Therapeutic efficacy of GM-CSF inhalation in patients with recurrent pulmonary alveolar proteinosis_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

 LI Ying , LIU Lang , ZHANG Xiaohua , LUO Guangming , YAN Wei , YANG Long

Hunan Prevention and Treatment Central for Occupational Diseases, Changsha, Hunan 410007, P.R.China;

Corresponding?author：

LI Ying, Email: liying9858@163.com

Keywords：

Pulmonary alveolar proteinosis; Recurrent; Granulocyte-macrophage colony-stimulating factor; Inhalation

DOI：

10.7507/1671-6205.201608008

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To evaluate therapeutic efficacy and safety of recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) inhalation in patients with recurrent pulmonarv alveolar proteinosis (PAP). Methods Three cases of recurrent PAP were treated by GM-CSF inhalation after whole lung lavage. The clinical data of the pulmonary function and SpO ₂, the clinical symptoms and pulmonary lesions were compared before and after treatment. Results The pulmonary function and manifestations were improved obviously after GM-CSF inhalation. Also the ground-glass opacity was improved in high-resolution CT. The pulmonary function and SpO ₂ increased obviously after received GM-CSF inhalation. There were no any adverse reactions in 3 cases. Conclusion GM-CSF inhalation therapy is effective and safe in recurrent PAP, but the long-term effect remains to be seen.

Citation： LI Ying, LIU Lang, ZHANG Xiaohua, LUO Guangming, YAN Wei, YANG Long. Therapeutic efficacy of GM-CSF inhalation in patients with recurrent pulmonary alveolar proteinosis. Chinese Journal of Respiratory and Critical Care Medicine, 2017, 16(3): 271-273. doi: 10.7507/1671-6205.201608008 Copy

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2.	Tazawa R, Trapnell BC, Inoue Y, et al. Inhaled granulocyte/macrophage-colony stimulating factor as therapy for pulmonary alveolar proteinosis. Am J Respir Crit Care Med, 2010, 181(12): 1345-1354.
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7.	王婷, 張杰, 王娟, 等. 全肺灌洗聯合皮下注射粒細胞巨噬細胞集落刺激因子治療肺泡蛋白沉積癥一例. 中華結核和呼吸雜志, 2010, 33(12): 947-949.
8.	Venkateshiah SB, Yah TD, Bonfield TL, et al. An open-label trial of granulocyte macrophage colony stimulating factor therapy for moderate symptomatic pulmonary alveolar proteinosis. Chest, 2006, 130(1): 227-237.
9.	高天敏. 大容量全肺灌洗聯合皮下注射重組人粒細胞-巨噬細胞集落刺激因子治療肺泡蛋白沉積癥一例報道. 中國呼吸與危重監護雜志, 2014, 13(1): 89-91.
10.	Wylam ME, Ten R, Prakash UB, et al. Aerosol granulocytemaerophage colony-stimulating factor for pulmonary alveolar proteinosis. Eur Respir J, 2006, 27(3): 585-593.
11.	郭文亮, 曾運祥, 蘇柱泉, 等. 粒細胞-巨噬細胞集落刺激因子霧化吸入治療自身免疫性肺泡蛋白沉積癥一例并文獻復習. 中華結核和呼吸雜志, 2015, 38(10): 751-755.
12.	陳紅波, 張承云, 程德云, 等. 特發性肺泡蛋白沉積癥全肺灌洗和粒細胞-巨噬細胞集落刺激因子吸入治療療效觀察. 臨床內科雜志, 2010, 27(3): 168-170.

1. Ioachimescu OC, Karuru MS. Pulmonary alveolar proteinosis. Chron Respire Dis, 2006, 3(3): 149-159.
2. Tazawa R, Trapnell BC, Inoue Y, et al. Inhaled granulocyte/macrophage-colony stimulating factor as therapy for pulmonary alveolar proteinosis. Am J Respir Crit Care Med, 2010, 181(12): 1345-1354.
3. 朱元玨, 陳文彬. 呼吸病學. 北京: 人民衛生出版社, 2002, 1106-1111.
4. 徐蕭洪, 宋作慶, 范賢明. 肺泡蛋白沉積癥的研究進展. 國際呼吸雜志, 2006, 26(11): 856-859.
5. 李穎, 嚴薇, 張曉華, 等. 肺泡蛋白沉積癥 34 例臨床診治分析. 中國呼吸與危重監護雜志, 2016, 15(4): 398-400.
6. 沈毅弘, 趙瓊, 陸國華, 等. 粒細胞-巨噬細胞集落刺激因子治療特發性肺泡蛋白沉積癥一例. 中華結核和呼吸雜志, 2009, 32(1): 62-63.
7. 王婷, 張杰, 王娟, 等. 全肺灌洗聯合皮下注射粒細胞巨噬細胞集落刺激因子治療肺泡蛋白沉積癥一例. 中華結核和呼吸雜志, 2010, 33(12): 947-949.
8. Venkateshiah SB, Yah TD, Bonfield TL, et al. An open-label trial of granulocyte macrophage colony stimulating factor therapy for moderate symptomatic pulmonary alveolar proteinosis. Chest, 2006, 130(1): 227-237.
9. 高天敏. 大容量全肺灌洗聯合皮下注射重組人粒細胞-巨噬細胞集落刺激因子治療肺泡蛋白沉積癥一例報道. 中國呼吸與危重監護雜志, 2014, 13(1): 89-91.
10. Wylam ME, Ten R, Prakash UB, et al. Aerosol granulocytemaerophage colony-stimulating factor for pulmonary alveolar proteinosis. Eur Respir J, 2006, 27(3): 585-593.
11. 郭文亮, 曾運祥, 蘇柱泉, 等. 粒細胞-巨噬細胞集落刺激因子霧化吸入治療自身免疫性肺泡蛋白沉積癥一例并文獻復習. 中華結核和呼吸雜志, 2015, 38(10): 751-755.
12. 陳紅波, 張承云, 程德云, 等. 特發性肺泡蛋白沉積癥全肺灌洗和粒細胞-巨噬細胞集落刺激因子吸入治療療效觀察. 臨床內科雜志, 2010, 27(3): 168-170.

Chinese Journal of Respiratory and Critical Care Medicine

Therapeutic efficacy of GM-CSF inhalation in patients with recurrent pulmonary alveolar proteinosis

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