自噬在呼吸系統的研究現狀_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

陳延斌 ,  黃建安

蘇州大學附屬第一醫院呼吸與危重癥醫學科（江蘇蘇州 215000）;

Corresponding?author：

黃建安, Email: huang_jian_an@163.com

Keywords：

DOI：

10.7507/1671-6205.201702011

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Citation： 陳延斌, 黃建安. 自噬在呼吸系統的研究現狀. Chinese Journal of Respiratory and Critical Care Medicine, 2017, 16(6): 631-636. doi: 10.7507/1671-6205.201702011 Copy

1.	Nakahira K, Pabon Porras MA, Choi AM. Autophagy in Pulmonary Diseases. Am J Respir Crit Care Med, 2016, 194(10): 1196-1207.
2.	Towers CG, Thorburn A. Therapeutic Targeting of Autophagy. EBioMedicine, 2016. pii: S2352-3964(16)30495-9.
3.	Cadwell K. Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis. Nat Rev Immunol, 2016, 16(11): 661-675.
4.	Shibutani ST, Saitoh T, Nowag H, et al. Autophagy and autophagy-related proteins in the immune system. Nat Immunol, 2015, 16(10): 1014-1024.
5.	Suzuki H, Osawa T, Fujioka Y, et al. Structural biology of the core autophagy machinery. Curr Opin Struct Biol, 2016, 43: 10-17.
6.	Hashimoto S. Autophagy in the respiratory diseases. Respir Investig, 2016, 54(6): 383-384.
7.	Zeki AA, Yeganeh B, Kenyon NJ, et al. Autophagy in airway diseases: a new frontier in human asthma? Allergy, 2016, 71(1): 5-14.
8.	Liu JN, Suh DH, Trinh HK, et al. The role of autophagy in allergic inflammation: a new target for severe asthma. Exp Mol Med, 2016, 48(7): e243.
9.	Farooq MB, Walsh GM. Autophagy and Asthma. Clin Exp Allergy, 2016, 46(1): 7-9.
10.	Pham DL, Ban GY, Kim SH, et al. Neutrophil autophagy and extracellular DNA traps contribute to airway inflammation in severe asthma. Clin Exp Allergy, 2017, 47(1): 57-70.
11.	Poon A, Eidelman D, Laprise C, et al. ATG5, autophagy and lung function in asthma. Autophagy, 2012, 8(4): 694-695.
12.	Martin LJ, Gupta J, Jyothula SS, et al. Functional variant in the autophagy-related 5 gene promotor is associated with childhood asthma. PLoS One, 2012, 7(4): e33454.
13.	Suzuki Y, Maazi H, Sankaranarayanan I, et al. Lack of autophagy induces steroid-resistant airway inflammation. J Allergy Clin Immunol, 2016, 137(5): 1382-1389. e9.
14.	Pham DL, Kim SH, Losol P, et al. Association of autophagy related gene polymorphisms with neutrophilic airway inflammation in adult asthma. Korean J Intern Med, 2016, 31(2): 375-385.
15.	Huang C, Jiang D, Francisco D, et al. Tollip SNP rs5743899 modulates human airway epithelial responses to rhinovirus infection. Clin Exp Allergy, 2016, 46(12): 1549-1563.
16.	Gu W, Cui R, Ding T, et al. Simvastatin alleviates airway inflammation and remodelling through up-regulation of autophagy in mouse models of asthma. Respirology, 2017, 22(3): 533-541.
17.	Lin L, Zhang L, Yu L, et al. Time-dependent changes of autophagy and apoptosis in lipopolysaccharide-induced rat acute lung injury. Iran J Basic Med Sci, 2016, 19(6): 632-637.
18.	Zhou Z, You Z. Mesenchymal Stem Cells Alleviate LPS-Induced Acute Lung Injury in Mice by MiR-142a-5p-Controlled Pulmonary Endothelial Cell Autophagy. Cell Physiol Biochem, 2016, 38(1): 258-266.
19.	Hu Y, Lou J, Mao YY, et al. Activation of MTOR in pulmonary epithelium promotes LPS-induced acute lung injury. Autophagy, 2016, 12(12): 2286-2299.
20.	Carlisle M, Lam A, Svendsen ER, et al. Chlorine-induced cardiopulmonary injury. Ann N Y Acad Sci, 2016, 1374(1): 159-167.
21.	Liu QP, Zhou DX, Sun L, et al. Bone marrow mesenchymal stem cells ameliorates seawater-exposure-induced acute lung injury by inhibiting autophagy in lung tissue. Patholog Res Int, 2014, 2014: 104962.
22.	Zhang Y, Liu G, Dull RO, et al. Autophagy in pulmonary macrophages mediates lung inflammatory injury via NLRP3 inflammasome activation during mechanical ventilation. Am J Physiol Lung Cell Mol Physiol, 2014, 307(2): L173-185.
23.	Sureshbabu A, Syed M, Das P, et al. Inhibition of RPTOR Prevents Hyperoxia-induced Lung Injury by Enhancing Autophagy and Reducing Apoptosis in Neonatal Mice. Am J Respir Cell Mol Biol, 2016, 55(5): 722-735.
24.	Chen CZ, Ou CY, Wang RH, et al. Association of Egr-1 and autophagy-related gene polymorphism in men with chronic obstructive pulmonary disease. J Formos Med Assoc, 2015, 114(8): 750-755.
25.	Hou HH, Cheng SL, Chung KP, et al. Elastase induces lung epithelial cell autophagy through placental growth factor: a new insight of emphysema pathogenesis. Autophagy, 2014, 10(9): 1509-1521.
26.	Kim KH, Song HH, Ahn KS, et al. Ethanol extract of the tuber of Alisma orientale reduces the pathologic features in a chronic obstructive pulmonary disease mouse model. J Ethnopharmacol, 2016, 188: 21-30.
27.	Farré JC, Subramani S. Mechanistic insights into selective autophagy pathways: lessons from yeast. Nat Rev Mol Cell Biol, 2016, 17(9): 537-552.
28.	Cypryk W, Lorey MB, Puustinen A, et al. Proteomic and bioinformatic characterization of extracellular vesicles released from human macrophages upon influenza A virus infection. J Proteome Res, 2017, 16(1): 217-227.
29.	Zang F, Chen Y, Lin Z, et al. Autophagy is involved in regulating the immune response of dendritic cells to influenza A (H1N1) pdm09 infection. Immunology, 2016, 148(1): 56-69.
30.	Gregory DJ, Kobzik L. Influenza lung injury: mechanisms and therapeutic opportunities. Am J Physiol Lung Cell Mol Physiol, 2015, 309(10): L1041-1046.
31.	Pfeiler S, Khandagale AB, Magenau A, et al. Distinct surveillance pathway for immunopathology during acute infection via autophagy and SR-BI. Sci Rep, 2016, 6: 34440.
32.	Deng Q, Wang Y, Zhang Y, et al. Pseudomonas aeruginosa Triggers Macrophage Autophagy To Escape Intracellular Killing by Activation of the NLRP3 Inflammasome. Infect Immun, 2015, 84(1): 56-66.
33.	Neumann Y, Bruns SA, Rohde M, et al. Intracellular Staphylococcus aureus eludes selective autophagy by activating a host cell kinase. Autophagy, 2016, 12(11): 2069-2084.
34.	O'Neill AM, Thurston TL, Holden DW. Cytosolic Replication of Group A Streptococcus in Human Macrophages. MBio, 2016, 7(2): e00020-16.
35.	Wang Y, Zhang K, Shi X, et al. Critical role of bacterial isochorismatase in the autophagic process induced by Acinetobacter baumannii in mammalian cells. FASEB J, 2016, 30(10): 3563-3577.
36.	Oliveira DL, Fonseca FL, Zamith-Miranda D, et al. The putative autophagy regulator Atg7 affects the physiology and pathogenic mechanisms of Cryptococcus neoformans. Future Microbiol, 2016, 11: 1405-1419.
37.	Zhang L, Ai Y, Tsung A. Clinical application: Restoration of immune homeostasis by autophagy as a potential therapeutic target in sepsis. Exp Ther Med, 2016, 11(4): 1159-1167.
38.	Ho J, Yu J, Wong SH, et al. Autophagy in sepsis: Degradation into exhaustion? Autophagy, 2016, 12(7): 1073-1082.
39.	Liu YW, Yang T, Zhao L, et al. Activation of Adenosine 2A receptor inhibits neutrophil apoptosis in an autophagy-dependent manner in mice with systemic inflammatory response syndrome. Sci Rep, 2016, 6: 33614.
40.	O'Dwyer DN, Ashley SL, Moore BB. Influences of innate immunity, autophagy, and fibroblast activation in the pathogenesis of lung fibrosis. Am J Physiol Lung Cell Mol Physiol, 2016, 311(3): L590-601.
41.	Kobayashi K, Araya J, Minagawa S, et al. Involvement of PARK2-Mediated Mitophagy in Idiopathic Pulmonary Fibrosis Pathogenesis. J Immunol, 2016, 197(2): 504-516.
42.	Larson-Casey JL, Deshane JS, Ryan AJ, et al. Macrophage Akt1 Kinase-Mediated Mitophagy Modulates Apoptosis Resistance and Pulmonary Fibrosis. Immunity, 2016, 44(3): 582-596.
43.	Rangarajan S, Kurundkar A, Kurundkar D, et al. Novel Mechanisms for the Antifibrotic Action of Nintedanib. Am J Respir Cell Mol Biol, 2016, 54(1): 51-59.
44.	Lin L, Baehrecke EH. Autophagy, cell death, and cancer. Mol Cell Oncol, 2015, 2(3): e985913.
45.	Gewirtz DA. The Challenge of Developing Autophagy Inhibition as a Therapeutic Strategy. Cancer Res, 2016, 76(19): 5610-5614.
46.	Chen T, Ren H, Thakur A, et al. Decreased Level of Klotho Contributes to Drug Resistance in Lung Cancer Cells: Involving in Klotho-Mediated Cell Autophagy. DNA Cell Biol, 2016, 35(12): 751-757.
47.	Yu XS, Du J, Fan YJ, et al. Activation of endoplasmic reticulum stress promotes autophagy and apoptosis and reverses chemoresistance of human small cell lung cancer cells by inhibiting the PI3K/AKT/mTOR signaling pathway. Oncotarget, 2016, 7(47): 76827-76839.
48.	Min YH, Kim W, Kim JE. The Aurora kinase A inhibitor TC-A2317 disrupts mitotic progression and inhibits cancer cell proliferation. Oncotarget, 2016, 7(51): 84718-84735.
49.	Brisson L, Bański P, Sboarina M, et al. Lactate Dehydrogenase B Controls Lysosome Activity and Autophagy in Cancer. Cancer Cell, 2016, 30(3): 418-431.
50.	Nazim UM, Moon JH, Lee JH, et al. Activation of autophagy flux by metformin downregulates cellular FLICE-like inhibitory protein and enhances TRAIL-induced apoptosis. Oncotarget, 2016, 7(17): 23468-23481.
51.	Schl?fli AM, Adams O, Galván JA, et al. Prognostic value of the autophagy markers LC3 and p62/SQSTM1 in early-stage non-small cell lung cancer. Oncotarget, 2016, 7(26): 39544-39555.
52.	Xie K, Liang C, Li Q, et al. Role of ATG10 expression quantitative trait loci in non-small cell lung cancer survival. Int J Cancer, 2016, 139(7): 1564-1573.
53.	Wu HM, Shao LJ, Jiang ZF, et al. Gemcitabine-Induced Autophagy Protects Human Lung Cancer Cells from Apoptotic Death. Lung, 2016, 194(6): 959-966.
54.	Chen K, Shi W. Autophagy regulates resistance of non-small cell lung cancer cells to paclitaxel. Tumour Biol, 2016, 37(8): 10539-10544.
55.	Zhao ZQ, Yu ZY, Li J, et al. Gefitinib induces lung cancer cell autophagy and apoptosis via blockade of the PI3K/AKT/mTOR pathway. Oncol Lett, 2016, 12(1): 63-68.
56.	Li XQ, Liu JT, Fan LL, et al. Exosomes derived from gefitinib-treated EGFR-mutant lung cancer cells alter cisplatin sensitivity via up-regulating autophagy. Oncotarget, 2016, 7(17): 24585-24595.
57.	Wang Z, Du T, Dong X, et al. Autophagy inhibition facilitates erlotinib cytotoxicity in lung cancer cells through modulation of endoplasmic reticulum stress. Int J Oncol, 2016, 48(6): 2558-2566.
58.	Fei HR, Tian H, Zhou XL, et al. Inhibition of autophagy enhances effects of PF-04691502 on apoptosis and DNA damage of lung cancer cells. Int J Biochem Cell Biol, 2016, 78(1): 52-62.
59.	Jin HO, Hong SE, Park JA, et al. Inhibition of JNK-mediated autophagy enhances NSCLC cell sensitivity to mTORC1/2 inhibitors. Sci Rep, 2016, 6(1): 28945.
60.	Tan Q, Wang M, Yu M, et al. Role of Autophagy as a Survival Mechanism for Hypoxic Cells in Tumors. Neoplasia, 2016, 18(6): 347-355.
61.	Guo JY, Teng X, Laddha SV, et al. Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells. Genes Dev, 2016, 30(15): 1704-1717.
62.	Sharifi MN, Mowers EE, Drake LE, et al. Autophagy Promotes Focal Adhesion Disassembly and Cell Motility of Metastatic Tumor Cells through the Direct Interaction of Paxillin with LC3. Cell Rep, 2016, 15(8): 1660-1672.
63.	Parker AL, Turner N, McCarroll JA, et al. βIII-Tubulin alters glucose metabolism and stress response signaling to promote cell survival and proliferation in glucose-starved non-small cell lung cancer cells. Carcinogenesis, 2016, 37(8): 787-798.
64.	Li L, Wang X, Wang L, et al. Mammalian target of rapamycin overexpression antagonizes chronic hypoxia-triggered pulmonary arterial hypertension via the autophagic pathway. Int J Mol Med, 2015, 36(1): 316-322.
65.	Dalvi P, Sharma H, Chinnappan M, et al. Enhanced autophagy in pulmonary endothelial cells on exposure to HIV-Tat and morphine: Role in HIV-related pulmonary arterial hypertension. Autophagy, 2016, 12(12): 2420-2438.
66.	Singh N, Manhas A, Kaur G, et al. Inhibition of fatty acid synthase is protective in pulmonary hypertension. Br J Pharmacol, 2016, 173(12): 2030-2045.
67.	Lahm T, Frump AL, Albrecht ME, et al. 17β-Estradiol mediates superior adaptation of right ventricular function to acute strenuous exercise in female rats with severe pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol, 2016, 311(2): L375-388.
68.	Wang X, Ibrahim YF, Das D, et al. Carfilzomib reverses pulmonary arterial hypertension. Cardiovasc Res, 2016, 110(2): 188-199.

1. Nakahira K, Pabon Porras MA, Choi AM. Autophagy in Pulmonary Diseases. Am J Respir Crit Care Med, 2016, 194(10): 1196-1207.
2. Towers CG, Thorburn A. Therapeutic Targeting of Autophagy. EBioMedicine, 2016. pii: S2352-3964(16)30495-9.
3. Cadwell K. Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis. Nat Rev Immunol, 2016, 16(11): 661-675.
4. Shibutani ST, Saitoh T, Nowag H, et al. Autophagy and autophagy-related proteins in the immune system. Nat Immunol, 2015, 16(10): 1014-1024.
5. Suzuki H, Osawa T, Fujioka Y, et al. Structural biology of the core autophagy machinery. Curr Opin Struct Biol, 2016, 43: 10-17.
6. Hashimoto S. Autophagy in the respiratory diseases. Respir Investig, 2016, 54(6): 383-384.
7. Zeki AA, Yeganeh B, Kenyon NJ, et al. Autophagy in airway diseases: a new frontier in human asthma? Allergy, 2016, 71(1): 5-14.
8. Liu JN, Suh DH, Trinh HK, et al. The role of autophagy in allergic inflammation: a new target for severe asthma. Exp Mol Med, 2016, 48(7): e243.
9. Farooq MB, Walsh GM. Autophagy and Asthma. Clin Exp Allergy, 2016, 46(1): 7-9.
10. Pham DL, Ban GY, Kim SH, et al. Neutrophil autophagy and extracellular DNA traps contribute to airway inflammation in severe asthma. Clin Exp Allergy, 2017, 47(1): 57-70.
11. Poon A, Eidelman D, Laprise C, et al. ATG5, autophagy and lung function in asthma. Autophagy, 2012, 8(4): 694-695.
12. Martin LJ, Gupta J, Jyothula SS, et al. Functional variant in the autophagy-related 5 gene promotor is associated with childhood asthma. PLoS One, 2012, 7(4): e33454.
13. Suzuki Y, Maazi H, Sankaranarayanan I, et al. Lack of autophagy induces steroid-resistant airway inflammation. J Allergy Clin Immunol, 2016, 137(5): 1382-1389. e9.
14. Pham DL, Kim SH, Losol P, et al. Association of autophagy related gene polymorphisms with neutrophilic airway inflammation in adult asthma. Korean J Intern Med, 2016, 31(2): 375-385.
15. Huang C, Jiang D, Francisco D, et al. Tollip SNP rs5743899 modulates human airway epithelial responses to rhinovirus infection. Clin Exp Allergy, 2016, 46(12): 1549-1563.
16. Gu W, Cui R, Ding T, et al. Simvastatin alleviates airway inflammation and remodelling through up-regulation of autophagy in mouse models of asthma. Respirology, 2017, 22(3): 533-541.
17. Lin L, Zhang L, Yu L, et al. Time-dependent changes of autophagy and apoptosis in lipopolysaccharide-induced rat acute lung injury. Iran J Basic Med Sci, 2016, 19(6): 632-637.
18. Zhou Z, You Z. Mesenchymal Stem Cells Alleviate LPS-Induced Acute Lung Injury in Mice by MiR-142a-5p-Controlled Pulmonary Endothelial Cell Autophagy. Cell Physiol Biochem, 2016, 38(1): 258-266.
19. Hu Y, Lou J, Mao YY, et al. Activation of MTOR in pulmonary epithelium promotes LPS-induced acute lung injury. Autophagy, 2016, 12(12): 2286-2299.
20. Carlisle M, Lam A, Svendsen ER, et al. Chlorine-induced cardiopulmonary injury. Ann N Y Acad Sci, 2016, 1374(1): 159-167.
21. Liu QP, Zhou DX, Sun L, et al. Bone marrow mesenchymal stem cells ameliorates seawater-exposure-induced acute lung injury by inhibiting autophagy in lung tissue. Patholog Res Int, 2014, 2014: 104962.
22. Zhang Y, Liu G, Dull RO, et al. Autophagy in pulmonary macrophages mediates lung inflammatory injury via NLRP3 inflammasome activation during mechanical ventilation. Am J Physiol Lung Cell Mol Physiol, 2014, 307(2): L173-185.
23. Sureshbabu A, Syed M, Das P, et al. Inhibition of RPTOR Prevents Hyperoxia-induced Lung Injury by Enhancing Autophagy and Reducing Apoptosis in Neonatal Mice. Am J Respir Cell Mol Biol, 2016, 55(5): 722-735.
24. Chen CZ, Ou CY, Wang RH, et al. Association of Egr-1 and autophagy-related gene polymorphism in men with chronic obstructive pulmonary disease. J Formos Med Assoc, 2015, 114(8): 750-755.
25. Hou HH, Cheng SL, Chung KP, et al. Elastase induces lung epithelial cell autophagy through placental growth factor: a new insight of emphysema pathogenesis. Autophagy, 2014, 10(9): 1509-1521.
26. Kim KH, Song HH, Ahn KS, et al. Ethanol extract of the tuber of Alisma orientale reduces the pathologic features in a chronic obstructive pulmonary disease mouse model. J Ethnopharmacol, 2016, 188: 21-30.
27. Farré JC, Subramani S. Mechanistic insights into selective autophagy pathways: lessons from yeast. Nat Rev Mol Cell Biol, 2016, 17(9): 537-552.
28. Cypryk W, Lorey MB, Puustinen A, et al. Proteomic and bioinformatic characterization of extracellular vesicles released from human macrophages upon influenza A virus infection. J Proteome Res, 2017, 16(1): 217-227.
29. Zang F, Chen Y, Lin Z, et al. Autophagy is involved in regulating the immune response of dendritic cells to influenza A (H1N1) pdm09 infection. Immunology, 2016, 148(1): 56-69.
30. Gregory DJ, Kobzik L. Influenza lung injury: mechanisms and therapeutic opportunities. Am J Physiol Lung Cell Mol Physiol, 2015, 309(10): L1041-1046.
31. Pfeiler S, Khandagale AB, Magenau A, et al. Distinct surveillance pathway for immunopathology during acute infection via autophagy and SR-BI. Sci Rep, 2016, 6: 34440.
32. Deng Q, Wang Y, Zhang Y, et al. Pseudomonas aeruginosa Triggers Macrophage Autophagy To Escape Intracellular Killing by Activation of the NLRP3 Inflammasome. Infect Immun, 2015, 84(1): 56-66.
33. Neumann Y, Bruns SA, Rohde M, et al. Intracellular Staphylococcus aureus eludes selective autophagy by activating a host cell kinase. Autophagy, 2016, 12(11): 2069-2084.
34. O'Neill AM, Thurston TL, Holden DW. Cytosolic Replication of Group A Streptococcus in Human Macrophages. MBio, 2016, 7(2): e00020-16.
35. Wang Y, Zhang K, Shi X, et al. Critical role of bacterial isochorismatase in the autophagic process induced by Acinetobacter baumannii in mammalian cells. FASEB J, 2016, 30(10): 3563-3577.
36. Oliveira DL, Fonseca FL, Zamith-Miranda D, et al. The putative autophagy regulator Atg7 affects the physiology and pathogenic mechanisms of Cryptococcus neoformans. Future Microbiol, 2016, 11: 1405-1419.
37. Zhang L, Ai Y, Tsung A. Clinical application: Restoration of immune homeostasis by autophagy as a potential therapeutic target in sepsis. Exp Ther Med, 2016, 11(4): 1159-1167.
38. Ho J, Yu J, Wong SH, et al. Autophagy in sepsis: Degradation into exhaustion? Autophagy, 2016, 12(7): 1073-1082.
39. Liu YW, Yang T, Zhao L, et al. Activation of Adenosine 2A receptor inhibits neutrophil apoptosis in an autophagy-dependent manner in mice with systemic inflammatory response syndrome. Sci Rep, 2016, 6: 33614.
40. O'Dwyer DN, Ashley SL, Moore BB. Influences of innate immunity, autophagy, and fibroblast activation in the pathogenesis of lung fibrosis. Am J Physiol Lung Cell Mol Physiol, 2016, 311(3): L590-601.
41. Kobayashi K, Araya J, Minagawa S, et al. Involvement of PARK2-Mediated Mitophagy in Idiopathic Pulmonary Fibrosis Pathogenesis. J Immunol, 2016, 197(2): 504-516.
42. Larson-Casey JL, Deshane JS, Ryan AJ, et al. Macrophage Akt1 Kinase-Mediated Mitophagy Modulates Apoptosis Resistance and Pulmonary Fibrosis. Immunity, 2016, 44(3): 582-596.
43. Rangarajan S, Kurundkar A, Kurundkar D, et al. Novel Mechanisms for the Antifibrotic Action of Nintedanib. Am J Respir Cell Mol Biol, 2016, 54(1): 51-59.
44. Lin L, Baehrecke EH. Autophagy, cell death, and cancer. Mol Cell Oncol, 2015, 2(3): e985913.
45. Gewirtz DA. The Challenge of Developing Autophagy Inhibition as a Therapeutic Strategy. Cancer Res, 2016, 76(19): 5610-5614.
46. Chen T, Ren H, Thakur A, et al. Decreased Level of Klotho Contributes to Drug Resistance in Lung Cancer Cells: Involving in Klotho-Mediated Cell Autophagy. DNA Cell Biol, 2016, 35(12): 751-757.
47. Yu XS, Du J, Fan YJ, et al. Activation of endoplasmic reticulum stress promotes autophagy and apoptosis and reverses chemoresistance of human small cell lung cancer cells by inhibiting the PI3K/AKT/mTOR signaling pathway. Oncotarget, 2016, 7(47): 76827-76839.
48. Min YH, Kim W, Kim JE. The Aurora kinase A inhibitor TC-A2317 disrupts mitotic progression and inhibits cancer cell proliferation. Oncotarget, 2016, 7(51): 84718-84735.
49. Brisson L, Bański P, Sboarina M, et al. Lactate Dehydrogenase B Controls Lysosome Activity and Autophagy in Cancer. Cancer Cell, 2016, 30(3): 418-431.
50. Nazim UM, Moon JH, Lee JH, et al. Activation of autophagy flux by metformin downregulates cellular FLICE-like inhibitory protein and enhances TRAIL-induced apoptosis. Oncotarget, 2016, 7(17): 23468-23481.
51. Schl?fli AM, Adams O, Galván JA, et al. Prognostic value of the autophagy markers LC3 and p62/SQSTM1 in early-stage non-small cell lung cancer. Oncotarget, 2016, 7(26): 39544-39555.
52. Xie K, Liang C, Li Q, et al. Role of ATG10 expression quantitative trait loci in non-small cell lung cancer survival. Int J Cancer, 2016, 139(7): 1564-1573.
53. Wu HM, Shao LJ, Jiang ZF, et al. Gemcitabine-Induced Autophagy Protects Human Lung Cancer Cells from Apoptotic Death. Lung, 2016, 194(6): 959-966.
54. Chen K, Shi W. Autophagy regulates resistance of non-small cell lung cancer cells to paclitaxel. Tumour Biol, 2016, 37(8): 10539-10544.
55. Zhao ZQ, Yu ZY, Li J, et al. Gefitinib induces lung cancer cell autophagy and apoptosis via blockade of the PI3K/AKT/mTOR pathway. Oncol Lett, 2016, 12(1): 63-68.
56. Li XQ, Liu JT, Fan LL, et al. Exosomes derived from gefitinib-treated EGFR-mutant lung cancer cells alter cisplatin sensitivity via up-regulating autophagy. Oncotarget, 2016, 7(17): 24585-24595.
57. Wang Z, Du T, Dong X, et al. Autophagy inhibition facilitates erlotinib cytotoxicity in lung cancer cells through modulation of endoplasmic reticulum stress. Int J Oncol, 2016, 48(6): 2558-2566.
58. Fei HR, Tian H, Zhou XL, et al. Inhibition of autophagy enhances effects of PF-04691502 on apoptosis and DNA damage of lung cancer cells. Int J Biochem Cell Biol, 2016, 78(1): 52-62.
59. Jin HO, Hong SE, Park JA, et al. Inhibition of JNK-mediated autophagy enhances NSCLC cell sensitivity to mTORC1/2 inhibitors. Sci Rep, 2016, 6(1): 28945.
60. Tan Q, Wang M, Yu M, et al. Role of Autophagy as a Survival Mechanism for Hypoxic Cells in Tumors. Neoplasia, 2016, 18(6): 347-355.
61. Guo JY, Teng X, Laddha SV, et al. Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells. Genes Dev, 2016, 30(15): 1704-1717.
62. Sharifi MN, Mowers EE, Drake LE, et al. Autophagy Promotes Focal Adhesion Disassembly and Cell Motility of Metastatic Tumor Cells through the Direct Interaction of Paxillin with LC3. Cell Rep, 2016, 15(8): 1660-1672.
63. Parker AL, Turner N, McCarroll JA, et al. βIII-Tubulin alters glucose metabolism and stress response signaling to promote cell survival and proliferation in glucose-starved non-small cell lung cancer cells. Carcinogenesis, 2016, 37(8): 787-798.
64. Li L, Wang X, Wang L, et al. Mammalian target of rapamycin overexpression antagonizes chronic hypoxia-triggered pulmonary arterial hypertension via the autophagic pathway. Int J Mol Med, 2015, 36(1): 316-322.
65. Dalvi P, Sharma H, Chinnappan M, et al. Enhanced autophagy in pulmonary endothelial cells on exposure to HIV-Tat and morphine: Role in HIV-related pulmonary arterial hypertension. Autophagy, 2016, 12(12): 2420-2438.
66. Singh N, Manhas A, Kaur G, et al. Inhibition of fatty acid synthase is protective in pulmonary hypertension. Br J Pharmacol, 2016, 173(12): 2030-2045.
67. Lahm T, Frump AL, Albrecht ME, et al. 17β-Estradiol mediates superior adaptation of right ventricular function to acute strenuous exercise in female rats with severe pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol, 2016, 311(2): L375-388.
68. Wang X, Ibrahim YF, Das D, et al. Carfilzomib reverses pulmonary arterial hypertension. Cardiovasc Res, 2016, 110(2): 188-199.

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自噬在呼吸系統的研究現狀

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