腋窩逆行淋巴顯影在乳腺癌手術中的應用_West China Medical Journal

Authors：

 陳潔 ¹ , 王竹 ² ,  呂青 ¹ , 杜正貴 ¹ , 譚秋文 ¹ , 王強 ² , 曾荷 ¹

1. ;
2. ;

Corresponding?author：

呂青, Email: lqlq1963@163.com

Keywords：

乳腺癌; 腋窩逆行淋巴顯影; 上肢淋巴水腫

DOI：

10.7507/1002-0179.201600396

Video：

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Abstract Full text Figures/Tables Video References Cited by

同側上肢的淋巴水腫是乳腺癌腋窩處理后一種常見的，同時也是治療非常困難的并發癥。近年來新發明的腋窩逆行淋巴顯影（ARM）技術能通過示蹤劑顯示引流同側上肢的淋巴管及淋巴結，從而避免在行腋窩淋巴結清掃或腋窩的前哨淋巴結活體組織檢查時傷及這些結構，以達到降低術后上肢淋巴水腫發生概率的目的。現有的文獻資料顯示，ARM在乳腺癌腋窩手術中是可行的，且ARM后保護腋窩逆行淋巴顯影顯示的淋巴結及其淋巴管的確能降低術后同側上肢的淋巴水腫發生率。

Citation： 陳潔, 王竹, 呂青, 杜正貴, 譚秋文, 王強, 曾荷. 腋窩逆行淋巴顯影在乳腺癌手術中的應用. West China Medical Journal, 2016, 31(8): 1458-1462. doi: 10.7507/1002-0179.201600396 Copy

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2.	朱倩男, 夏添松, 王水.逆行腋窩淋巴示蹤技術預防乳腺癌術后上肢淋巴水腫[J].江蘇醫藥, 2015, 41(1):78-80.
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7.	Schijven MP, Vingerhoets AJ, Rutten HJ, et al. Comparison of morbidity between axillary lymph node dissection and sentinel node biopsy[J]. Eur J Surg Oncol, 2003, 29(4):341-350.
8.	Ashikaga T, Krag DN, Land SR, et al. Morbidity results from the NSABP B-32 trial comparing sentinel lymph node dissection versus axillary dissection[J]. J Surg Oncol, 2010, 102(2):111-118.
9.	Wilke LG, McCall LM, Posther KE, et al. Surgical complications associated with sentinel lymph node biopsy:results from a prospective international cooperative group trial[J]. Ann Surg Oncol, 2006, 13(4):491-500.
10.	Rockson SG, Rivera KK. Estimating the population burden of lymphedema[J]. Ann N Y Acad Sci, 2008, 1131:147-154.
11.	Shaw C, Mortimer P, Judd PA. Randomized controlled trial comparing a low-fat diet with a weight-reduction diet in breast cancer-related lymphedema[J]. Cancer, 2007, 109(10):1949-1956.
12.	Petrek JA, Senie RT, Peters M, et al. Lymphedema in a cohort of breast carcinoma survivors 20 years after diagnosis[J]. Cancer, 2001, 92(6):1368-1377.
13.	Thompson M, Korourian S, Henry-Tillman R, et al. Axillary reverse mapping (ARM):a new concept to identify and enhance lymphatic preservation[J]. Ann Surg Oncol, 2007, 14(6):1890-1895.
14.	Nos C, Lesieur B, Clough KB, et al. Blue dye injection in the arm in order to conserve the lymphatic drainage of the arm in breast cancer patients requiring an axillary dissection[J]. Ann Surg Oncol, 2007, 14(9):2490-2496.
15.	Boneti C, Korourian S, Bland K, et al. Axillary reverse mapping:mapping and preserving arm lymphatics may be important in preventing lymphedema during sentinel lymph node biopsy[J]. J Am Coll Surg, 2008, 206(5):1038-1044.
16.	Ikeda K, Ogawa Y, Komatsu H, et al. Evaluation of the metastatic status of lymph nodes identified using axillary reverse mapping in breast cancer patients[J]. World J Surg Oncol, 2012(10):233-239.
17.	Clough KB, Nasr R, Nos C, et al. New anatomical classification of the axilla with implications for sentinel node biopsy[J]. Br J Surg, 2010, 97(11):1659-1665.
18.	Ponzone R, Mininanni P, Cassina E, et al. Axillary reverse mapping in breast cancer:can we spare what we find?[J]. Ann Surg Oncol, 2008, 15(1):390-391.
19.	Casabona F, Bogliolo S, Valenzano Menada M, et al. Feasibility of axillary reverse mapping during sentinel lymph node biopsy in breast cancer patients[J]. Ann Surg Oncol, 2009, 16(9):2459-2463.
20.	Connor C, McGinness M, Mammen J, et al. Axillary reverse mapping:a prospective study in women with clinically node negative and node positive breast cancer[J]. Ann Surg Oncol, 2013, 20(10):3303-3307.
21.	Ochoa D, Korourian S, Boneti C, et al. Axillary reverse mapping:five-year experience[J]. Surgery, 2014, 156(5):1261-1268.
22.	Beek MA, Gobardhan PD, Klompenhouwer EG, et al. Axillary reverse mapping (ARM) in clinically node positive breast cancer patients[J]. Eur J Surg Oncol, 2015, 41(1):59-63.
23.	Fiorito S, Serafino A, Andreola F, et al. Toxicity and biocompatibility of carbon nanoparticles[J]. J Nano Sci Nanotechnol, 2006, 6(3):591-599.
24.	謝錫駒, 黃村榕, 鄭偉, 等.上肢淋巴定位顯影在乳腺癌ALND術中的應用價值[J].實用臨床醫藥雜志, 2014, 18(24):43-45.
25.	陶慶松, 張亞, 杲圣, 等.腋窩逆行淋巴顯影聯合術中細針穿刺活檢預防腋窩淋巴清掃術后上肢淋巴水腫[J].南京醫科大學學報, 2015, 35(2):211-213.
26.	Nos C, Kaufmann G, Clough KB, et al. Combined axillary reverse mapping (ARM) technique for breast cancer patients requiring axillary dissection[J]. Ann Surg Oncol, 2008, 15(9):2550-2555.
27.	Britton TB, Chandra CK, Pinder SE, et al. Lymphatic drainage pathways of the breast and the upper limb[J]. Nucl Med Commun, 2009, 30(6):427-430.
28.	Samorani D, Fogacci T, Panzini I, et al. The use of indocyanine green to detect sentinel nodes in breast cancer:a prospective study[J]. Eur J Surg Oncol, 2015, 41(1):60-70.
29.	Noguchi M, Yokoi M, Nakano Y. Axillary reverse mapping with indocyanine fluorescence imaging in patients with breast cancer[J]. J Surg Oncol, 2010, 101(3):217-221.
30.	Noguchi M, Noguchi M, Nakano Y, et al. Axillary reverse mapping using fluorescence imaging system in breast cancer[J]. J Surg Oncol, 2012, 105(3):229-234.
31.	Sakurai T, Endo M, Shimizu K, et al. Axillary reverse mapping using fluorescence imaging is useful for identifying the risk group of postoperative lymphedema in breast cancer patients undergoing sentinel node biopsies[J]. J Surg Oncol, 2014, 109(6):612-615.
32.	Noguchi M, Miura S, Morioka E, et al. Is axillary reverse mapping feasible in breast cancer patients?[J]. Eur J Sueg Oncol, 2015, 41(4):442-449.

1. 吳祥德, 董守義.乳腺疾病診治[M]. 2版.北京:人民衛生出版社, 2008:176-179.
2. 朱倩男, 夏添松, 王水.逆行腋窩淋巴示蹤技術預防乳腺癌術后上肢淋巴水腫[J].江蘇醫藥, 2015, 41(1):78-80.
3. Mansel RE, Fallowfield L, Kissin M, et al. Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer:the ALMANAC Trial[J]. J Natl Cancer Inst, 2006, 98(9):599-609.
4. Leidenius M, Leivonen M, Vironen J, et al. The consequences of long-time arm morbidity in node-negative breast cancer patients with sentinel node biopsy or axillary clearance[J]. J Surg Oncol, 2005, 92(1):23-31.
5. Ronka R, von Smitten K, Tasmuth T, et al. One-year morbidity after sentinel node biopsy and breast surgery[J]. Breast, 2005, 14(1):28-36.
6. Blanchard DK, Donohue JH, Reynolds C, et al. Relapse and morbidity in patients undergoing sentinel lymph node biopsy alone or with axillary dissection for breast cancer[J]. Archives, 2003, 138(5):482-487.
7. Schijven MP, Vingerhoets AJ, Rutten HJ, et al. Comparison of morbidity between axillary lymph node dissection and sentinel node biopsy[J]. Eur J Surg Oncol, 2003, 29(4):341-350.
8. Ashikaga T, Krag DN, Land SR, et al. Morbidity results from the NSABP B-32 trial comparing sentinel lymph node dissection versus axillary dissection[J]. J Surg Oncol, 2010, 102(2):111-118.
9. Wilke LG, McCall LM, Posther KE, et al. Surgical complications associated with sentinel lymph node biopsy:results from a prospective international cooperative group trial[J]. Ann Surg Oncol, 2006, 13(4):491-500.
10. Rockson SG, Rivera KK. Estimating the population burden of lymphedema[J]. Ann N Y Acad Sci, 2008, 1131:147-154.
11. Shaw C, Mortimer P, Judd PA. Randomized controlled trial comparing a low-fat diet with a weight-reduction diet in breast cancer-related lymphedema[J]. Cancer, 2007, 109(10):1949-1956.
12. Petrek JA, Senie RT, Peters M, et al. Lymphedema in a cohort of breast carcinoma survivors 20 years after diagnosis[J]. Cancer, 2001, 92(6):1368-1377.
13. Thompson M, Korourian S, Henry-Tillman R, et al. Axillary reverse mapping (ARM):a new concept to identify and enhance lymphatic preservation[J]. Ann Surg Oncol, 2007, 14(6):1890-1895.
14. Nos C, Lesieur B, Clough KB, et al. Blue dye injection in the arm in order to conserve the lymphatic drainage of the arm in breast cancer patients requiring an axillary dissection[J]. Ann Surg Oncol, 2007, 14(9):2490-2496.
15. Boneti C, Korourian S, Bland K, et al. Axillary reverse mapping:mapping and preserving arm lymphatics may be important in preventing lymphedema during sentinel lymph node biopsy[J]. J Am Coll Surg, 2008, 206(5):1038-1044.
16. Ikeda K, Ogawa Y, Komatsu H, et al. Evaluation of the metastatic status of lymph nodes identified using axillary reverse mapping in breast cancer patients[J]. World J Surg Oncol, 2012(10):233-239.
17. Clough KB, Nasr R, Nos C, et al. New anatomical classification of the axilla with implications for sentinel node biopsy[J]. Br J Surg, 2010, 97(11):1659-1665.
18. Ponzone R, Mininanni P, Cassina E, et al. Axillary reverse mapping in breast cancer:can we spare what we find?[J]. Ann Surg Oncol, 2008, 15(1):390-391.
19. Casabona F, Bogliolo S, Valenzano Menada M, et al. Feasibility of axillary reverse mapping during sentinel lymph node biopsy in breast cancer patients[J]. Ann Surg Oncol, 2009, 16(9):2459-2463.
20. Connor C, McGinness M, Mammen J, et al. Axillary reverse mapping:a prospective study in women with clinically node negative and node positive breast cancer[J]. Ann Surg Oncol, 2013, 20(10):3303-3307.
21. Ochoa D, Korourian S, Boneti C, et al. Axillary reverse mapping:five-year experience[J]. Surgery, 2014, 156(5):1261-1268.
22. Beek MA, Gobardhan PD, Klompenhouwer EG, et al. Axillary reverse mapping (ARM) in clinically node positive breast cancer patients[J]. Eur J Surg Oncol, 2015, 41(1):59-63.
23. Fiorito S, Serafino A, Andreola F, et al. Toxicity and biocompatibility of carbon nanoparticles[J]. J Nano Sci Nanotechnol, 2006, 6(3):591-599.
24. 謝錫駒, 黃村榕, 鄭偉, 等.上肢淋巴定位顯影在乳腺癌ALND術中的應用價值[J].實用臨床醫藥雜志, 2014, 18(24):43-45.
25. 陶慶松, 張亞, 杲圣, 等.腋窩逆行淋巴顯影聯合術中細針穿刺活檢預防腋窩淋巴清掃術后上肢淋巴水腫[J].南京醫科大學學報, 2015, 35(2):211-213.
26. Nos C, Kaufmann G, Clough KB, et al. Combined axillary reverse mapping (ARM) technique for breast cancer patients requiring axillary dissection[J]. Ann Surg Oncol, 2008, 15(9):2550-2555.
27. Britton TB, Chandra CK, Pinder SE, et al. Lymphatic drainage pathways of the breast and the upper limb[J]. Nucl Med Commun, 2009, 30(6):427-430.
28. Samorani D, Fogacci T, Panzini I, et al. The use of indocyanine green to detect sentinel nodes in breast cancer:a prospective study[J]. Eur J Surg Oncol, 2015, 41(1):60-70.
29. Noguchi M, Yokoi M, Nakano Y. Axillary reverse mapping with indocyanine fluorescence imaging in patients with breast cancer[J]. J Surg Oncol, 2010, 101(3):217-221.
30. Noguchi M, Noguchi M, Nakano Y, et al. Axillary reverse mapping using fluorescence imaging system in breast cancer[J]. J Surg Oncol, 2012, 105(3):229-234.
31. Sakurai T, Endo M, Shimizu K, et al. Axillary reverse mapping using fluorescence imaging is useful for identifying the risk group of postoperative lymphedema in breast cancer patients undergoing sentinel node biopsies[J]. J Surg Oncol, 2014, 109(6):612-615.
32. Noguchi M, Miura S, Morioka E, et al. Is axillary reverse mapping feasible in breast cancer patients?[J]. Eur J Sueg Oncol, 2015, 41(4):442-449.

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腋窩逆行淋巴顯影在乳腺癌手術中的應用

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