毒蕈堿樣膽堿能受體在慢性阻塞性肺疾病防治中的研究進展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

黃曉芬 , 李金田 , 張毅 , 孫少伯 ,  李娟 , 余森豪

甘肅中醫藥大學敦煌醫學與轉化教育部重點實驗室中藥藥理與毒理學省級重點實驗室（甘肅蘭州 730000）;

Corresponding?author：

李娟, Email: gansulijuan@sina.com

Keywords：

DOI：

10.7507/1671-6205.2016024

Video：

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Citation： 黃曉芬, 李金田, 張毅, 孫少伯, 李娟, 余森豪. 毒蕈堿樣膽堿能受體在慢性阻塞性肺疾病防治中的研究進展. Chinese Journal of Respiratory and Critical Care Medicine, 2016, 15(1): 95-98. doi: 10.7507/1671-6205.2016024 Copy

1.	Kistemaker LE, Oenema TA, Meurs H, et al. Regulation of airway inflammation and remodeling by muscarinic receptors:perspectives on anticholinergic therapy in asthma and COPD. Life Sciences, 2012, 91:1126-1133.
2.	Hu J, Thor D, Zhou Y, et al.Structural aspect of M3 muscarinic acetylcholine receptor dimer formation and activation. FASEB J, 2012, 2:604-616.
3.	孫科.M受體-G蛋白信號轉導途徑研究進展.國際藥學研究雜志, 2008, 35:87-90.
4.	Ikeda T, Anisuzzaman AS, Yoshiki H, et al. Regional quantification of muscarinic acetylcholine receptors andβ-adrenoceptors in human airways. Br J Pharmacol, 2012, 166:1804-1814.
5.	王海波, 張海鵬.毒蕈堿乙酰膽堿受體表達和功能的調節及其介導新的信號途徑.國外醫學(生理、病理科學與臨床分冊), 2003, 23:76-78.
6.	Jiang ST, Li YF, Zhang CL.et al.M1 muscarinic acetylcholine receptor in Alzheimer's disease. Neurosci Bull, 2014, 30:295-307.
7.	姚婉貞, 王國揚.慢性阻塞性肺疾病的氣道毒蕈堿M受體變化與抗膽堿治療的研究.中華結核和呼吸雜志, 2005, 28:484-485.
8.	Lammers JW, Minette P, McCusker M, et al. The role of prinzepine-sensitive (M1) muscarinic receptors in vagally mediated bronchoconstriction in humans. Am Rev Respir Dis, 1989, 139:446-449.
9.	Fisher JT, Vincent SG, Gomeza J, et al. Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking M2 or M3 muscarinic acetylcholine receptors. FASEB J, 2010, 18:711-713.
10.	Milara J, Serrano A, Peiró T, et al.Aclidinium inhibits human lung fibroblast to myofibroblast transition. Thorax, 2012, 67:229-237.
11.	Billington CK, Penn RB.M3 muscarinic acetylcholine receptor regulation in the airway. Am Respir Cell Mol Biol, 2002, 26:269-272.
12.	Cao R, Dong XW, Jiang JX, et al. M3 muscarinic receptor antagonist bencycloquidium bromide attenuates allergic airway inflammation, hyperresponsiveness and remodeling in mice. Eur J Pharmacol, 2011, 655:83-90.
13.	Selivanova PA, Kulikov ES, Kozina OV, et al. Differential expression of theβ, 2-adrenoreceptor and M3-cholinoreceptor genes in bronchial mucosa of patients with asthma and chronic obstructive pulmonary disease. Ann Allergy Asthma Immunol, 2012, 108:39-43.
14.	董廣鋒, 劉瑞娟, 郭興華.噻托溴銨抑制慢性阻塞性肺疾病氣道重塑及炎癥反應機制的研究進展.山東醫藥, 2014, 54:106-107.
15.	Rogers DF. Motor control of airway goblet cells and glands. Respir Physiol, 2001, 125:129-144.
16.	Kelly EA, Jarjour NN. Role of matrix metalloproteinases in asthma. Curr Opin Pulm Med, 2003, 9:28-33.
17.	Grainge CL, Lau LC, Ward JA, et al. Effect of bronchoconstriction on airway remodeling in asthma. N Engl J Med, 2011, 364:2006-2015.
18.	Oenema TA, Smit, Smedinga L, et al. Muscarinicreceptor stimulation augments TGF-β1-induced contractile protein expression by airway smooth muscle cells. Am J Physiol, 2012, 303:L589-L597.
19.	Bos IS, Gosens R, Zuidhof AB, et al. Inhibition of allergen-induced airway remodelling by tiotropium and budesonide:a comparison. Eur Respir J, 2007, 30:653-661.
20.	Pera T, Zuidhof A, Valadas J, et al. Tiotropium inhibits pulmonary inflammation and remodelling in a guinea pig model of COPD. Eur Respir J, 2011, 38:789-796.
21.	白新會.噻托溴銨治療穩定期慢阻肺臨床研究.當代醫學, 2011, 17:25-26.
22.	陳利, 陶玉堅, 林郁, 等.噻托溴銨粉吸入劑治療穩定期中重度COPD患者的臨床療效觀察.現代生物醫學進展, 2012, 27:5319-5321.
23.	黃錦倫.噻托溴銨粉吸入劑治療慢性阻塞性肺疾病的治療體會.中國醫學工程, 2015, 23:135.

1. Kistemaker LE, Oenema TA, Meurs H, et al. Regulation of airway inflammation and remodeling by muscarinic receptors:perspectives on anticholinergic therapy in asthma and COPD. Life Sciences, 2012, 91:1126-1133.
2. Hu J, Thor D, Zhou Y, et al.Structural aspect of M3 muscarinic acetylcholine receptor dimer formation and activation. FASEB J, 2012, 2:604-616.
3. 孫科.M受體-G蛋白信號轉導途徑研究進展.國際藥學研究雜志, 2008, 35:87-90.
4. Ikeda T, Anisuzzaman AS, Yoshiki H, et al. Regional quantification of muscarinic acetylcholine receptors andβ-adrenoceptors in human airways. Br J Pharmacol, 2012, 166:1804-1814.
5. 王海波, 張海鵬.毒蕈堿乙酰膽堿受體表達和功能的調節及其介導新的信號途徑.國外醫學(生理、病理科學與臨床分冊), 2003, 23:76-78.
6. Jiang ST, Li YF, Zhang CL.et al.M1 muscarinic acetylcholine receptor in Alzheimer's disease. Neurosci Bull, 2014, 30:295-307.
7. 姚婉貞, 王國揚.慢性阻塞性肺疾病的氣道毒蕈堿M受體變化與抗膽堿治療的研究.中華結核和呼吸雜志, 2005, 28:484-485.
8. Lammers JW, Minette P, McCusker M, et al. The role of prinzepine-sensitive (M1) muscarinic receptors in vagally mediated bronchoconstriction in humans. Am Rev Respir Dis, 1989, 139:446-449.
9. Fisher JT, Vincent SG, Gomeza J, et al. Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking M2 or M3 muscarinic acetylcholine receptors. FASEB J, 2010, 18:711-713.
10. Milara J, Serrano A, Peiró T, et al.Aclidinium inhibits human lung fibroblast to myofibroblast transition. Thorax, 2012, 67:229-237.
11. Billington CK, Penn RB.M3 muscarinic acetylcholine receptor regulation in the airway. Am Respir Cell Mol Biol, 2002, 26:269-272.
12. Cao R, Dong XW, Jiang JX, et al. M3 muscarinic receptor antagonist bencycloquidium bromide attenuates allergic airway inflammation, hyperresponsiveness and remodeling in mice. Eur J Pharmacol, 2011, 655:83-90.
13. Selivanova PA, Kulikov ES, Kozina OV, et al. Differential expression of theβ, 2-adrenoreceptor and M3-cholinoreceptor genes in bronchial mucosa of patients with asthma and chronic obstructive pulmonary disease. Ann Allergy Asthma Immunol, 2012, 108:39-43.
14. 董廣鋒, 劉瑞娟, 郭興華.噻托溴銨抑制慢性阻塞性肺疾病氣道重塑及炎癥反應機制的研究進展.山東醫藥, 2014, 54:106-107.
15. Rogers DF. Motor control of airway goblet cells and glands. Respir Physiol, 2001, 125:129-144.
16. Kelly EA, Jarjour NN. Role of matrix metalloproteinases in asthma. Curr Opin Pulm Med, 2003, 9:28-33.
17. Grainge CL, Lau LC, Ward JA, et al. Effect of bronchoconstriction on airway remodeling in asthma. N Engl J Med, 2011, 364:2006-2015.
18. Oenema TA, Smit, Smedinga L, et al. Muscarinicreceptor stimulation augments TGF-β1-induced contractile protein expression by airway smooth muscle cells. Am J Physiol, 2012, 303:L589-L597.
19. Bos IS, Gosens R, Zuidhof AB, et al. Inhibition of allergen-induced airway remodelling by tiotropium and budesonide:a comparison. Eur Respir J, 2007, 30:653-661.
20. Pera T, Zuidhof A, Valadas J, et al. Tiotropium inhibits pulmonary inflammation and remodelling in a guinea pig model of COPD. Eur Respir J, 2011, 38:789-796.
21. 白新會.噻托溴銨治療穩定期慢阻肺臨床研究.當代醫學, 2011, 17:25-26.
22. 陳利, 陶玉堅, 林郁, 等.噻托溴銨粉吸入劑治療穩定期中重度COPD患者的臨床療效觀察.現代生物醫學進展, 2012, 27:5319-5321.
23. 黃錦倫.噻托溴銨粉吸入劑治療慢性阻塞性肺疾病的治療體會.中國醫學工程, 2015, 23:135.

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