Dolichocolon with Colorectal Cancer: Report of 17 Cases and Review of The Literatures_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 周強 ^1,2 , 柴琛 ¹ ,  楊磊 ¹ , 李德榜 ¹

1. ;
2. ;

Corresponding?author：

楊磊, Email: yl41023@126.com

Keywords：

結腸冗長癥; 結直腸癌; 慢傳輸型便秘; 結腸黑變病

DOI：

10.7507/1007-9424.20140117

Video：

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目的總結結腸冗長癥合并結直腸癌的臨床病理特征，并文獻復習結腸冗長癥與結直腸癌的關系。方法回顧性分析蘭州大學第一醫院普外一科2011年1月至2012年12月期間收治的17例結腸冗長癥合并結直腸癌患者的臨床資料。結果 184例結直腸癌患者中合并結腸冗長癥17例（9.24%），合并家族性息肉病惡變2例（1.09%），合并遺傳性非息肉病性結直腸癌1例（0.54%），合并炎癥性腸病1例（0.54%）。合并結腸冗長癥的比例較高（P＜0.05）。其中術前經結腸氣鋇灌腸檢查診斷為結腸冗長癥5例，術中診斷為結腸冗長癥12例。所有患者均行手術治療，切除結腸13～80 cm，平均33.8 cm。術后發生肺部感染、切口液化1例，腹水1例，腸瘺1例，骶前感染1例。術后17例患者均獲隨訪，隨訪時間6～12個月，中位數為10個月。隨訪期間，1例患者于術后1年出現卵巢轉移。結論結腸冗長癥合并頑固性便秘可能是結直腸癌發病的高危因素。

Citation： 周強, 柴琛, 楊磊, 李德榜. Dolichocolon with Colorectal Cancer: Report of 17 Cases and Review of The Literatures. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(4): 485-487. doi: 10.7507/1007-9424.20140117 Copy

1.	鄭樹, 蔡善榮.中國大腸癌的病因學及人群防治研究[J].中華腫瘤雜志, 2004, 26(1):1-3.
2.	Jemal A, Bray F, Center MM, et al. Global cancer statistics[J]. CA Cancer J Clin, 2011, 61(2):69-90.
3.	郝捷, 趙平, 陳萬青. 2011中國腫瘤登記年報[M].北京:軍事醫學出版社, 2012:57-58.
4.	楊維良, 張新晨, 張好剛, 等.成人結腸冗長癥的診斷與外科治療82例報告[J].中華普通外科雜志, 2007, 22(12):905-908.
5.	Bharucha AE, Phillips SF. Slow transit constipation[J]. Gastroenterol Clin North Am, 2001, 30(1):77-95.
6.	丁義江, 哈楠林, 丁曙晴, 等.結腸慢傳輸型便秘與突觸素和P物質及血管活性腸肽的臨床研究[J].中華胃腸外科雜志, 2004, 7(6):485-487.
7.	Tomita R, Igarashi S, Fujisaki S, et al. The effects of neurotensin in the colon of patients with slow transit constipation[J]. Hepatogastroenterology, 2007, 54(78):1662-1666.
8.	童衛東.結腸慢傳輸型便秘的病因和診斷[J].醫學新知雜志, 2007, 17(1):1-2.
9.	譚麗, 譚至柔, 黃雪, 等.不同類型一氧化氮合酶在慢傳輸型便秘大鼠結腸中的表達[J].胃腸病學和肝病學雜志, 2011, 20(1):64-66.
10.	Lonkar P, Dedon PC. Reactive species and DNA damage in chronic inflammation:reconciling chemical mechanisms and biological fates[J]. Int J Cancer, 2011, 128(9):1999-2009.
11.	Gochman E, Mahajna J, Shenzer P, et al. The expression of iNOS and nitrotyrosine in colitis and colon cancer in humans[J]. Acta Histochem, 2012, 114(8):827-835.
12.	Zhu Y, Michelle Luo T, Jobin C, et al. Gut microbiota and probiotics in colon tumorigenesis[J]. Cancer Lett, 2011, 309(2):119-127.
13.	Sobhani I, Tap J, Roudot-Thoraval F, et al. Microbial dysbiosis in colorectal cancer (CRC) patients[J]. PLoS One, 2011, 6(1):e16393.
14.	Shen XJ, Rawls JF, Randall T, et al. Molecular characterization of mucosal adherent bacteria and associations with colorectal adenomas[J]. Gut Microbes, 2010, 1(3):138-147.
15.	Speare GS. Melanosis coli:experimental observations of its production and elimination in 23 cases[J]. Am J Surg, 1951, 82(5):631-637.
16.	Virchow R. Die pathologischen piganente[J]. Virchows Arch Patbol Anat, 1847, 1(2):379-486.
17.	Tikkanen L, Matsushima T, Natori S. Mutagenicity of anthraquinones in the Salmonella preincubation test[J]. Mutat Res, 1983, 116(3-4):297-304.
18.	Westendorf J, Marquardt H, Poginsky B, et al. Genotoxi-city of naturally occurring hydroxyanthraquinones[J]. Murat Res, 1990, 240(1):1-12.
19.	子樹明, 崔龍, 楊明.結腸黑變病與結腸直腸息肉、結腸直腸癌的關系[J].外科理論與實踐, 2010, 15(2):188-190.

1. 鄭樹, 蔡善榮.中國大腸癌的病因學及人群防治研究[J].中華腫瘤雜志, 2004, 26(1):1-3.
2. Jemal A, Bray F, Center MM, et al. Global cancer statistics[J]. CA Cancer J Clin, 2011, 61(2):69-90.
3. 郝捷, 趙平, 陳萬青. 2011中國腫瘤登記年報[M].北京:軍事醫學出版社, 2012:57-58.
4. 楊維良, 張新晨, 張好剛, 等.成人結腸冗長癥的診斷與外科治療82例報告[J].中華普通外科雜志, 2007, 22(12):905-908.
5. Bharucha AE, Phillips SF. Slow transit constipation[J]. Gastroenterol Clin North Am, 2001, 30(1):77-95.
6. 丁義江, 哈楠林, 丁曙晴, 等.結腸慢傳輸型便秘與突觸素和P物質及血管活性腸肽的臨床研究[J].中華胃腸外科雜志, 2004, 7(6):485-487.
7. Tomita R, Igarashi S, Fujisaki S, et al. The effects of neurotensin in the colon of patients with slow transit constipation[J]. Hepatogastroenterology, 2007, 54(78):1662-1666.
8. 童衛東.結腸慢傳輸型便秘的病因和診斷[J].醫學新知雜志, 2007, 17(1):1-2.
9. 譚麗, 譚至柔, 黃雪, 等.不同類型一氧化氮合酶在慢傳輸型便秘大鼠結腸中的表達[J].胃腸病學和肝病學雜志, 2011, 20(1):64-66.
10. Lonkar P, Dedon PC. Reactive species and DNA damage in chronic inflammation:reconciling chemical mechanisms and biological fates[J]. Int J Cancer, 2011, 128(9):1999-2009.
11. Gochman E, Mahajna J, Shenzer P, et al. The expression of iNOS and nitrotyrosine in colitis and colon cancer in humans[J]. Acta Histochem, 2012, 114(8):827-835.
12. Zhu Y, Michelle Luo T, Jobin C, et al. Gut microbiota and probiotics in colon tumorigenesis[J]. Cancer Lett, 2011, 309(2):119-127.
13. Sobhani I, Tap J, Roudot-Thoraval F, et al. Microbial dysbiosis in colorectal cancer (CRC) patients[J]. PLoS One, 2011, 6(1):e16393.
14. Shen XJ, Rawls JF, Randall T, et al. Molecular characterization of mucosal adherent bacteria and associations with colorectal adenomas[J]. Gut Microbes, 2010, 1(3):138-147.
15. Speare GS. Melanosis coli:experimental observations of its production and elimination in 23 cases[J]. Am J Surg, 1951, 82(5):631-637.
16. Virchow R. Die pathologischen piganente[J]. Virchows Arch Patbol Anat, 1847, 1(2):379-486.
17. Tikkanen L, Matsushima T, Natori S. Mutagenicity of anthraquinones in the Salmonella preincubation test[J]. Mutat Res, 1983, 116(3-4):297-304.
18. Westendorf J, Marquardt H, Poginsky B, et al. Genotoxi-city of naturally occurring hydroxyanthraquinones[J]. Murat Res, 1990, 240(1):1-12.
19. 子樹明, 崔龍, 楊明.結腸黑變病與結腸直腸息肉、結腸直腸癌的關系[J].外科理論與實踐, 2010, 15(2):188-190.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Dolichocolon with Colorectal Cancer: Report of 17 Cases and Review of The Literatures

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