2004, 351(25):2581-2589.
16.	Ravasia DJ, Wood SL, Pollard JK. Uterine rupture during induced trial of labor among women with previous cesarean delivery[J]. Am J Obstet Gynecol, 2000, 183(5):1176-1179.
17.	Bujold E, Blackwell SC, Gauthier RJ. Cervical ripening with transcervical Foley catheter and the risk of uterine rupture[J]. Obstet Gynecol, 2004, 103(1):18-23.
18.	楊茗, 李云秀, 柏智, 等. 人工破膜聯合COOK球囊在足月引產中的療效觀察[J]. 當代醫學, 2013, 19(30):27-28.

1. Kehl S, Welzel G, Ehard A, et al. Women's acceptance of a double-balloon device as an additional method for inducing labour[J]. Eur J Obstet Gynecol Reprod Biol, 2013, 168(1):30-35.
2. Atad J, Hallak M, Auslender R, et al. Arandomized com-parison of prostaglandin E₂, oxytocin, and double-balloon devicein inducing labor[J]. Obstet Gynecol, 1996, 87(2):223-227.
3. Vellekoop J, Vrouenraets FP, Van DJ, et al. Indacations and results of labor induction in nulliparous women:an interview among obstetricians, residents and clinical midwives[J]. Eur J Obstet Gynecol Reprod Biol, 2009, 146(2):156-159.
4. Zhuang YL, Chen XY, Huang LL. Mifepristone may shorten the induction-to-abortion time for termination of second-trimester pregnancies by ethacridine lactate[J]. Contraception, 2012, 85(2):211-217.
5. 孫燕茹. 米非司酮與米索前列醇聯合水囊用于中期引產的臨床觀察[J]. 中國醫藥導報, 2011, 8(1):153-154.
6. 莫言香, 徐紅梅, 李娜, 等. 欣母佩用于產后出血治療的臨床效果分析[J]. 中國婦幼保健, 2012, 27(3):343-345.
7. ACOG Committee on Practice Bulletins-Obstetrics. ACOG practice bulletin No.107:induction of labor[J]. Obstet Gynecol, 114(2):386-397.
8. Society of Obstetricians and Gynaecologists of Canada. SOGC clinical practice guidelines. Guidelines for vaginal birth after previous caesarean birth. Number 155(Replaces guideline Number 147), February 2005[J]. Int J Gynaecol Obstet, 2005, 89(3):319-331.
9. 范翠芳, 張正娥, 明蕾, 等. COOK雙球囊與縮宮素促宮頸成熟并引產的對照研究[J]. 重慶醫學, 2012, 41(36):3820-3822.
10. 竇娜, 周紅輝, 高志英. Cook宮頸擴張球囊用于妊娠晚期促宮頸成熟的臨床研究[J]. 軍醫進修學院學報, 2012, 33(8):836-838.
11. Cromi A, Ghezzi F, Uccella S, et al. A randomized trial of preinduction cervical ripening:dinoprostone vaginal insert versus double-balloon catheter[J]. Am J Obstet Gynecol, 2012, 207(2):1-7.
12. Boyon C, Monsarrat N, Clouqueur E, et al. Cervical ripening:is there an advantage for a double-balloon device in labor induction?[J]. Gynecol Obstet Fertil, 2014, 42(10):674-680.
13. Jozwiak M, Oude RK, Benthem M, et al. Foley catheter versus vaginal prostaglandin E₂ gel for induction of labour at term (PROBAAT trial):an open-label, randomised controlled trial[J]. Lancet, 2011, 378(9809):2095-2103.
14. 陳飛, 劉欣燕, 彭萍, 等. 地諾前列酮栓配伍依沙吖啶與單用依沙丫啶在中期妊娠引產中的有效性和安全性比較[J]. 中國醫學科學院學報, 2010, 32(5):505-508.
15. Landon MB, Hauth JC, Leveno KJ, et al. Maternal and perinatal outcomes associated with a trial of labor after prior cesarean delivery[J]. N Engl J Med, 2004, 351(25):2581-2589.
16. Ravasia DJ, Wood SL, Pollard JK. Uterine rupture during induced trial of labor among women with previous cesarean delivery[J]. Am J Obstet Gynecol, 2000, 183(5):1176-1179.
17. Bujold E, Blackwell SC, Gauthier RJ. Cervical ripening with transcervical Foley catheter and the risk of uterine rupture[J]. Obstet Gynecol, 2004, 103(1):18-23.
18. 楊茗, 李云秀, 柏智, 等. 人工破膜聯合COOK球囊在足月引產中的療效觀察[J]. 當代醫學, 2013, 19(30):27-28.

West China Medical Journal

Clinical Observation of Terminating Mid-pregnancy by Intra-amniotic Injection of Ethacridine with Cook Cervical Ripening Balloon

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