Observation on the Effect of Glucosamine Hydrochloride Combined with Antiosteoporosis Drugs in the Treatment of Senile Knee Osteoarthritis_West China Medical Journal

Authors：

 WangXinchun

Department of Pain, the First People’s Hospital of Neijiang, Neijiang, Sichuan 641000, P. R. China;

Corresponding?author：

Keywords：

Osteoarthritis, knee; Osteoporosis; Glucosamine hydrochloride

DOI：

10.7507/1002-0179.201600229

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To observe the clinical effect of combined glucosamine hydrochloride and antiosteoporosis drugs in the treatment of senile knee osteoarthritis. Methods A total of 120 patients with osteoarthritis of the knee treated from January 2014 to December 2015 were randomly divided into observation group and control group with 60 cases in each. The observation group received not only oral glucosamine hydrochloride, but calcium D3, alfacalcidol, and sodium phosphate for anti-osteoporosis treatment, while the control group was only given oral glucosamine hydrochloride. Lequesne score, curative effect and adverse drug reactions were compared between the two groups 2, 4, and 6 weeks after the beginning of treatment. Results Within two weeks of treatment, there was no significant difference between the two groups in the effective rate (P ＞ 0.05) . But four and six weeks after treatment, the efficiency in the observation group was significantly higher than that in the control group (χ²=6.806, P ＜ 0.01; χ²=24.762, P ＜ 0.01) . Four and six weeks after treatment, Lequesne score of the observation group was significantly lower than that of the control group (t=2.199, P ＜ 0.05; t=4.748, P ＜ 0.001) . There was no significant difference in terms of adverse reactions between the two groups before and after treatment (χ²=0.617, P ＞ 0.05) . Conclusion Compared with single hydrochloric amino glucose treatment, glucosamine hydrochloride combined with anti-osteoporosis treatment for senile knee osteoarthritis has better treatment effect without increase in adverse drug reactions, and it is worth of clinical application.

Citation： WangXinchun. Observation on the Effect of Glucosamine Hydrochloride Combined with Antiosteoporosis Drugs in the Treatment of Senile Knee Osteoarthritis. West China Medical Journal, 2016, 31(5): 838-840. doi: 10.7507/1002-0179.201600229 Copy

1.	Lingard EA, Mitchell SY, Francis RM, et al. The prevalence of osteoporosis in patients with severe hip and knee osteoarthritis awaiting joint arthroplasty[J]. Age Ageing, 2010, 39(2) : 234-239.
2.	陳鴻儒. 玻璃酸鈉注射液治療膝關節骨關節炎療效觀察[J]. 現代中西醫結合雜志, 2011, 20(4) : 449-450.
3.	曹小燕, 李鳳霞, 葉青. 唑來膦酸鈉抗骨質疏松治療膝骨關節炎的療效觀察[J]. 湖北醫藥學院學報, 2014, 33(1) : 56-58.
4.	Lequesne M. Indices of severity and disease activity for osteoarthritis[J]. Semin Arthritis Rheum, 1991, 20(6, Suppl 2) : 48-54.
5.	余素君, 納世麗, 魏薇, 等. 鹽酸氨基葡萄糖聯合非甾體抗炎藥治療中度膝關節骨關節炎的臨床研究[J]. 現代生物醫學進展, 2015, 15(10) : 1919-1922.
6.	郭世紱. 性激素和細胞因子與骨關節炎及骨質疏松的關系[J]. 國外醫學: 內分泌學分冊, 2003, 23(2) : 98-100.
7.	施桂英. 關節炎概要[M]. 北京: 中國醫藥科技出版社, 2000: 432-433.
8.	Kanzaki N, Saito K, Maeda A, et al. Effect of a dietary supplement containing glucosamine hydrochloride, chondroitin sulfate and quercetin glycosides on symptomatic knee osteoarthritis: a randomized, double-blind, placebo-controlled study[J]. J Sci Food Agric, 2012, 92(4) : 862-869.
9.	Gonzalez EB. ACP journal club. Review: glucosamine (sulfate or hydrochloride) does not reduce pain in knee or hip osteoarthritis[J]. Ann Intern Med, 2013, 159(12) : JC8.
10.	Hanssen AD, Stuart MJ, Scott RD, et al. Surgical options for the middle-aged patient with osteoarthritis of the knee joint[J]. Instr Course Lect, 2001, 50: 499-511.
11.	朱秀英, 劉歆, 裴麗春, 等. 中老年婦女203例原發性骨質疏松癥與骨關節病患病情況分析[J]. 中國臨床康復, 2005, 9(39) : 136-137.
12.	吳波, 田衛群. 抗骨質疏松治療對治療膝骨性關節炎臨床療效的影響[J]. 中國中醫骨傷科雜志, 2013, 21(7) : 27-29.
13.	Cosman F, De Beur SJ, Leboff MS, et al. Clinician’s guide to prevention and treatment of osteoporosis[J]. Osteoporos Int, 2014, 25(10) : 2359-2381.
14.	馬厚勛. 老年骨質疏松癥治療策略[J]. 中華臨床醫師雜志: 電子版, 2013, 7(2) : 489-493.
15.	曾凱斌, 雷光華, 李康華. 骨質疏松癥與骨關節炎的相關性研究進展[J]. 中國骨質疏松雜志, 2007, 13(1) : 63-68.
16.	張弛, 葉斌, 張海林, 等. 抗骨質疏松治療對老年性膝關節骨關節炎療效的影響[J]. 實用老年醫學, 2011, 25(4) : 346-347.
17.	Mansfield K, Teixeira CC, Adams CS, et al. Phosphate ions mediate chondrocyte apoptosis through a plasma membrane transporter mechanism[J]. Bone, 2001, 28(1) : 1-8.

1. Lingard EA, Mitchell SY, Francis RM, et al. The prevalence of osteoporosis in patients with severe hip and knee osteoarthritis awaiting joint arthroplasty[J]. Age Ageing, 2010, 39(2) : 234-239.
2. 陳鴻儒. 玻璃酸鈉注射液治療膝關節骨關節炎療效觀察[J]. 現代中西醫結合雜志, 2011, 20(4) : 449-450.
3. 曹小燕, 李鳳霞, 葉青. 唑來膦酸鈉抗骨質疏松治療膝骨關節炎的療效觀察[J]. 湖北醫藥學院學報, 2014, 33(1) : 56-58.
4. Lequesne M. Indices of severity and disease activity for osteoarthritis[J]. Semin Arthritis Rheum, 1991, 20(6, Suppl 2) : 48-54.
5. 余素君, 納世麗, 魏薇, 等. 鹽酸氨基葡萄糖聯合非甾體抗炎藥治療中度膝關節骨關節炎的臨床研究[J]. 現代生物醫學進展, 2015, 15(10) : 1919-1922.
6. 郭世紱. 性激素和細胞因子與骨關節炎及骨質疏松的關系[J]. 國外醫學: 內分泌學分冊, 2003, 23(2) : 98-100.
7. 施桂英. 關節炎概要[M]. 北京: 中國醫藥科技出版社, 2000: 432-433.
8. Kanzaki N, Saito K, Maeda A, et al. Effect of a dietary supplement containing glucosamine hydrochloride, chondroitin sulfate and quercetin glycosides on symptomatic knee osteoarthritis: a randomized, double-blind, placebo-controlled study[J]. J Sci Food Agric, 2012, 92(4) : 862-869.
9. Gonzalez EB. ACP journal club. Review: glucosamine (sulfate or hydrochloride) does not reduce pain in knee or hip osteoarthritis[J]. Ann Intern Med, 2013, 159(12) : JC8.
10. Hanssen AD, Stuart MJ, Scott RD, et al. Surgical options for the middle-aged patient with osteoarthritis of the knee joint[J]. Instr Course Lect, 2001, 50: 499-511.
11. 朱秀英, 劉歆, 裴麗春, 等. 中老年婦女203例原發性骨質疏松癥與骨關節病患病情況分析[J]. 中國臨床康復, 2005, 9(39) : 136-137.
12. 吳波, 田衛群. 抗骨質疏松治療對治療膝骨性關節炎臨床療效的影響[J]. 中國中醫骨傷科雜志, 2013, 21(7) : 27-29.
13. Cosman F, De Beur SJ, Leboff MS, et al. Clinician’s guide to prevention and treatment of osteoporosis[J]. Osteoporos Int, 2014, 25(10) : 2359-2381.
14. 馬厚勛. 老年骨質疏松癥治療策略[J]. 中華臨床醫師雜志: 電子版, 2013, 7(2) : 489-493.
15. 曾凱斌, 雷光華, 李康華. 骨質疏松癥與骨關節炎的相關性研究進展[J]. 中國骨質疏松雜志, 2007, 13(1) : 63-68.
16. 張弛, 葉斌, 張海林, 等. 抗骨質疏松治療對老年性膝關節骨關節炎療效的影響[J]. 實用老年醫學, 2011, 25(4) : 346-347.
17. Mansfield K, Teixeira CC, Adams CS, et al. Phosphate ions mediate chondrocyte apoptosis through a plasma membrane transporter mechanism[J]. Bone, 2001, 28(1) : 1-8.

West China Medical Journal

Observation on the Effect of Glucosamine Hydrochloride Combined with Antiosteoporosis Drugs in the Treatment of Senile Knee Osteoarthritis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content