Cross-sectional Study on the Relationship between Syndromes of Traditional Chinese Medicine and Lung Function in Patients with Chronic Obstructive Pulmonary Disease at Stable Phase_West China Medical Journal

Authors：

 QUBo , ZHOUWei ,  MAOBing

Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

MAOBing, Email: maobing2013@yeah.net

Keywords：

Chronic obstructive pulmonary disease; Stable phase; Syndrome of traditional Chinese medicine; Lung function

DOI：

10.7507/1002-0179.20150533

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective ?To investigate the relationship between syndromes of traditional Chinese medicine (TCM) and lung function in patients with chronic obstructive pulmonary disease (COPD) at stable phase. Methods Based on diagnostic criterion of TCM, five groups of symptoms of TCM about stable COPD were established including lung Qi deficiency, lung and spleen Qi deficiency, lung and kidney Qi deficiency, lung Spleen Kidney Qi deficiency, and deficiency of both Qi and Yin. A total of 300 cases which were up to the standard were differentiated into 5 groups by the symptoms. Some basic details and lung function of the patients were recorded, and then statistical analysis was performed to analyze the differences of lung function among groups. Results Forced expiratory volume in the first second in descending order was lung Qi deficiency group, lung and spleen Qi deficiency group, lung and kidney Qi deficiency group, and lung spleen kidney Qi deficiency group (P<0.05). Conclusion These findings suggest that with the progressing of COPD, the symptom type of TCM for COPD patients at stable phase may vary from lung Qi deficiency to lung and spleen Qi deficiency, or to lung and kidney Qi deficiency, and even lung, spleen and kidney Qi deficiency. Lung function tests help reveal substance and pathogenesis of TCM syndromes of patients with stable COPD, and provide evidence for the clinical syndrome.

Citation： QUBo, ZHOUWei, MAOBing. Cross-sectional Study on the Relationship between Syndromes of Traditional Chinese Medicine and Lung Function in Patients with Chronic Obstructive Pulmonary Disease at Stable Phase. West China Medical Journal, 2015, 30(10): 1853-1856. doi: 10.7507/1002-0179.20150533 Copy

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1. 中華醫學會呼吸病學分會慢性阻塞性肺疾病學組. 慢性阻塞性肺疾病診治指南(2007年修訂版)[J]. 中華內科雜志, 2007, 30(3): 254-261.
2. Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease (updated 2015)[EB/OL]. (2015-04-02)[2015-04-06]. http://www.goldcopd.org/uploads/users/files/GOLD_Report_2015_Apr2.pdf.
3. 劉建, 劉忠義, 趙文鵬, 等. 中藥治療慢性阻塞性肺疾病穩定期淺析[J]. 河北中醫, 2011, 33(2):224.
4. 劉羽雄. 慢性阻塞性肺疾病穩定期中醫干預療效評價結構的分析[D]. 廣州:廣州中醫藥大學, 2011.
5. 鄭筱萸. 中藥新藥臨床研究指導原則[M]. 北京:中國醫藥科技出版社, 2002:53-66.
6. 沈自尹. 中醫虛證辨證參考標準[J]. 中西醫結合雜志, 1983, 6(2): 117.
7. 譚光波, 柏正平, 胡學軍. 冬病夏治敷貼療法對COPD穩定期患者生活質量的影響[C]//第十次全國中西醫結合防治呼吸系統疾病學術研討會論文集. 杭州:中國中西醫結合學會, 2009:77-80.
8. 卓宋明, 徐文莉, 梁珊瑚, 等. 慢性阻塞性肺疾病患者T 淋巴細胞亞群凋亡與Fas、FasL、Bcl-2表達的關系[J]. 中華臨床醫師雜志: 電子版, 2011, 5(6):1554-1560.
9. 陳明靜, 吳維平. COPD中醫病因病機及辨證分型研究進展[J]. 光明中醫, 2009, 24(1):168-169.
10. 吳啟相. 慢性阻塞性肺疾病的中醫辨治體會[J]. 中國中醫急癥, 2011, 20(8):1358-1359.
11. 徐雯潔, 王天芳, 王智瑜, 等. 基于現代文獻的慢性阻塞性肺疾病中醫證候及證候要素的研究[J]. 中華中醫藥雜志, 2008, 23(1):19-22.
12. 吳蕾, 林琳, 許銀姬, 等. 慢性阻塞性肺疾病證候規律中的五臟關系探討[J]. 新中醫, 2010, 42(6):84-85.
13. 尹寶伶. COPD篩查問卷與肺功能檢查診斷COPD的相關性研究[D]. 北京:北京中醫藥大學, 2013.
14. 麻麗麗. 慢性阻塞性肺疾病中醫證型與肺功能、生活質量的相關性研究[D]. 太原:山西中醫學院, 2013.
15. 陳瑾. COPD患者中醫辨證分型與有關指標相關性分析[J]. 遼寧中醫藥大學學報, 2006, 8(4):7-8.
16. 馬惠杰, 楊文杰, 陶家駒. ECT肺通氣血流顯像及肺功能檢查在緩解期COPD中西醫結合診斷分型中的應用研究[J]. 河北中醫, 2004, 26(5):337-338.
17. 左萍. 補肺益腎丸對COPD穩定期患者呼吸功能的影響[J]. 中國中醫藥科技, 2010, 17(3):258-259.

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West China Medical Journal

Cross-sectional Study on the Relationship between Syndromes of Traditional Chinese Medicine and Lung Function in Patients with Chronic Obstructive Pulmonary Disease at Stable Phase

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