Changes of Plasma Platelet Activating Factor,Interleukin-8 and Interferon-γ after Surgery with Extracorporeal Circulation and Their Clinical Significance_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

XIADao-kui ,  LIUYun , HUXu

Department of Cardiothoracic Surgery, Yichang Central People's Hospital, the First College of Clinical Medicine, China Three Gorges University, Yichang 443003, Hubei, P. R. China;

Corresponding?author：

LIUYun, Email: ly.1982_818@163.com

Keywords：

Extracorporeal circulation; Acute lung injury/acute respiratory distress syndrome; Platelet activating factor; Interleukin-8; Interferon-γ

DOI：

10.7507/1007-4848.20140062

Video：

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Objective To investigate the changes of plasma platelet activating factor (PAF) interleukin-8(IL-8) and interferon-γ (IFN-γ) in patients after surgery with extracorporeal circulation (ECC) and their clinical significance. Methods Seventy-five patients undergoing surgery with ECC in the First College of Clinical Medicine,China Three Gorges University from June 2012 to June 2013 were enrolled in this study. According to the presence of postoperative acute lung injury/acute respiratory distress syndrome (ALI/ARDS) all the 75 patients were divided into 2 groups. In ALI/ARDS group, there were 28 patients including 20 male and 8 female patients with their age of 53.6±8.2 years. In the control group,there were 47 patients without postoperative ALI/ARDS,including 32 male and 15 female patients with their age of 56.9±11.8 years. Dynamic variations of plasma PAF,IL-8 and IFN-γ of these patients were examined with enzyme-linked immunosorbent assay (ELISA) and compared between the 2 groups. Results In ALI/ARDS group,plasma IL-8 and IFN-γ reached peak levels at 48 hours after surgery and gradually decreased after that;plasma PAF reached the peak level at 96 hours after surgery and gradually decreased after that. Postoperative plasma PAF (96 hours after surgery:16 029.5±4 203.7 mU/ml vs. 4 520.1±312.2 mU/ml,P<0.05) IL-8 (48 hours after surgery:48 580.5±8 095.8 pg/ml vs. 5 990.5±1 179.0 pg/ml,P<0.05) and IFN-γ (48 hours after surgery:258.5±76.1 pg/ml vs. 26.1±11.5 pg/ml,P<0.05) of ALI/ARDS group were significantly higher than those of the control group at 48 hours,96 hours and 144 hours after surgery. Conclusion Plasma PAF,IL-8 and IFN-γ change significantly after surgery with ECC,which may play an important role in the pathogenesis of postoperative ALI/ARDS.

Citation： XIADao-kui, LIUYun, HUXu. Changes of Plasma Platelet Activating Factor,Interleukin-8 and Interferon-γ after Surgery with Extracorporeal Circulation and Their Clinical Significance. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2014, 21(2): 212-215. doi: 10.7507/1007-4848.20140062 Copy

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3.	中華醫學會呼吸病學分會.急性肺損傷/急性呼吸窘迫綜合征的診斷標準 (草案).中華結核和呼吸雜志,2007,16 (4):343-349.
4.	林慧慶,黃杰,毛志福.先天性心臟病體外循環心內直視手術死亡率的相關因素分析.臨床外科雜志,2003,11 (5):340-340.
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6.	劉偉,金發光.急性肺損傷/急性呼吸窘迫綜合征的治療新進展.中華肺部疾病雜志,2013,6 (1):61-63.
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10.	賈雪梅,楊光福.急性肺損傷/急性呼吸窘迫綜合征發病機制的研究進展.中國實用醫藥,2011,6 (32):242-244.
11.	Hart SP,Dransfield I,Rossi AG.Phagocytosis of apoptotic cells.Methods,2008,44 (3):280-285.
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13.	Meng HY,Sun Y,Lu J,et al.Exogenous surfactant May improve oxygenation but not mortality in adult patients with acute lung injury/acute respiratory distress syndrome:a meta-analysis of 9 clinical trials.J Cardiothorac Vasc Anesth,2012,26 (5):849-856.
14.	常亞麗,郭農建.血小板活化因子參與血小板-中性粒細胞活化的研究.醫學綜述,2007,13 (21):1612-1614.
15.	Lee YM,Hybertson BM,Cho HG,et al.Platelet-activating factor induces lung inflammation and leak in rats:Hydrogen peroxide production along neutrophil-lung endothelial cell interfaces.J Lab Clin Med,2002,140 (5):312-319.
16.	Bulger EM,Arbabi S,Garcia I,et al.The macrophage response to endotoxin requires platelet activating factor.Shock,2002,17 (3):173-179.
17.	王剛,孫備,孟慶輝,等.血小板活化因子乙酰水解酶對大鼠重癥急性胰腺炎肺損傷的影響.中華實驗外科雜志,2006,23 (1):34-35.
18.	黃宏,周萍,劉友生,等.PAF拮抗劑BN50739對大鼠急性肺損傷的作用研究.第三軍醫大學學報,2002,24 (8):919-920.
19.	Lee JH,Jo YH,Kim K,et al.Effect of N-acetylcysteine (NAC) on acute lung injury and acute kidney injury in hemorrhagic shock.Resuscitation,2013,84 (1):121-127.
20.	Yubero S,Ramudo L,Manso MA,et al.Evaluation of N-acetylcysteine treatment in acute pancreatitis-induced lung injury.Inflamm Res,2012,61 (7):699-705.
21.	錢桂生.急性肺損傷和急性呼吸窘迫綜合征研究現狀與進展.解放軍醫學雜志,2009,34 (4):371-371.
22.	邰文琳,董昭興,張丹丹,等.骨髓間充質干細胞對脂多糖誘導的急性肺損傷小鼠的早期治療作用.南方醫科大學學報,2012,32 (3):283-290.
23.	Taccone P,Pesenti A,Latini R,et al.Prone positioning in patients with moderate and severe acute respiratory distress syndrome:a randomized controlled trial.JAMA,2009,302 (18):1977-1984.
24.	王茁,齊同謙,李鳴,等.胸部創傷患者免疫功能變化的臨床研究.世界今日醫學雜志,2002,3 (6):498-499.
25.	Babusyte A,Jeroch J,Stakauskas R,et al.The effect of induced sputum and bronchoalveolar lavage fluid from patients with chronic obstructive pulmonary disease on neutrophil migration in vitro.Medicina (Kaunas),2010,46 (5):315-322.
26.	Eickmeier O,Huebner M,Herrmann E,et al.Sputum biomarker profiles in cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) and association between pulmonary function.Cytokine,2010,50 (2):152-157.
27.	吳其夏,余應年,盧建.病理生理學.北京:中國協和醫科大學出版社,2003.341-347.
28.	董思遠,谷天祥,喻磊,等.依達拉奉對深低溫停循環肺的保護作用.中國胸心血管外科臨床雜志,2013,2 (2):192-197.

1. ?白春學.急性呼吸窘迫綜合征,危重醫學的重點.內科理論與實踐,2010,5 (6):453-454.
2. Lee JW,Fang XH,Gupta N,et al.Allogeneic human mesenchymal stem cells for treatment of E.coli endotoxin-induced acute lung injury in the ex vivo perfused human lung.Proc Natl Acad Sci U S A,2009,106 (38):16357-16362.
3. 中華醫學會呼吸病學分會.急性肺損傷/急性呼吸窘迫綜合征的診斷標準 (草案).中華結核和呼吸雜志,2007,16 (4):343-349.
4. 林慧慶,黃杰,毛志福.先天性心臟病體外循環心內直視手術死亡率的相關因素分析.臨床外科雜志,2003,11 (5):340-340.
5. 羅濱,張衛星,扶志敏,等.雙水平正壓通氣對急性肺損傷患者血氣及血流動力學指標的影響.中國胸心血管外科臨床雜志,2009,16 (6):454-458.
6. 劉偉,金發光.急性肺損傷/急性呼吸窘迫綜合征的治療新進展.中華肺部疾病雜志,2013,6 (1):61-63.
7. Dushianthan A,Grocott M,Postle AD,et al.Acute respiratory distress syndrome and acute lung injury.Postgrad Med J,2011,87 (1031):612-622.
8. Pierrakos C,Karanikolas M,Scolletta S,et al.Acute respiratory distress syndrome:pathophysiology and therapeutic options.J Clin Med Res,2012,4 (1):7-16.
9. Caironi P,Cressoni M,Chiumello D,et al.Lung opening and closing during ventilation of acute respiratory distress syndrome.Am J Respir Crit Care Med,2010,181 (6):578-586.
10. 賈雪梅,楊光福.急性肺損傷/急性呼吸窘迫綜合征發病機制的研究進展.中國實用醫藥,2011,6 (32):242-244.
11. Hart SP,Dransfield I,Rossi AG.Phagocytosis of apoptotic cells.Methods,2008,44 (3):280-285.
12. Briel M,Meade M,Mercat A,et al.Higher vs lower positive endexpiratory pressure in patients with acute lung injury and acute respiratory distress syndrome:systematic review and eta-analysis.JAMA,2010,303 (9):865-873.
13. Meng HY,Sun Y,Lu J,et al.Exogenous surfactant May improve oxygenation but not mortality in adult patients with acute lung injury/acute respiratory distress syndrome:a meta-analysis of 9 clinical trials.J Cardiothorac Vasc Anesth,2012,26 (5):849-856.
14. 常亞麗,郭農建.血小板活化因子參與血小板-中性粒細胞活化的研究.醫學綜述,2007,13 (21):1612-1614.
15. Lee YM,Hybertson BM,Cho HG,et al.Platelet-activating factor induces lung inflammation and leak in rats:Hydrogen peroxide production along neutrophil-lung endothelial cell interfaces.J Lab Clin Med,2002,140 (5):312-319.
16. Bulger EM,Arbabi S,Garcia I,et al.The macrophage response to endotoxin requires platelet activating factor.Shock,2002,17 (3):173-179.
17. 王剛,孫備,孟慶輝,等.血小板活化因子乙酰水解酶對大鼠重癥急性胰腺炎肺損傷的影響.中華實驗外科雜志,2006,23 (1):34-35.
18. 黃宏,周萍,劉友生,等.PAF拮抗劑BN50739對大鼠急性肺損傷的作用研究.第三軍醫大學學報,2002,24 (8):919-920.
19. Lee JH,Jo YH,Kim K,et al.Effect of N-acetylcysteine (NAC) on acute lung injury and acute kidney injury in hemorrhagic shock.Resuscitation,2013,84 (1):121-127.
20. Yubero S,Ramudo L,Manso MA,et al.Evaluation of N-acetylcysteine treatment in acute pancreatitis-induced lung injury.Inflamm Res,2012,61 (7):699-705.
21. 錢桂生.急性肺損傷和急性呼吸窘迫綜合征研究現狀與進展.解放軍醫學雜志,2009,34 (4):371-371.
22. 邰文琳,董昭興,張丹丹,等.骨髓間充質干細胞對脂多糖誘導的急性肺損傷小鼠的早期治療作用.南方醫科大學學報,2012,32 (3):283-290.
23. Taccone P,Pesenti A,Latini R,et al.Prone positioning in patients with moderate and severe acute respiratory distress syndrome:a randomized controlled trial.JAMA,2009,302 (18):1977-1984.
24. 王茁,齊同謙,李鳴,等.胸部創傷患者免疫功能變化的臨床研究.世界今日醫學雜志,2002,3 (6):498-499.
25. Babusyte A,Jeroch J,Stakauskas R,et al.The effect of induced sputum and bronchoalveolar lavage fluid from patients with chronic obstructive pulmonary disease on neutrophil migration in vitro.Medicina (Kaunas),2010,46 (5):315-322.
26. Eickmeier O,Huebner M,Herrmann E,et al.Sputum biomarker profiles in cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) and association between pulmonary function.Cytokine,2010,50 (2):152-157.
27. 吳其夏,余應年,盧建.病理生理學.北京:中國協和醫科大學出版社,2003.341-347.
28. 董思遠,谷天祥,喻磊,等.依達拉奉對深低溫停循環肺的保護作用.中國胸心血管外科臨床雜志,2013,2 (2):192-197.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Changes of Plasma Platelet Activating Factor,Interleukin-8 and Interferon-γ after Surgery with Extracorporeal Circulation and Their Clinical Significance

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