Research on the Effect of Prevention and Control Intervention on Multidrug-resistant Organism in A Comprehensive Hospital of the First Grade_West China Medical Journal

Authors：

 LeiXibing ,  ChenLiping , XiaoYaxiong , TangYan , TanMuyang , SunRui

Nosocomial Infection Management Office, the First People's Hospital of Yibin City, Yibin, Sichuan 644000, P. R. China;

Corresponding?author：

ChenLiping, Email: 1837639492@qq.com

Keywords：

Multi-drug resistance; Prevention and control interventions; Evaluation

DOI：

10.7507/1002-0179.201600112

Video：

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Objective To learn the status quo and characteristics of multi-drug resistant organism (MDRO) infection in a comprehensive hospital of the first grade in Sichuan Province, analyze the effect of prevention and control intervention, in order to provide a scientific basis for clinical MDRO prevention and control. Methods We collected MDRO data from January to June 2014 and from January to June 2015 through multi-drug resistance reporting software, and analyzed and compared the infection of MDRO during those two time periods. Then, we evaluated the prevention and control effect of MDRO infection. Results The number of inpatients from January to June 2014 was 24709, among which 813 were detected with MDRO infection. Of those infected patients, 196 had nosocomial infection of MDRO and the other 617 had community infection/colonization. The proportion of nosocomial MDRO infection was 24.10%. The MDRO nosocomial infection case rate was 0.79%. The proportion of community MDRO infection/colonization was 75.90%. The number of inpatients from January to June 2015 was 25329, and 739 of them were found with MDRO infection, of whom 132 had nosocomial infection and 607 community infection/colonization. The proportion of nosocomial MDRO infection was 17.86%. The MDRO nosocomial infection case rate was 0.52%. The proportion of community infection/colonization was 80.14%. Compared with the first half of 2014, the proportion of nosocomial MDRO infection was lower with a statistically significant difference (χ²=9.062, P<0.001), and MDRO nosocomial infection case rate was also significantly lowered (χ²=14.220, P<0.001). There were significant differences between the first half of 2015 and the same period of 2014 in hospital department distribution of MDRO infection, patient infection site distribution and pathogen detection. Conclusion The nosocomial MDRO infection control situation of our hospital is improved after the comprehensive prevention and control interventions, and we should focus on the prevention and control of key departments, important infection sites and major resistant bacteria in the future MDRO hospital infection control work.

Citation： LeiXibing, ChenLiping, XiaoYaxiong, TangYan, TanMuyang, SunRui. Research on the Effect of Prevention and Control Intervention on Multidrug-resistant Organism in A Comprehensive Hospital of the First Grade. West China Medical Journal, 2016, 31(3): 409-413. doi: 10.7507/1002-0179.201600112 Copy

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1. 孫風琳, 田龍飛, 李鶯, 等. 多重耐藥菌主動監測及防控干預的效果研究[J]. 寧夏醫學. 雜志, 2013, 35(11):1102-1103.
2. 高蓮英, 尹繞竹, 李云華. 多重耐藥菌監測分析及控制對策[J]. 醫藥與保健, 2014, 22(10):83-83.
3. 中華人民共和國衛生部. 衛生部辦公廳關于加強多重耐藥菌醫院感染控制工作的通知[EB/OL]. (2008-07-15)[2014-01-01]. http://www.moh.gov.cn/pygj/s3593/200807/7858200369d349b38961902ad5b37778.shtml.
4. 中華人民共和國衛生部衛生部辦公廳關于印發《多重耐藥菌醫院感染預防與控制技術指南(試行)》的通知[EB/OL]. (2011-01-06)[2014-01-01]. http://www.nhfpc.gov.cn/mohyzs/s3594/201101/50487.shtml.
5. 顧忠民, 吳榮華, 中國醫藥科學. PCT在ICU多重耐藥菌MDR的定植與感染鑒別中的應用[J]. 中國醫藥科學, 2012, 11(2):90-91.
6. Schuetz P, Albrich WC, Mueller B. Procalcitonin for diagnosis of infection and guide to antibiotic decisions:past, present and future[J]. BMC Med, 2011, 9(1):107.
7. 中華人民共和國衛生部. WS/T 313-2009 醫務人員手衛生規范[S]. 2009.
8. 中華人民共和國衛生部. 抗菌藥物臨床應用管理辦法[EB/OL]. (2012-08-01)[2012-02-13]. http://www.moh.gov.cn/mohyzs/s3584/201205/54645.shtml.
9. 中華人民共和國衛生部, 國家中醫藥管理局, 總后衛生部. 抗菌藥物臨床應用指導原則[EB/OL]. (2014-08-19)[2015-01-01]. http://www.sfda.gov.cn/wyf04285/2004285.zip.
10. 李輝, 孫曉輝, 歐柳紅. 綜合ICU多重耐藥菌感染的監測及綜合干預研究[J]. 中國感染控制雜志, 2013, 12(3):196-198.
11. 舒菊香. 淺談醫院感染管理防控方面存在的問題和對策[J]. 中國中醫藥咨訊, 2010, 2(18):77-78.
12. 周健, 孟軍, 江淑芳. 綜合ICU多重耐藥菌感染的分析與護理干預[J]. 護士進修雜志, 2012, 27(19):1743-1744.
13. 趙紅霞. 某綜合醫院多重耐藥菌感染類型調查[J]. 中國消毒學雜志, 2015, 32(2):181-182.
14. 劉彩紅, 李福琴, 劉盛楠, 等. 綜合干預措施可降低重癥監護病房多重耐藥菌醫院感染發病率[J]. 中國感染控制雜志, 2015, 8(8):553-556.
15. 李霞, 邢志廣, 王明永. 尿路感染大腸埃希菌的分離鑒定及抗菌藥物選擇[J]. 現代預防醫學, 2011, 38(8):1518-1519.
16. 陳曉娟, 黃建瓊. 燒傷層流病房多重耐藥菌感染的相關因素分析及干預措施[J]. 華西醫學, 2013, 28(10):1486-1488.
17. 陳美戀, 賈會學, 李六億. 多重耐藥菌感染監測及防控現狀綜述[J]. 中國感染控制雜志, 2015, 14(8):571-576.
18. 任麗, 雷霞, 張馨. 某基層醫院泛耐藥鮑曼不動桿菌感染暴發的調查與控制[J]. 中國感染控制雜志, 2015, 14(6):370-373.

West China Medical Journal

Research on the Effect of Prevention and Control Intervention on Multidrug-resistant Organism in A Comprehensive Hospital of the First Grade

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