Risk Factors for Death in Patients with Bronchiectasis_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

ShengWeili ,  ZhangYongxiang , YinFengxian , ZhaoYing , LiuYanan

Department of Respiratory Medicine, Daxing Hospital of Capital Medical University, Beijing, 102600, China;

Corresponding?author：

ZhangYongxiang, Email: zyx8669@163.com

Keywords：

Bronchiectasis; Risk factors; Prognosis; Mortality

DOI：

10.7507/1671-6205.2016135

Video：

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Objective To explore the risk factors for death in patients with bronchiectasis. Methods Two hundred and eighty-three patients diagnosed with bronchiectasis at Daxing Hospital of Capital Medical University from January 2011 to December 2013 were collected and followed up to October 2015 after discharge. Patients' age, gender, body mass index (BMI), smoking history, dyspnea score, image data, sputum culture, blood gas analysis and the results of spirometry were collected. The risk factors for death were analyzed with COX regression analysis. Results Among 283 cases, 52 patients died. The 1-, 2-, 3-and 4-year cumulative survival rates were 97%, 86%, 71%, 45%, respectively. COX regression analysis showed that age≥70 years (RR=2.222, 95%CI 1.145-4.314), BMI < 18.5 kg/m² (RR=2.328, 95%CI 1.205-4.497), bronchiectasis involving≥3 lobes in chest high-resolution computed tomography (RR=0.382, 95%CI 0.188-0.774) and FEV₁% pred < 70% (RR=1.032, 95%CI 0.923-1.180) were the independent risk factors for death of patients with bronchiectasis (all P < 0.05). Conclusions There are multiple risk factors contribute to death of patients with bronchiectasis. Early identification of risk factors shall improve the prognosis of patients with bronchiectasis.

Citation： ShengWeili, ZhangYongxiang, YinFengxian, ZhaoYing, LiuYanan. Risk Factors for Death in Patients with Bronchiectasis. Chinese Journal of Respiratory and Critical Care Medicine, 2016, 15(6): 593-596. doi: 10.7507/1671-6205.2016135 Copy

1.	成人支氣管擴張癥診治專家共識編寫組.成人支氣管擴張癥診治專家共識.中華結核和呼吸雜志, 2012, 35:485-492.
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4.	Chalmers JD, Goeminne P, Aliberti S, et al. The Bronchiectasis Severity Index an international derivation and validation study. Am J Respir Crit Care Med, 2014, 189:576-585.
5.	Launois C, Barbe C, Bertin E, et al. The modified Medical Research Council scale for the assessment of dyspnea in daily living in obesity:a pilot study. BMC Pulm Med, 2012, 12:61.
6.	WHO Expert Consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet, 2004, 363:157-163.
7.	Quint JK, Millett ER, Joshi M, et al. Changes in the incidence, prevalence and mortality of bronchiectasis in the UK from 2004 to 2013:a population-based cohort study. Eur Respir J, 2016, 47:186-193.
8.	周玉民, 王辰, 姚婉貞, 等.我國7省市城區40歲及以上居民支氣管擴張癥的患病情況及危險因素調查.中華內科雜志, 2013, 52:379-282.
9.	Twiss J, Metcalfe R, Edwards E, et al. New Zealand national incidence of bronchiectasis "too high" for a developed country. Arch Dis Child, 2005, 90:737-740.
10.	Robens HJ, Hubbard R. Trends in bronchiectasis mortality in England and Wales. Respir Med, 2010, 104:981-985.
11.	Onen ZP, Gulbay BE, Sen E, et al. Analysis of the factors related to mortality in patients with bronchiectasis. Respir Med, 2007, 101:1390-1397.
12.	Celli BR, Cote CG, Matin JM, et al. The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease. N Engl J Med, 2004, 350:1005-1012.
13.	焦瑞, 劉雙.支氣管擴張癥急性加重的危險因素及意義.中華醫學雜志, 2015, 95:273-276.
14.	楊慧, 張二明, 郭偉安, 等.老年重度慢性阻塞性肺疾病的預后研究.中國呼吸與危重監護雜志, 2012, 11:213-217.
15.	Hurst JR, Eiborn JS, De Soyza A. BRONCH-UK Consortium. COPD-bronchiectasis overlap syndrome. Eur Respir J, 2015, 45:310-313.
16.	Martínez-García MA, de la Rosa Carrillo D, Soler-Catalu?a JJ, et al. Prognostic value of bronchiectasis in patients with moderate-to-severe chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 2013, 187:823-831.
17.	Pasteur MC, Bilton D, Hill AT; British Thoracic Society Bronchiectasis Non-CF Guideline Group. British Thoracic Society guideline for non-CF bronchiectasis. Thorax, 2010, 65:577-579.
18.	田欣倫, 吳翔, 徐凱峰, 等.成人支氣管擴張患者的病因及臨床特點分析.中國呼吸與危重監護雜志, 2013, 12:576-580.
19.	Maiz L, Vendrell M, Olveira C, et al. Prevalence and factors associated with isolation of Aspergillus and Candida from sputum in patients with non-cystic fibrosis bronchiectasis. Respiration, 2015, 89:396-403.
20.	Goeminne P, Dupont L. Non-cystic fibrosis bronchiectasis:diagnosis and management in 2l st century. Postgrad Med J, 2010, 86:493-501.

1. 成人支氣管擴張癥診治專家共識編寫組.成人支氣管擴張癥診治專家共識.中華結核和呼吸雜志, 2012, 35:485-492.
2. 陸再英, 鐘南山.內科學(第七版).北京:人民衛生出版社, 2008.
3. Minov J, Karadzinska-Bislimovska J, Vasilevska K, et al. Assessment of the non-cystic fibrosis bronchiectasis severity:the FACED score vs the Bronchiectasis Severity Index. Open Respir Med J, 2015, 9:46-51.
4. Chalmers JD, Goeminne P, Aliberti S, et al. The Bronchiectasis Severity Index an international derivation and validation study. Am J Respir Crit Care Med, 2014, 189:576-585.
5. Launois C, Barbe C, Bertin E, et al. The modified Medical Research Council scale for the assessment of dyspnea in daily living in obesity:a pilot study. BMC Pulm Med, 2012, 12:61.
6. WHO Expert Consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet, 2004, 363:157-163.
7. Quint JK, Millett ER, Joshi M, et al. Changes in the incidence, prevalence and mortality of bronchiectasis in the UK from 2004 to 2013:a population-based cohort study. Eur Respir J, 2016, 47:186-193.
8. 周玉民, 王辰, 姚婉貞, 等.我國7省市城區40歲及以上居民支氣管擴張癥的患病情況及危險因素調查.中華內科雜志, 2013, 52:379-282.
9. Twiss J, Metcalfe R, Edwards E, et al. New Zealand national incidence of bronchiectasis "too high" for a developed country. Arch Dis Child, 2005, 90:737-740.
10. Robens HJ, Hubbard R. Trends in bronchiectasis mortality in England and Wales. Respir Med, 2010, 104:981-985.
11. Onen ZP, Gulbay BE, Sen E, et al. Analysis of the factors related to mortality in patients with bronchiectasis. Respir Med, 2007, 101:1390-1397.
12. Celli BR, Cote CG, Matin JM, et al. The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease. N Engl J Med, 2004, 350:1005-1012.
13. 焦瑞, 劉雙.支氣管擴張癥急性加重的危險因素及意義.中華醫學雜志, 2015, 95:273-276.
14. 楊慧, 張二明, 郭偉安, 等.老年重度慢性阻塞性肺疾病的預后研究.中國呼吸與危重監護雜志, 2012, 11:213-217.
15. Hurst JR, Eiborn JS, De Soyza A. BRONCH-UK Consortium. COPD-bronchiectasis overlap syndrome. Eur Respir J, 2015, 45:310-313.
16. Martínez-García MA, de la Rosa Carrillo D, Soler-Catalu?a JJ, et al. Prognostic value of bronchiectasis in patients with moderate-to-severe chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 2013, 187:823-831.
17. Pasteur MC, Bilton D, Hill AT; British Thoracic Society Bronchiectasis Non-CF Guideline Group. British Thoracic Society guideline for non-CF bronchiectasis. Thorax, 2010, 65:577-579.
18. 田欣倫, 吳翔, 徐凱峰, 等.成人支氣管擴張患者的病因及臨床特點分析.中國呼吸與危重監護雜志, 2013, 12:576-580.
19. Maiz L, Vendrell M, Olveira C, et al. Prevalence and factors associated with isolation of Aspergillus and Candida from sputum in patients with non-cystic fibrosis bronchiectasis. Respiration, 2015, 89:396-403.
20. Goeminne P, Dupont L. Non-cystic fibrosis bronchiectasis:diagnosis and management in 2l st century. Postgrad Med J, 2010, 86:493-501.

Chinese Journal of Respiratory and Critical Care Medicine

Risk Factors for Death in Patients with Bronchiectasis

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