Efficacy of Triple Aerosol Inhalation of Pulmicort Respules,Ipratropine and Ventolin in Treatment of Severe Acute Asthma Exacerbations in Adults_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

LiRu ¹ , ChenYifei ² ,  JiaJun ¹

1. Department of Respiratory Medicine, Wuchang Hospital, Wuhan, Hubei, 430063, China;
2. ;

Corresponding?author：

JiaJun, Email: 1150198926@qq.com

Keywords：

Severe asthma; Pulmicort respules; Ipratropine; Ventolin; Aerosol inhalation

DOI：

10.7507/1671-6205.2014070

Video：

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Objective To observe the clinical efficacy of triple aerosol inhalation of pulmicort respules,ipratropine and ventolin in treatment of severe acute asthma exacerbations in adults. Methods 46 cases of severe asthmatic patients with acute exacerbations admitted between May 2011 and May 2013 were recruited in the study.They were randomly divided into a treatment group and a control group,23 cases in each group.The control group received aminophylline and methylprednisolone intravenously,while the treatment group received triple aerosol inhalation of pulmicort respules,ipratropine and ventolin on the basic treatment of the control group.The clinical efficacy,the score of asthma symptom of the day and night,the time of disappearance of symptoms and wheezing sound,the glucocorticoid dosage and the incidence of adverse reactions of each group were compared. Results Comparison of clinical efficacy of two groups drew significant differences (P<0.05) after 7 days.The score of asthma symptom of the day and night in the treatment group was lower than that of the control group (P<0.05).Except cough,the duration of wheezing,breathlessness,chest distress and extinction time of wheezing sound in the treatment group were shorter than those in the control group (P<0.05).The triple inhalation therapy can reduce the dosage and shorten the period of intravenous glucocorticoid treatment with slight adverse reactions (P<0.05). Conclusion In the treatment of severe asthmatic patients with acute exacerbations,the clinical efficacy of triple aerosol inhalation of pulmicort respules,ipratropine and ventolin on the base of intravenous treatment is satisfactory with rapid onset,which can also reduce the glucocorticoid dosage and the incidence of adverse reactions.So the combination therapy is worthy of clinical use.

Citation： LiRu, ChenYifei, JiaJun. Efficacy of Triple Aerosol Inhalation of Pulmicort Respules,Ipratropine and Ventolin in Treatment of Severe Acute Asthma Exacerbations in Adults. Chinese Journal of Respiratory and Critical Care Medicine, 2014, 13(3): 291-294. doi: 10.7507/1671-6205.2014070 Copy

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1. Fanta CH.Asthma.N Engl J Med,2009,360:1002-1014.
2. Grover S,Jindal A,Bansal A,et al.Acute bronchial asthma.Indian J Pediatr,2011,78:1388-1395.
3. 劉春濤.支氣管哮喘的急診處理.中國呼吸與危重監護雜志,2002,1:185-189.
4. Global Initiative for Asthma (GINA).Global strategy for asthma management and prevention (Updated 2011).Available at:www.ginaasthma.org.
5. 劉春濤.哮喘管理和預防袖珍指南(2006年修訂版)——根據哮喘管理和預防的全球策略.中國呼吸與危重監護雜志,2007,6:148-158.
6. 中華醫學會呼吸病學分會哮喘學組.支氣管哮喘防治指南(支氣管哮喘的定義、診斷、治療和管理方案).中華哮喘雜志:電子版,2008,2:3-13.
7. 全國哮喘防治協作組.支氣管哮喘防治指南.中華結核和呼吸雜志,1997,20:261-267.
8. 曹秋梅.支氣管哮喘急性發作的藥物治療.臨床藥物治療雜志,2011,9:48-52.
9. 張雅衛,謝紅,曾小麗.兩種劑量甲基潑尼松龍聯合機械通氣治療重癥哮喘療效觀察.中國醫學工程,2011,19:142-143.
10. Blewett AJ,Varma D,Gilles T,et al.Development and validation of a stability-indicating high-performance liquid chromatography method for the simultaneous determination of albuterol,budesonide,and ipratropium bromide in compounded nebulizer solutions.JAOAC Int,2011,94:110-117.

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Efficacy of Triple Aerosol Inhalation of Pulmicort Respules,Ipratropine and Ventolin in Treatment of Severe Acute Asthma Exacerbations in Adults

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