Advances of autophagy in erectile dysfunction_West China Medical Journal

Authors：

WU Changjing ¹ , FU Fudong ¹ ,  YUAN Jiuhong ^1,2

1. Andrology Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Department of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

YUAN Jiuhong, Email: jiuhongyuan2107@163.com

Keywords：

Autophagy; Erectile dysfunction; Hypoxia; Diabetes mellitus; Aging

DOI：

10.7507/1002-0179.201902072

Video：

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Abstract Full text Figures/Tables Video References Cited by

Autophagy is a lysosome dependent, conservative material degradation process, which exists in all eukaryotic cells and plays import roles in many pathophysiology process. Erectile dysfunction (ED) is a common male disease with multiple etiology. In recent years, more and more evidences have demonstrated that autophagy has a close relation to ED, therefore, we combine previous study to classify ED by hypoxia, aging, diabetes and other causes, and review the advances of autophagy in ED.

Citation： WU Changjing, FU Fudong, YUAN Jiuhong. Advances of autophagy in erectile dysfunction. West China Medical Journal, 2019, 34(4): 433-436. doi: 10.7507/1002-0179.201902072 Copy

1.	Deng Z, Purtell K, Lachance V, et al. Autophagy receptors and neurodegenrative disease. Trends Cell Biol, 2017, 27(7): 491-504.
2.	Kuma A, Komatsu M, Mizushima N. Autophagy-monitoring and autophagy-deficient mice. Autophagy, 2017, 13(10): 1619-1628.
3.	Harnett MM, Pineda MA, de Late PL, et al. From Christian de Duve to yoshinori ohsumi: more to autophagy than just dining at home. Biomed J, 2017, 40(1): 9-22.
4.	Dlugoska H. Autophagy as a universal intracellular process. A comment on the 2016 Nobel prize in physiology or medicine. Ann Parasitol, 2017, 63(3): 153-157.
5.	Hurley JH, Young LN. Mechanisms of autophagy initiation. Annu Rev Biochem, 2017, 86: 225-244.
6.	Zachari M, Ganley IG. The mammalian ULK1 complex and autophagy initiation. Essays Biochem, 2017, 61(6): 585-596.
7.	Mizushima N, Levine B, Cuervo AM, et al. Autophagy fights disease through cellular self-digestion. Nature, 2008, 451(7182): 1069-1075.
8.	Hubbi ME, Semenza GL. An essential role for chaperone-mediated autophagy in cell cycle progession. Autophagy, 2015, 11(5): 850-851.
9.	Cudjoe J, Saleh T, Hawkridge AM. Proteomics insights into autophagy. Proteomics, 2017, 17(20): 1-17.
10.	Ohsumi Y. Historical landmarks of autophagy research. Cell Res, 2014, 24(1, SI): 9-23.
11.	Kim J, Kundu M, Viollet B, et al. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol, 2011, 13(2): 132-141.
12.	Kim J, Kim YC, Fang C, et al. Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell, 2013, 152(1/2): 290-303.
13.	Egan DF, Shackelford DB, Mihaylova MM, et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science, 2011, 331(616): 456-461.
14.	Rew KT, Heidelbaugh JJ. Erectile dysfunction. Am Fam Physician, 2016, 94(10): 820-827.
15.	Semenza GL. Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Trends Pharmacol Sci, 2012, 33(4): 207-214.
16.	鄧吉坤, 譚艷. 缺氧條件下自噬導致CCSMC表型轉化機制的研究進展. 中華男科學雜志, 2016, 22(11): 1025-1029.
17.	Zhang HY, Kong XX, Kang JS, et al. Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells. Toxicol Sci, 2009, 110(2): 376-388.
18.	Yang F, Zhao JF, Shou QY, et al. Phenotypic modulation of corpus cavernosum smooth muscle cells in a rat model of cavernous neurectomy. PLoS One, 2014, 9(8): 1-6.
19.	趙凡, 葉秒勇, 趙劍鋒, 等. 陰莖海綿體平滑肌細胞表型轉化和勃起功能障礙的相關研究進展. 中華男科學雜志, 2018, 24(10): 927-932.
20.	Luo S, Garcia-Arencibia M, Zhao R, et al. Bim inhibits autophagy by recruiting Beclin 1 to microtubules. Mol Cell, 2012, 47(3): 359-370.
21.	Zhang J, Wu XJ, Zhuo DX, et al. Effect of tankyrase 1 on autophagy in the corpus cavernosum smooth muscle cells from ageing rats with erectile dysfunction and its potential mechanism. Asian J Androl, 2010, 12(5): 744-752.
22.	Tang Z, Cui K, Luan Y, et al. Human tissue kallikrein 1 ameliorates erectile function via modulation of macroautophagy in aged transgenic rats. Andrology, 2018, 6(5): 766-774.
23.	王濤, 劉繼紅. 勃起功能障礙病因學研究進展. 醫學研究生學報, 2005, 18(2): 153-155, 160.
24.	Wang XM, Song SS, Xiao H, et al. Fibroblast growth factor 21 protects against high glucose induced cellular damage and dysfunction of endothelial nitric-oxide synthase in endothelial cells. Cell Physiol Biochem, 2014, 34(3): 658-671.
25.	Jimenez SM, Menzies FM, Chang YY, et al. The hedgehog signaling pathway regulates autophagy. Nat Commum, 2012, 3(1200): 1-11.
26.	Lin H, Wang T, Ruan Y, et al. Rapamycin supplementation may ameliorate erectile function in rats with streptozotocin-induced type 1 diabets by inducing autophagy and inhibiting apoptosis, endothelial dysfunction and corporal fibrosis. J Sex Med, 2018, 15(9): 1246-1259.
27.	Zhu GQ, Jeon SH, Bae WJ, et al. Efficent promotion of autophagy and angiogenesis using mesenchymal stem cell therapy enhanced by the low-energy shock waves in the treatment of erectile dysfunction. Stem Cells Int, 2018, 2018: 1302672.
28.	Zhang J, Li AM, Liu BX, et al. Effect of icarisid Ⅱon diabet rats with erectile dysfunction and its potential mechanism via assessment of AGEs, autophagy, mTOR and the NO-cGMP pathway. Asian J Androl, 2013, 15(1): 143-148.
29.	Palese MA, Crone JK, Burnett AL. A castrated mouse model of erectile dysfunction. J Androl, 2003, 24(5): 699-703.
30.	Wang XJ, Xu TY, Xia LL, et al. Castration impairs erectile organ structure and function by inhibiting autophagy and promoting apoptosis of corpus cavernosum smooth muscle cells in rats. Int Urol Nephrol, 2015, 47(7): 1105-1115.

1. Deng Z, Purtell K, Lachance V, et al. Autophagy receptors and neurodegenrative disease. Trends Cell Biol, 2017, 27(7): 491-504.
2. Kuma A, Komatsu M, Mizushima N. Autophagy-monitoring and autophagy-deficient mice. Autophagy, 2017, 13(10): 1619-1628.
3. Harnett MM, Pineda MA, de Late PL, et al. From Christian de Duve to yoshinori ohsumi: more to autophagy than just dining at home. Biomed J, 2017, 40(1): 9-22.
4. Dlugoska H. Autophagy as a universal intracellular process. A comment on the 2016 Nobel prize in physiology or medicine. Ann Parasitol, 2017, 63(3): 153-157.
5. Hurley JH, Young LN. Mechanisms of autophagy initiation. Annu Rev Biochem, 2017, 86: 225-244.
6. Zachari M, Ganley IG. The mammalian ULK1 complex and autophagy initiation. Essays Biochem, 2017, 61(6): 585-596.
7. Mizushima N, Levine B, Cuervo AM, et al. Autophagy fights disease through cellular self-digestion. Nature, 2008, 451(7182): 1069-1075.
8. Hubbi ME, Semenza GL. An essential role for chaperone-mediated autophagy in cell cycle progession. Autophagy, 2015, 11(5): 850-851.
9. Cudjoe J, Saleh T, Hawkridge AM. Proteomics insights into autophagy. Proteomics, 2017, 17(20): 1-17.
10. Ohsumi Y. Historical landmarks of autophagy research. Cell Res, 2014, 24(1, SI): 9-23.
11. Kim J, Kundu M, Viollet B, et al. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol, 2011, 13(2): 132-141.
12. Kim J, Kim YC, Fang C, et al. Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell, 2013, 152(1/2): 290-303.
13. Egan DF, Shackelford DB, Mihaylova MM, et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science, 2011, 331(616): 456-461.
14. Rew KT, Heidelbaugh JJ. Erectile dysfunction. Am Fam Physician, 2016, 94(10): 820-827.
15. Semenza GL. Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Trends Pharmacol Sci, 2012, 33(4): 207-214.
16. 鄧吉坤, 譚艷. 缺氧條件下自噬導致CCSMC表型轉化機制的研究進展. 中華男科學雜志, 2016, 22(11): 1025-1029.
17. Zhang HY, Kong XX, Kang JS, et al. Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells. Toxicol Sci, 2009, 110(2): 376-388.
18. Yang F, Zhao JF, Shou QY, et al. Phenotypic modulation of corpus cavernosum smooth muscle cells in a rat model of cavernous neurectomy. PLoS One, 2014, 9(8): 1-6.
19. 趙凡, 葉秒勇, 趙劍鋒, 等. 陰莖海綿體平滑肌細胞表型轉化和勃起功能障礙的相關研究進展. 中華男科學雜志, 2018, 24(10): 927-932.
20. Luo S, Garcia-Arencibia M, Zhao R, et al. Bim inhibits autophagy by recruiting Beclin 1 to microtubules. Mol Cell, 2012, 47(3): 359-370.
21. Zhang J, Wu XJ, Zhuo DX, et al. Effect of tankyrase 1 on autophagy in the corpus cavernosum smooth muscle cells from ageing rats with erectile dysfunction and its potential mechanism. Asian J Androl, 2010, 12(5): 744-752.
22. Tang Z, Cui K, Luan Y, et al. Human tissue kallikrein 1 ameliorates erectile function via modulation of macroautophagy in aged transgenic rats. Andrology, 2018, 6(5): 766-774.
23. 王濤, 劉繼紅. 勃起功能障礙病因學研究進展. 醫學研究生學報, 2005, 18(2): 153-155, 160.
24. Wang XM, Song SS, Xiao H, et al. Fibroblast growth factor 21 protects against high glucose induced cellular damage and dysfunction of endothelial nitric-oxide synthase in endothelial cells. Cell Physiol Biochem, 2014, 34(3): 658-671.
25. Jimenez SM, Menzies FM, Chang YY, et al. The hedgehog signaling pathway regulates autophagy. Nat Commum, 2012, 3(1200): 1-11.
26. Lin H, Wang T, Ruan Y, et al. Rapamycin supplementation may ameliorate erectile function in rats with streptozotocin-induced type 1 diabets by inducing autophagy and inhibiting apoptosis, endothelial dysfunction and corporal fibrosis. J Sex Med, 2018, 15(9): 1246-1259.
27. Zhu GQ, Jeon SH, Bae WJ, et al. Efficent promotion of autophagy and angiogenesis using mesenchymal stem cell therapy enhanced by the low-energy shock waves in the treatment of erectile dysfunction. Stem Cells Int, 2018, 2018: 1302672.
28. Zhang J, Li AM, Liu BX, et al. Effect of icarisid Ⅱon diabet rats with erectile dysfunction and its potential mechanism via assessment of AGEs, autophagy, mTOR and the NO-cGMP pathway. Asian J Androl, 2013, 15(1): 143-148.
29. Palese MA, Crone JK, Burnett AL. A castrated mouse model of erectile dysfunction. J Androl, 2003, 24(5): 699-703.
30. Wang XJ, Xu TY, Xia LL, et al. Castration impairs erectile organ structure and function by inhibiting autophagy and promoting apoptosis of corpus cavernosum smooth muscle cells in rats. Int Urol Nephrol, 2015, 47(7): 1105-1115.

West China Medical Journal

Advances of autophagy in erectile dysfunction

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