The correlation of serum 8-hydroxydeoxyguanosine and endothelin-1 levels with cognitive dysfunction in COPD patients_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

ZHU Xiaoying ¹ , LIU Conghui ² ,  GE Yanlei ¹ , WANG Hongyang ¹ , CHEN Qiancheng ¹ , ZHANG Ci ¹ , LI Hongli ¹ , ZHANG Jiabin ¹ , WANG Yuan ¹

1. Department of Respiratory Medicine, Affiliated Hospital of North China University of Science and Technology, Tangshan, Hebei 063000, P. R. China;
2. Department of Endocrinology, Affiliated Hospital of North China University of Science and Technology, Tangshan, Hebei 063000, P. R. China;

Corresponding?author：

GE Yanlei, Email: 495732196@qq.com

Keywords：

Chronic obstructive pulmonary disease; Cognitive function; Montreal cognitive assessment; 8-hydroxydeoxyguanosine; Endothelin-1

DOI：

10.7507/1671-6205.201805068

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Objective To investigate the correlation and clinical significance of 8-hydroxydeoxyguanosine (8-OHdG) and endothelin-1 (ET-1) levels with cognitive dysfunction in patients with chronic obstructive pulmonary disease (COPD), and provide new idea for the prevention and treatment for cognitive dysfunction in COPD patients.Methods A total of 103 COPD patients, according to the Montreal cognitive assessment scale standard for evaluation, were divided into a cognitive dysfunction group and a cognitive normal group. Serum 8-OHdG and ET-1 levels were compared between the two groups and their correlations with cognitive function were analyzed with the receiver operating characteristic (ROC) curve.Results The levels of serum 8-OHdG and ET-1 in the COPD patients with cognitive impairment were significantly higher than those in the cognitive normal group ［8-OHdG: (13.91±9.04) ng/ml vs. (7.28±3.00) ng/ml; ET-1: (95.64±57.66)pg/ml vs. (69.20±7.89)pg/ml］ (both P<0.05). The levels of 8-OHdG (OR=22.94, 95%CI 7.06-74.53) and ET-1 (OR=19.76, 95%CI 6.59-59.31) were associated with cognitive impairment in the COPD patients. The areas under ROC curve of serum 8-OHdG and ET-1 levels to predict cognitive dysfunction in the COPD patients were 0.786 (95%CI 0.691-0.881) and 0.790(95%CI 0.695-0.885).Conclusions The serum levels of 8-OHdG and ET-1 are associated with cognitive impairment in COPD patients. The levels of 8-OHdG and ET-1 in serum can predict cognitive impairment with high specificity.

Citation： ZHU Xiaoying, LIU Conghui, GE Yanlei, WANG Hongyang, CHEN Qiancheng, ZHANG Ci, LI Hongli, ZHANG Jiabin, WANG Yuan. The correlation of serum 8-hydroxydeoxyguanosine and endothelin-1 levels with cognitive dysfunction in COPD patients. Chinese Journal of Respiratory and Critical Care Medicine, 2019, 18(1): 10-14. doi: 10.7507/1671-6205.201805068 Copy

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3.	李美珠. 血清 8-羥基脫氧鳥苷酸在急性腦梗死診斷中的應用. 廣東醫學, 2015, 36(20): 3191-3193.
4.	Wauters A, Dreyfuss C, Pochet S, et al. Acute exposure to diesel exhaust impairs nitric oxide-mediated endothelial vasomotor function by increasing endothelial oxidativestress. Hypertension, 2013, 62(2): 352-358.
5.	洪麗, 趙燕民, 李珂. 血清尿酸及血管內皮素-1 與輕度認知功能障礙相關性研究. 中華實用診斷與治療雜志, 2013, 27(7): 670-672.
6.	郭炳鵬, 周露茜, 關力理, 等. 慢性阻塞性肺疾病呼吸康復與炎癥反應及氧化應激的研究進展. 中華結核和呼吸雜志, 2017, 40(12): 15-17.
7.	蔣雪蓮, 鐘萍, 黃成亮, 等. 氧化應激反應標記物對慢性阻塞性肺疾病穩定期患者血清中的表達及意義. 中國呼吸與危重監護雜志, 2016, 15(6): 542-547.
8.	Li JH, Fei GH. The evaluation of cognitive impairment and relevant factors in patients with chronic obstructive pulmonary disease. Respiration, 2013, 85(2): 98-105.
9.	Milnerowicz H, ?ciskalska M, Dul M. Molecular mechanisms of the impact of smoke-oxidants. Exp Toxicol Pathol, 2015, 67(7-8): 377-382.
10.	Dodd JW, Getov SV, Jones PW. Cognitive function in COPD. Eur Respir J, 2010, 35(4): 913-922.
11.	Valavanidis A, Vlachogianni T, Fiotakis C, et al. 8-hydroxy-2'-deoxyguanosine (8-OHdG): a critical biomarker of oxidative stress and carcinogenesis. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev, 2009, 27(2): 120-139.
12.	Nakajima H, Unoda K, Ito T, et al. The relation of urinary 8-OHdG, a marker of oxidative stress to DNA, and clinical outcomes for ischemic stroke. Open Neurol J, 2012, 6: 51-57.
13.	蘇恩勇, 高傳玉. 內皮功能障礙與心血管疾病關系的研究進展. 中華實用診斷與治療雜志, 2018, 32(6): 622-624.
14.	Spiropoulos K, Trakada G, Nikolaou E, et al. Endothelin-1 levels in the pathophysiology of chronic obstructive pulmonary disease and bronchial asthma. Respir Med, 2003, 97(8): 983-989.
15.	Vanhoutte PM, Shimokawa H, Feletou M, et al. Endothelial dysfunction and vascular a disease: a 30th anniversary update. Acta Physiol (Ocf), 2017, 219(1): 22-96.
16.	Briyal S, Philip T, Gulati A. Endothelin-A receptor antagonists prevent amyloid-beta-induced increase in ETA receptor expression, oxidative stress and cognitive impairment. J Alzheimers Dis, 2011, 23(3): 491-503.
17.	張魁, 田文靜, 朱云亮, 等. 依那普利治療老年腦血栓患者的療效及其對內皮素-1 和超氧化物歧化酶水平的影響. 疑難病雜志, 2016, 15(6): 563-566.

1. 蔡柏薔. 慢性阻塞性肺疾病診斷、處理和預防全球策略 (2017 GOLD 報告) 解讀. 國際呼吸雜志, 2017, 37(1): 6-17.
2. 中華醫學會呼吸學分會慢性阻塞性肺疾病學組. 慢性阻塞性肺疾病診治指南 (2007 修訂版). 中華結核和呼吸雜志, 2007, 30(1): 8-17.
3. 李美珠. 血清 8-羥基脫氧鳥苷酸在急性腦梗死診斷中的應用. 廣東醫學, 2015, 36(20): 3191-3193.
4. Wauters A, Dreyfuss C, Pochet S, et al. Acute exposure to diesel exhaust impairs nitric oxide-mediated endothelial vasomotor function by increasing endothelial oxidativestress. Hypertension, 2013, 62(2): 352-358.
5. 洪麗, 趙燕民, 李珂. 血清尿酸及血管內皮素-1 與輕度認知功能障礙相關性研究. 中華實用診斷與治療雜志, 2013, 27(7): 670-672.
6. 郭炳鵬, 周露茜, 關力理, 等. 慢性阻塞性肺疾病呼吸康復與炎癥反應及氧化應激的研究進展. 中華結核和呼吸雜志, 2017, 40(12): 15-17.
7. 蔣雪蓮, 鐘萍, 黃成亮, 等. 氧化應激反應標記物對慢性阻塞性肺疾病穩定期患者血清中的表達及意義. 中國呼吸與危重監護雜志, 2016, 15(6): 542-547.
8. Li JH, Fei GH. The evaluation of cognitive impairment and relevant factors in patients with chronic obstructive pulmonary disease. Respiration, 2013, 85(2): 98-105.
9. Milnerowicz H, ?ciskalska M, Dul M. Molecular mechanisms of the impact of smoke-oxidants. Exp Toxicol Pathol, 2015, 67(7-8): 377-382.
10. Dodd JW, Getov SV, Jones PW. Cognitive function in COPD. Eur Respir J, 2010, 35(4): 913-922.
11. Valavanidis A, Vlachogianni T, Fiotakis C, et al. 8-hydroxy-2'-deoxyguanosine (8-OHdG): a critical biomarker of oxidative stress and carcinogenesis. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev, 2009, 27(2): 120-139.
12. Nakajima H, Unoda K, Ito T, et al. The relation of urinary 8-OHdG, a marker of oxidative stress to DNA, and clinical outcomes for ischemic stroke. Open Neurol J, 2012, 6: 51-57.
13. 蘇恩勇, 高傳玉. 內皮功能障礙與心血管疾病關系的研究進展. 中華實用診斷與治療雜志, 2018, 32(6): 622-624.
14. Spiropoulos K, Trakada G, Nikolaou E, et al. Endothelin-1 levels in the pathophysiology of chronic obstructive pulmonary disease and bronchial asthma. Respir Med, 2003, 97(8): 983-989.
15. Vanhoutte PM, Shimokawa H, Feletou M, et al. Endothelial dysfunction and vascular a disease: a 30th anniversary update. Acta Physiol (Ocf), 2017, 219(1): 22-96.
16. Briyal S, Philip T, Gulati A. Endothelin-A receptor antagonists prevent amyloid-beta-induced increase in ETA receptor expression, oxidative stress and cognitive impairment. J Alzheimers Dis, 2011, 23(3): 491-503.
17. 張魁, 田文靜, 朱云亮, 等. 依那普利治療老年腦血栓患者的療效及其對內皮素-1 和超氧化物歧化酶水平的影響. 疑難病雜志, 2016, 15(6): 563-566.

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The correlation of serum 8-hydroxydeoxyguanosine and endothelin-1 levels with cognitive dysfunction in COPD patients

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