The research progress of magnetic resonance quantitative technique in the iron overload of the abdominal parenchyma organ_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHOU Yi ,  SONG Bin , HU Fubi , YUAN Fang

Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, P. R. China;

Corresponding?author：

SONG Bin, Email: anicesong@vip.sina.com

Keywords：

iron overload; magnetic resonance quantitative technique; abdomen

DOI：

10.7507/1007-9424.201707066

Video：

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Objective To summarize the research progress of magnetic resonance quantitative technique in the iron overload of the abdominal parenchyma organ. Methods By reviewing the related literatures domesticly and abroad, the present status and progress of abdominal magnetic resonance quantitative technique and other examinations in the study of iron overload were analyzed. Results MRI multi-sequence examination technique had changed the research model of iron overload in different organs, and had important clinical significance in imaging diagnosis of abdominal parenchyma organ damage. so far, many techniques of MRI had been used in detection of iron overload, which included signal intensity measurements(including signal intensity ratio and signal intensity difference of positive and negative phases), T2/R2 measurements, T2^*/R2^* measurements, Dixon and its derivatization, ultrashort echo time technique and susceptibility weighted imaging (including conventional susceptibility weighted imaging and quantitative magnetic sensitive imaging). Conclusion Magnetic resonance quantitative examination technique is expected to be the first choice for detection of hepatic iron overload, and can improve the early detection rate of iron overload pancreatic damage.

Citation： ZHOU Yi, SONG Bin, HU Fubi, YUAN Fang. The research progress of magnetic resonance quantitative technique in the iron overload of the abdominal parenchyma organ. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2017, 24(9): 1139-1144. doi: 10.7507/1007-9424.201707066 Copy

1.	孟昭升, 賈紅英, 吳學瓊, 等. 鐵代謝及鐵過載. 醫學綜述, 2012, 18(1): 43-46.
2.	Wunderlich AP, Cario H, Juchems MS, et al. Noninvasive MRI-based liver iron quantification: methodic approaches, practical applicability and significance. Rofo, 2016, 188(11): 1031-1036.
3.	孫磊, 王鵬, 張亮, 等. 血色病肝臟鐵沉積的病理特點分析. 中華肝臟病雜志, 2015, 6(23): 443-448.
4.	宋曉麗, 趙俊功, 程英升. MRI 評價肝臟鐵過載的應用進展. 世界華人消化雜志, 2012, 20(21): 1933-1938.
5.	張子義, 劉培國, 張亮, 等. 磁感應法檢測肝臟鐵過載的原理分析與仿真. 中國醫學物理學雜志, 2013, 32(1): 3927-3932. .
6.	金明麗, 舒健. 肝臟鐵質濃度測量的研究進展. 瀘州醫學院學報, 2016, 39(1): 79-81.
7.	Wood JC. Use of magnetic resonance imaging to monitor iron overload. Hematol Oncol Clin North Am, 2014, 28(4): 747-764.
8.	Wood JC. Estimating tissue iron burden: current status and future prospects. Br J Haematol, 2015, 170(1): 15-28.
9.	張倩, 侯波, 王璐, 等. 磁共振成像技術在鐵過載診斷及隨訪中的應用. 中華血液學雜志, 2015, 36(4): 302-306.
10.	曹小立, 趙明峰. 鐵過載對器官功能損傷及磁共振檢測鐵過載研究進展. 中國實用內科雜志, 2014, 34(12): 1226-1228.
11.	olouian R, Mulla ZD, Diaz J, et al. Liver and cardiac iron deposition in patients on maintenance hemodialysis by magnetic resonance imaging T2. Iran J Kidney Dis, 2016, 10(2): 68-74.
12.	Ernst O, Sergent G, Bonvarlet P, et al. Hepatic iron overload: diagnosis and quantification with MR imaging. AJR Am J Roentgenol, 1997, 168(5): 1205-1208.
13.	Bonetti MG, Castriota-Scanderbeg A, Criconia GM, et al. Hepatic iron overload in thalassemic patients: proposal and validation of an MRI method of assessment. Pediatr Radiol, 1996, 26(9): 650-656.
14.	肖超, 顧樹程, 徐燕軍, 等. 磁共振成像用于血液病患者鐵過載評估的初步研究. 中華血液學雜志, 2015, 36(12): 1039-1042.
15.	李春燕, 黃仲奎, 龍莉玲, 等. MRI 測量 R₂ 值與鐵濃度的相關性. 實用放射學雜志, 2015, 31(11): 1872-1875.
16.	Ghugre NR, Coates TD, Nelson MD, et al. Mechanisms of tissue-iron relaxivity: nuclear magnetic resonance studies of human liver biopsy specimens. Magn Reson Med, 2005, 54(5): 1185-1193.
17.	Hernando D, Cook RJ, Diamond C, et al. Magnetic susceptibility as a B0 field strength independent MRI biomarker of liver iron overload. Magn Reson Med, 2013, 70(3): 648-656.
18.	Hernando D, Levin YS, Sirlin CB, et al. Quantification of liver iron with MRI: state of the art and remaining challenges. J Magn Reson Imaging, 2014, 40(5): 1003-1021.
19.	St Pierre TG, El-Beshlawy A, Elalfy M, et al. Multicenter validation of spin-density projection-assisted R2-MRI for the noninvasive measurement of liver iron concentration. Magn Reson Med, 2014, 71(6): 2215-2223.
20.	?dilman ?S, Gümrük F, Halilo?lu M, et al. The feasibility of magnetic resonance imaging for quantification of liver, pancreas, spleen, vertebral bone marrow, and renal cortex R2^* and proton density fat fraction in transfusion-related iron overload. Turk J Haematol, 2016, 33(1): 21-27.
21.	Ibrahim EH, Khalifa AM, Eldaly AK. MRI T2^* imaging for assessment of liver iron overload: study of different data analysis approaches. Acta Radiol, 2016, 57(12): 1453-1459.
22.	Verlhac S, Morel M, Bernaudin F, et al. Liver iron overload assessment by MRI R2^* relaxometry in highly transfused pediatric patients: an agreement and reproducibility study. Diagn Interv Imaging, 2015, 96(3): 259-264.
23.	Yokoo T, Yuan Q, Sénégas J, et al. Quantitative R2^* MRI of the liver with rician noise models for evaluation of hepatic iron overload: simulation, phantom, and early clinical experience. J Magn Reson Imaging, 2015, 42(6): 1544-1559.
24.	Alústiza JM, Castiella A, De Juan MD, et al. Iron overload in the liver diagnostic and quantification. Eur J Radiol, 2007, 61(3): 499-506.
25.	金晶蘭, 趙旭, 李光明, 等. 美國肝病學會血色病診治指南要點. 臨床肝膽病雜志, 2013, 29(5): 403-405.
26.	Chandarana H, Lim RP, Jensen JH, et al. Hepatic iron deposition in patients with liver disease: preliminary experience with breath-hold multiecho T2^*-weighted sequence. AJR Am J Roentgenol, 2009, 193(5): 1261-1267.
27.	范振平, 石紅霞, 張文瑾, 等. 1991～2010 年國內血色病薈萃分析. 臨床薈萃, 2011, 26(24): 2132-2136.
28.	Anderson LJ. Assessment of iron overload with T2^* magnetic resonance imaging. Prog Cardiovasc Dis, 2011, 54(3): 287-294.
29.	Sanches-Rocha L, Serpa B, Figueiredo E, et al. Comparison between multi-echo T2^* with and without fat saturation pulse for quantification of liver iron overload. Magn Reson Imaging, 2013, 31(10): 1704-1708.
30.	Doyle EK, Toy K, Valdez B, et al. Ultra-short echo time images quantify high liver iron. Magn Reson Med, 2017, [Epub ahead of print].
31.	Tipirneni-Sajja A, Krafft AJ, McCarville MB, et al. Radial ultrashort TE imaging removes the need for breath-holding in hepatic iron overload quantification by R2^* MRI. AJR Am J Roentgenol, 2017, 209(1): 187-194.
32.	程雙娟, 肖江喜. SWI 在腦內鐵過載中的應用. 國際醫學放射學雜志, 2015, 38(1): 16-19, 29.
33.	Li RK, Zeng MS, Qiang JW, et al. Improving detection of iron deposition in cirrhotic liver using susceptibility-weighted imaging with emphasis on histopathological correlation. J Comput Assist Tomogr, 2017, 41(1): 18-24.
34.	Liu S, Buch S, Chen Y, et al. Susceptibility-weighted imaging: current status and future directions. NMR Biomed, 2017, 30(4): [Epub ahead of print].
35.	Sharma SD, Hernando D, Horng DE, et al. Quantitative susceptibility mapping in the abdomen as an imaging biomarker of hepatic iron overload. Magn Reson Med, 2015, 74(3): 673-683.
36.	Sharma SD, Fischer R, Schoennagel BP, et al. MRI-based quantitative susceptibility mapping (QSM) and R2^* mapping of liver iron overload: comparison with SQUID-based biomagnetic liver susceptometry. Magn Reson Med, 2017, 78(1): 264-270.

1. 孟昭升, 賈紅英, 吳學瓊, 等. 鐵代謝及鐵過載. 醫學綜述, 2012, 18(1): 43-46.
2. Wunderlich AP, Cario H, Juchems MS, et al. Noninvasive MRI-based liver iron quantification: methodic approaches, practical applicability and significance. Rofo, 2016, 188(11): 1031-1036.
3. 孫磊, 王鵬, 張亮, 等. 血色病肝臟鐵沉積的病理特點分析. 中華肝臟病雜志, 2015, 6(23): 443-448.
4. 宋曉麗, 趙俊功, 程英升. MRI 評價肝臟鐵過載的應用進展. 世界華人消化雜志, 2012, 20(21): 1933-1938.
5. 張子義, 劉培國, 張亮, 等. 磁感應法檢測肝臟鐵過載的原理分析與仿真. 中國醫學物理學雜志, 2013, 32(1): 3927-3932. .
6. 金明麗, 舒健. 肝臟鐵質濃度測量的研究進展. 瀘州醫學院學報, 2016, 39(1): 79-81.
7. Wood JC. Use of magnetic resonance imaging to monitor iron overload. Hematol Oncol Clin North Am, 2014, 28(4): 747-764.
8. Wood JC. Estimating tissue iron burden: current status and future prospects. Br J Haematol, 2015, 170(1): 15-28.
9. 張倩, 侯波, 王璐, 等. 磁共振成像技術在鐵過載診斷及隨訪中的應用. 中華血液學雜志, 2015, 36(4): 302-306.
10. 曹小立, 趙明峰. 鐵過載對器官功能損傷及磁共振檢測鐵過載研究進展. 中國實用內科雜志, 2014, 34(12): 1226-1228.
11. olouian R, Mulla ZD, Diaz J, et al. Liver and cardiac iron deposition in patients on maintenance hemodialysis by magnetic resonance imaging T2. Iran J Kidney Dis, 2016, 10(2): 68-74.
12. Ernst O, Sergent G, Bonvarlet P, et al. Hepatic iron overload: diagnosis and quantification with MR imaging. AJR Am J Roentgenol, 1997, 168(5): 1205-1208.
13. Bonetti MG, Castriota-Scanderbeg A, Criconia GM, et al. Hepatic iron overload in thalassemic patients: proposal and validation of an MRI method of assessment. Pediatr Radiol, 1996, 26(9): 650-656.
14. 肖超, 顧樹程, 徐燕軍, 等. 磁共振成像用于血液病患者鐵過載評估的初步研究. 中華血液學雜志, 2015, 36(12): 1039-1042.
15. 李春燕, 黃仲奎, 龍莉玲, 等. MRI 測量 R₂ 值與鐵濃度的相關性. 實用放射學雜志, 2015, 31(11): 1872-1875.
16. Ghugre NR, Coates TD, Nelson MD, et al. Mechanisms of tissue-iron relaxivity: nuclear magnetic resonance studies of human liver biopsy specimens. Magn Reson Med, 2005, 54(5): 1185-1193.
17. Hernando D, Cook RJ, Diamond C, et al. Magnetic susceptibility as a B0 field strength independent MRI biomarker of liver iron overload. Magn Reson Med, 2013, 70(3): 648-656.
18. Hernando D, Levin YS, Sirlin CB, et al. Quantification of liver iron with MRI: state of the art and remaining challenges. J Magn Reson Imaging, 2014, 40(5): 1003-1021.
19. St Pierre TG, El-Beshlawy A, Elalfy M, et al. Multicenter validation of spin-density projection-assisted R2-MRI for the noninvasive measurement of liver iron concentration. Magn Reson Med, 2014, 71(6): 2215-2223.
20. ?dilman ?S, Gümrük F, Halilo?lu M, et al. The feasibility of magnetic resonance imaging for quantification of liver, pancreas, spleen, vertebral bone marrow, and renal cortex R2^* and proton density fat fraction in transfusion-related iron overload. Turk J Haematol, 2016, 33(1): 21-27.
21. Ibrahim EH, Khalifa AM, Eldaly AK. MRI T2^* imaging for assessment of liver iron overload: study of different data analysis approaches. Acta Radiol, 2016, 57(12): 1453-1459.
22. Verlhac S, Morel M, Bernaudin F, et al. Liver iron overload assessment by MRI R2^* relaxometry in highly transfused pediatric patients: an agreement and reproducibility study. Diagn Interv Imaging, 2015, 96(3): 259-264.
23. Yokoo T, Yuan Q, Sénégas J, et al. Quantitative R2^* MRI of the liver with rician noise models for evaluation of hepatic iron overload: simulation, phantom, and early clinical experience. J Magn Reson Imaging, 2015, 42(6): 1544-1559.
24. Alústiza JM, Castiella A, De Juan MD, et al. Iron overload in the liver diagnostic and quantification. Eur J Radiol, 2007, 61(3): 499-506.
25. 金晶蘭, 趙旭, 李光明, 等. 美國肝病學會血色病診治指南要點. 臨床肝膽病雜志, 2013, 29(5): 403-405.
26. Chandarana H, Lim RP, Jensen JH, et al. Hepatic iron deposition in patients with liver disease: preliminary experience with breath-hold multiecho T2^*-weighted sequence. AJR Am J Roentgenol, 2009, 193(5): 1261-1267.
27. 范振平, 石紅霞, 張文瑾, 等. 1991～2010 年國內血色病薈萃分析. 臨床薈萃, 2011, 26(24): 2132-2136.
28. Anderson LJ. Assessment of iron overload with T2^* magnetic resonance imaging. Prog Cardiovasc Dis, 2011, 54(3): 287-294.
29. Sanches-Rocha L, Serpa B, Figueiredo E, et al. Comparison between multi-echo T2^* with and without fat saturation pulse for quantification of liver iron overload. Magn Reson Imaging, 2013, 31(10): 1704-1708.
30. Doyle EK, Toy K, Valdez B, et al. Ultra-short echo time images quantify high liver iron. Magn Reson Med, 2017, [Epub ahead of print].
31. Tipirneni-Sajja A, Krafft AJ, McCarville MB, et al. Radial ultrashort TE imaging removes the need for breath-holding in hepatic iron overload quantification by R2^* MRI. AJR Am J Roentgenol, 2017, 209(1): 187-194.
32. 程雙娟, 肖江喜. SWI 在腦內鐵過載中的應用. 國際醫學放射學雜志, 2015, 38(1): 16-19, 29.
33. Li RK, Zeng MS, Qiang JW, et al. Improving detection of iron deposition in cirrhotic liver using susceptibility-weighted imaging with emphasis on histopathological correlation. J Comput Assist Tomogr, 2017, 41(1): 18-24.
34. Liu S, Buch S, Chen Y, et al. Susceptibility-weighted imaging: current status and future directions. NMR Biomed, 2017, 30(4): [Epub ahead of print].
35. Sharma SD, Hernando D, Horng DE, et al. Quantitative susceptibility mapping in the abdomen as an imaging biomarker of hepatic iron overload. Magn Reson Med, 2015, 74(3): 673-683.
36. Sharma SD, Fischer R, Schoennagel BP, et al. MRI-based quantitative susceptibility mapping (QSM) and R2^* mapping of liver iron overload: comparison with SQUID-based biomagnetic liver susceptometry. Magn Reson Med, 2017, 78(1): 264-270.

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The research progress of magnetic resonance quantitative technique in the iron overload of the abdominal parenchyma organ

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