Precise Dissection of Lymph Node Guided by Carbon Nanoparticles in Reoperation for Thyroid Cancer Recurrence_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 ZHAOWan-Jun ¹ , LUOHan ¹ , GOUZe-hui ² , WEITao ¹ , LIZHi-hui ¹ , GONGRi-xiang ¹ ,  ZHUJing-qiang ¹

1. Center for Diagnosis and Treatment of Thyriod and Parathyroid Diseases, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China;
2. Ultrasound Department, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China;

Corresponding?author：

ZHUJing-qiang, Email: zjq-wkys@163.com

Keywords：

Thyroid cancer; Reoperation; Carbon nanoparticles; Lymphatic mapping

DOI：

10.7507/1007-9424.20160314

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To investigate the value of carbon nanoparticle adopted in reoperation for thyroid cancer recurrence. Methods From July to November of 2015, patients diagnosed with thyroid cancer recurrence in department of Thyroid & Parathyroid surgery, West China Hospital, Sichuan University were enrolled in the research. All enrollment patients underwent carbon nanoparticles location guided by ultrasonography before reoperation. Relative data about surgery and location were analyzed retrospectively. Results Twenty-two patients were enrolled in the research. Mean operation time was (60.45±12.91) minutes. During surgery, a total of 405 (average 18.4) lymph nodes were harvested, and the staining rate was 71.9% (291/405). The pathological examination showed that there was a significant difference in the positive rate between carbon nanoparticles stained lymph nodes (45.0%, 131/291) and non-stained lymph nodes (5.3%, 6/114), P < 0.001. In addition, the positive rate in non-targeted stained lymph nodes was 30.2% (62/205). By contrast, it was 5.3% (6/114) in non-targeted non-stained lymph nodes. The difference showed significant significance (P < 0.001). Conclusions Adoption of carbon nanoparticles in reoperation for thyroid cancer, which improves efficiency of dissection for the non-palpable lymph nodes metastasis, is worth generalizing in clinical practice.

Citation： ZHAO Wan-Jun, LUO Han, GOU Ze-hui, WEI Tao, LI ZHi-hui, GONG Ri-xiang, ZHU Jing-qiang. Precise Dissection of Lymph Node Guided by Carbon Nanoparticles in Reoperation for Thyroid Cancer Recurrence. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(10): 1220-1224. doi: 10.7507/1007-9424.20160314 Copy

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3.	Harari A, Sippel RS, Goldstein R, et al. Successful localization of recurrent thyroid cancer in reoperative neck surgery using ultrasoundguided methylene blue dye injection. J Am Coll Surg, 2012, 215(4):555-561.
4.	Duprez R, Lebas P, Marc OS, et al. Preoperative US-guided hook-needle insertion in recurrent lymph nodes of papillary thyroid cancer:a help for the surgeon. Eur J Radiol, 2010, 73(1):40-42.
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7.	He J, Li S, Shao W, et al. Activated carbon nanoparticles or methylene blue as tracer during video-assisted thoracic surgery for lung cancer can help pathologist find the detected lymph nodes. J Surg Oncol, 2010, 102(6):676-682.
8.	郭滿, 張浩, 李偉漢, 等. 納米碳在cN_0期甲狀腺癌手術中對甲狀旁腺及喉返神經的保護作用研究. 中國醫學工程, 2015, 23(4):169, 171.
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13.	李希伍, 秦永艷. 甲狀腺乳頭狀癌手術治療效果觀察. 中國現代藥物應用, 2015, 9(22):84-85.
14.	馬海螺. 淺談甲狀腺再次手術患者并發癥的發生情況及對策. 當代醫藥論叢, 2015, 13(9):232-233.
15.	黃耿文, 楊連粵. 甲狀腺癌的再次手術治療. 中國實用外科雜志, 2004, 24(10):589-590.
16.	王莎飛. 甲狀腺癌不規范手術后再手術相關問題的探討. 基層醫學論壇, 2015, 19(31):4349-4350.
17.	Montgomery LL, Thorne AC, Van Zee KJ, et al. Isosulfan blue dye reactions during sentinel lymph node mapping for breast cancer. Anesth Analg, 2002, 95(2):385-388.
18.	Yang F, Jin C, Yang D, et al. Magnetic functionalised carbon nanotubes as drug vehicles for cancer lymph node metastasis treatment. Eur J Cancer, 2011, 47(12):1873-1882.
19.	Langlois SL, Carter ML. Carbon localisation of impalpable mammographic abnormalities. Australas Radiol, 1991, 35(3):237-241.
20.	Sperry K. Tattoos and tattooing. Part Ⅱ:Gross pathology, histopathology, medical complications, and applications. Am J Forensic Med Pathol, 1992, 13(1):7-17.
21.	Magrez A, Kasas S, Salicio V, et al. Cellular toxicity of carbon-based nanomaterials. Nano Lett, 2006, 6(6):1121-1125.
22.	Kang TW, Shin JH, Han BK, et al. Preoperative ultrasound-guided tattooing localization of recurrences after thyroidectomy:safety and effectiveness. Ann Surg Oncol, 2009, 16(6):1655-1659.
23.	Chami L, Hartl D, Leboulleux S, et al. Preoperative localization of neck recurrences from thyroid cancer:charcoal tattooing under ultrasound guidance. Thyroid, 2015, 25(3):341-346.
24.	Hartl DM, Chami L, Al Ghuzlan A, et al. Charcoal suspension tattoo localization for differentiated thyroid cancer recurrence. Ann Surg Oncol, 2009, 16(9):2602-2608.
25.	Kwon H, Tae SY, Kim SJ, et al. Role of charcoal tattooing in localization of recurred papillary thyroid carcinoma:initial experiences. Ann Surg Treat Res, 2015, 88(3):140-144.
26.	Soprani F, Bondi F, Puccetti M, et al. Charcoal tattoo localization for differentiatedthyroid cancer recurrence in the centralcompartment of the neck. Acta Otorhinolaryngol Ital, 2012, 32(2):87-92.

1. Johnson NA, Tublin ME. Postoperative surveillance of differentiated thyroid carcinoma:rationale, techniques, and controversies. Radiology, 2008, 249(2):429-444.
2. Francis GL, Waguespack SG, Bauer AJ, et al. Management guidelines for children with thyroid nodules and differentiated thyroid cancer. Thyroid, 2015, 25(7):716-759.
3. Harari A, Sippel RS, Goldstein R, et al. Successful localization of recurrent thyroid cancer in reoperative neck surgery using ultrasoundguided methylene blue dye injection. J Am Coll Surg, 2012, 215(4):555-561.
4. Duprez R, Lebas P, Marc OS, et al. Preoperative US-guided hook-needle insertion in recurrent lymph nodes of papillary thyroid cancer:a help for the surgeon. Eur J Radiol, 2010, 73(1):40-42.
5. Mathieu MC, Bonhomme-Faivre L, Rouzier R, et al. Tattooing breast cancers treated with neoadjuvant chemotherapy. Ann Surg Oncol, 2007, 14(8):2233-2238.
6. Naveau S, Bonhomme L, Preaux N, et al. A pure charcoal suspension for colonoscopic tattoo. Gastrointest Endosc, 1991, 37(6):624-625.
7. He J, Li S, Shao W, et al. Activated carbon nanoparticles or methylene blue as tracer during video-assisted thoracic surgery for lung cancer can help pathologist find the detected lymph nodes. J Surg Oncol, 2010, 102(6):676-682.
8. 郭滿, 張浩, 李偉漢, 等. 納米碳在cN_0期甲狀腺癌手術中對甲狀旁腺及喉返神經的保護作用研究. 中國醫學工程, 2015, 23(4):169, 171.
9. 朱精強, 汪洵理, 魏濤, 等. 納米碳甲狀旁腺負顯影辨認保護技術在甲狀腺癌手術中的應用. 中國普外基礎與臨床雜志, 2013, 20(9):992-994.
10. Al-Saif O, Farrar WB, Bloomston M, et al. Long-term efficacy of lymph node reoperation for persistent papillary thyroid cancer. J Clin Endocrinol Metab, 2010, 95(5):2187-2194.
11. Schuff KG, Weber SM, Givi B, et al. Efficacy of nodal dissection for treatment of persistent/recurrent papillary thyroid cancer. Laryngoscope, 2008, 118(5):768-775.
12. Urken ML, Milas M, Randolph GW, et al. Management of recurrent and persistent metastatic lymph nodes in well-differentiated thyroid cancer:a multifactorial decision-making guide for the Thyroid Cancer Care Collaborative. Head Neck, 2015, 37(4):605-614.
13. 李希伍, 秦永艷. 甲狀腺乳頭狀癌手術治療效果觀察. 中國現代藥物應用, 2015, 9(22):84-85.
14. 馬海螺. 淺談甲狀腺再次手術患者并發癥的發生情況及對策. 當代醫藥論叢, 2015, 13(9):232-233.
15. 黃耿文, 楊連粵. 甲狀腺癌的再次手術治療. 中國實用外科雜志, 2004, 24(10):589-590.
16. 王莎飛. 甲狀腺癌不規范手術后再手術相關問題的探討. 基層醫學論壇, 2015, 19(31):4349-4350.
17. Montgomery LL, Thorne AC, Van Zee KJ, et al. Isosulfan blue dye reactions during sentinel lymph node mapping for breast cancer. Anesth Analg, 2002, 95(2):385-388.
18. Yang F, Jin C, Yang D, et al. Magnetic functionalised carbon nanotubes as drug vehicles for cancer lymph node metastasis treatment. Eur J Cancer, 2011, 47(12):1873-1882.
19. Langlois SL, Carter ML. Carbon localisation of impalpable mammographic abnormalities. Australas Radiol, 1991, 35(3):237-241.
20. Sperry K. Tattoos and tattooing. Part Ⅱ:Gross pathology, histopathology, medical complications, and applications. Am J Forensic Med Pathol, 1992, 13(1):7-17.
21. Magrez A, Kasas S, Salicio V, et al. Cellular toxicity of carbon-based nanomaterials. Nano Lett, 2006, 6(6):1121-1125.
22. Kang TW, Shin JH, Han BK, et al. Preoperative ultrasound-guided tattooing localization of recurrences after thyroidectomy:safety and effectiveness. Ann Surg Oncol, 2009, 16(6):1655-1659.
23. Chami L, Hartl D, Leboulleux S, et al. Preoperative localization of neck recurrences from thyroid cancer:charcoal tattooing under ultrasound guidance. Thyroid, 2015, 25(3):341-346.
24. Hartl DM, Chami L, Al Ghuzlan A, et al. Charcoal suspension tattoo localization for differentiated thyroid cancer recurrence. Ann Surg Oncol, 2009, 16(9):2602-2608.
25. Kwon H, Tae SY, Kim SJ, et al. Role of charcoal tattooing in localization of recurred papillary thyroid carcinoma:initial experiences. Ann Surg Treat Res, 2015, 88(3):140-144.
26. Soprani F, Bondi F, Puccetti M, et al. Charcoal tattoo localization for differentiatedthyroid cancer recurrence in the centralcompartment of the neck. Acta Otorhinolaryngol Ital, 2012, 32(2):87-92.

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Precise Dissection of Lymph Node Guided by Carbon Nanoparticles in Reoperation for Thyroid Cancer Recurrence

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