Study on the Seasonal Distribution of Multidrug-resistant Organism in Neurosurgical Intensive Care Unit_West China Medical Journal

Authors：

 LüYu , XiangQian , WeiDaoqiong , WuJiayu , ZhouZhonghua , LiuHua ,  WangHui

Nosocomial Infection Management Office, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P. R. China;

Corresponding?author：

WangHui, Email: 1139181198@qq.com

Keywords：

Neurosurgical intensive care unit; Multidrug-resistant organism; Surveillance; Seasonal

DOI：

10.7507/1002-0179.201600111

Video：

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Objective To analyze epidemic characteristics of multidrug-resistant organism (MDRO) in Neurosurgical Intensive Care Unit (NSICU), and to analyze the status of infection and colonization, in order to provide reference for constituting intervention measures. Methods Patients who stayed in NSICU during January 2014 to April 2015 were actively monitored for the MDRO situation. Results A total of 218 MDRO pathogens were isolated from 159 patients, and 42 cases were healthcare-associated infections (HAI) among 159 patients. The Acinetobacter baumannii was the most common one in the isolated acinetobacter. Colonization rate was positively correlated with the incidence of HAI. From January to December, there was a significantly increase in the colonization rate, but not in the incidence of HAI. Conclusion The main MDRO situation is colonization in NSICU. The obvious seasonal variation makes the HAI risk at different levels. So it is necessary that full-time and part-time HAI control staff be on alert, issue timely risk warning, and strengthen risk management. The Acinetobacter baumannii has become the number one target for HAI prevention and control in NSICU, so their apparent seasonal distribution is worthy of more attention, and strict implementation of HAI prevention and control measures should be carried out.

Citation： LüYu, XiangQian, WeiDaoqiong, WuJiayu, ZhouZhonghua, LiuHua, WangHui. Study on the Seasonal Distribution of Multidrug-resistant Organism in Neurosurgical Intensive Care Unit. West China Medical Journal, 2016, 31(3): 403-408. doi: 10.7507/1002-0179.201600111 Copy

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1. 文細毛, 任南, 吳安華, 等. 全國醫院感染監控網細菌耐藥情況及變化趨勢[J]. 中國感染控制雜志, 2009, 8(6):389-396, 408.
2. 劉華, 羅蓓蓓. ICU醫院感染多重耐藥菌類型、耐藥性及感染相關因素研究[J]. 實用醫院臨床雜志, 2009, 6(3):140-142.
3. 李文郎, 唐恒鋒, 王文杰, 等. 神經外科ICU與普通神經外科醫院感染病原菌及耐藥性對比研究[J]. 中國醫藥導刊, 2011, 13(11):1957-1958, 1939.
4. 李倩, 武元星, 唐明忠, 等. 神經外科重癥監護病房細菌流行及耐藥性的20年監測[J]. 臨床神經外科雜, 2016, 13(1):49-59.
5. 朱愛萍, 朱彥, 王新民, 等. 多重耐藥菌感染監測與預防控制措施[J]. 醫藥論壇雜志, 2010, 31(20):175-176.
6. 王宏沛, 孟靈, 王鴻瑋, 等. 多重耐藥菌監測與易感因素的臨床研究[J]. 蘭州大學學報:醫學版, 2005, 31(2):55-56.
7. 孫曉, 張平, 華衛紅, 等. 多重耐藥菌醫院感染相關因素與控制[J]. 現代醫藥衛生, 2009, 25(16):2535-2536.
8. 中華人民共和國衛生部. WS/T 312-2009醫院感染監測規范[S]. 2009.
9. 中華人民共和國衛生部. 關于印發醫院感染診斷標準(試行) 的通知[EB/OL]. (2001-11-07)[2014-01-01]. http://www.nhfpc.gov.cn/yzygj/s3593/200804/e19e4448378643a09913ccf2a055c79d.shtml.
10. 中華人民共和國衛生和計劃生育委員會. 醫院感染管理質量控制指標(2015年版)[EB/OL]. (2015-04-10)[2015-05-01]. http://www.nhfpc.gov.cn/ewebeditor/uploadfile/2015/04/20150415094217171.pdf.
11. Richet H. Seasonality in gram-negative and healthcare-associated infections[J]. Clin Microbiol Infect, 2012, 18(10):934-940.
12. Chazan B, Colodner R, Edelstein H, et al. Seasonal variation in Escherichia coli bloodstream infections in northern Israel[J]. Clin Microbiol Infect, 2011, 17(6):851-854.
13. Ramos GP, Rocha JL, Tuon FF. Seasonal humidity may influence Pseudomonas aeruginosa hospital-acquired infection rates[J]. Int J Infect Dis, 2013, 17(9):e757-e761.
14. 王樞群, 張邦燮. 醫院感染學[M]. 重慶:科學技術文獻出版社重慶分社, 1990:50-83.
15. Perencevich EN, Mcgregor JC, Shardell M, et al. Summer peaks in the incidences of Gram-negative bacterial infection among hospitalized patients[J]. Infect Control Hosp Epidemiol, 2008, 29(12):1124-1131.
16. McDonald LC, Banerjee SN, Jarvis WR. Seasonal variation of Acinetobacter infections:1987-1996. Nosocomial infections surveillance system[J]. Clin Infect Dis, 1999, 29(5):1133-1137.
17. 蔣國欽. ICU病人鮑曼不動桿菌定植的流行病學特征及危險因素探討[D]. 蘇州:蘇州大學, 2011.
18. Fournier PE, Richet H. The epidemiology and control of Acinetobacter baumannii in health care facilities[J]. Clin Infect Dis, 2006, 42(5):692-699.
19. Climo MW, Yokoe DS, Warren DK, et al. Effect of daily chlorhexidine bathing on hospital-acquired infection[J]. N Engl J Med, 2013, 368(6):533-542.
20. Dixon JM, Carver RL. Daily chlorohexidine gluconate bathing with impregnated cloths results in statistically significant reduction in central line-associated bloodstream infections[J]. Am J Infect Control, 2010, 38(10):817-821.

West China Medical Journal

Study on the Seasonal Distribution of Multidrug-resistant Organism in Neurosurgical Intensive Care Unit

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