Clinical characteristics of amyopathic dermatomyositis with organizing pneumonia_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

LI Xueren , PENG Shouchun , WANG Liping ,  LIU Bin

Department of Respiratory and Critical Care Medicine, Medical Center of Chinese People’s Armed Police Force, Tianjing 300162, P. R. China;

Corresponding?author：

LIU Bin, Email: 13820931847@163.com

Keywords：

Amyopathic dermatomyositis with organizing pneumonia; Cryptogenic organizing pneumonia; Chest CT; Pulmonary function testing

DOI：

10.7507/1671-6205.201810011

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Objective To analyze the clinical characteristics of patients with amyopathic dermatomyositis with organizing pneumonia (ADM-OP).Methods The clinical data of 8 patients hospitalized with ADM-OP from June 2014 to June 2018 were retrospectively reviewed and simultaneously compared with those of 8 patients of cryptogenic organizing pneumonia (COP).Results The incidence of skin lesion, Gottron’s sign, mechanic’s hand and positive anti-synthase antibodies in the ADM-OP patients were 87.5%, 87.5% 75.0% and 87.5% respectively. Gender, smoking, respiratory symptoms and signs, arterial partial pressure of oxygen, arterial partial pressure of carbon dioxide and treatment strategy were no statistical difference between ADM-OP and COP patients, but the onset age and Chest CT fibrosis scores (CTFS) on admission existed differences. After treatment for 3 months, CTFS, rate of change and forced vital capacity (FVC) existed differences. After treatment for 6 months, CTFS, rate of change, FVC and diffusing capacity of the lung for carbon monoxide existed differences.Conclusions Skin lesion, Gottron’s sign, mechanic’s hand and positive anti-synthase antibodies are more common in ADM-OP patients. Their response to treatment is good but the improvement rates in CTFS and pulmonary function are slower than those of COP patients.

Citation： LI Xueren, PENG Shouchun, WANG Liping, LIU Bin. Clinical characteristics of amyopathic dermatomyositis with organizing pneumonia. Chinese Journal of Respiratory and Critical Care Medicine, 2019, 18(2): 140-143. doi: 10.7507/1671-6205.201810011 Copy

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8.	Lynch DA, Godwin JD, Safrin S, et al. High-resolution computed tomography in idiopathic pulmonary fibrosis: diagnosis and prognosis. Am J Respir Crit Care Med, 2005, 172(4): 488-493.
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10.	董馨, 鄭毅, 王麗, 等. 結締組織病相關性機化性肺炎的臨床特點. 中華風濕病學雜志, 2015, 19(6): 374-379.
11.	沈敏, 龔瑜林, 曾小峰, 等. 以間質性肺疾病起病的皮肌炎臨床特點分析. 中華醫學雜志, 2014, 94(43): 3402-3406.
12.	Hayashi S, Tanaka M, Kobayashi H, et al. High-resolution computed tomography characterization of interstitial lung diseases in polymyositis/dermatomyositis. J Rheumatol, 2008, 35(2): 260-269.
13.	Tsuchiya Y, Fischer A, Solomon JJ, et al. Connective tissue disease-related thoracic disease. Clin Chest Med, 2015, 36(2): 283-297.

1. Sontheimer RD. Cutaneous features of classic dermatomyositis and amyopathic dermatomyositis. Curr Opin Rheumatol, 1999, 11(6): 475-482.
2. 韓磊, 呂良敬. 無肌病性皮肌炎的研究進展. 中華風濕病學雜志, 2011, 15(11): 795-797.
3. Sun Y, Liu Y, Yan B, et al. Interstitial lung disease in clinically amyopathic dermatomyositis (CADM) patients: a retrospective study of 41 Chinese Han patients. Rheumatol Int, 2013, 33(5): 1295-1302.
4. Li XR, Peng SC, Wei LQ. Nonspecific interstitial pneumonia overlaps organizing pneumonia in lung-dominant connective tissue disease. Int J Clin Exp Pathol, 2015, 8(9): 11230-11235.
5. 中華醫學會風濕病學分會. 多發性肌炎和皮肌炎診斷及治療指南. 中華風濕病學雜志, 2010, 14(12): 828-831.
6. Bradley B, Branley HM, Egan JJ, et al. Interstitial Lung Disease Guideline: the British Thoracic Society in Collaboration with the Thoracic Society of Australia and New Zealand and the Irish Thoracic Society. Thorax, 2008, 63(Suppl 5): v1-v58.
7. Travis WD, Costabel U, Hansell DM, et al. An official American Thoracic Society/European Respiratory Society Statement: Update of the International Multidisciplinary Classification of the Idiopathic Interstitial Pneumonias. Am J Respir Crit Care Med, 2013, 188(6): 733-748.
8. Lynch DA, Godwin JD, Safrin S, et al. High-resolution computed tomography in idiopathic pulmonary fibrosis: diagnosis and prognosis. Am J Respir Crit Care Med, 2005, 172(4): 488-493.
9. 徐凌, 沈策. 機化性肺炎的研究進展. 國際呼吸雜志, 2007, 27(24): 1903-1906.
10. 董馨, 鄭毅, 王麗, 等. 結締組織病相關性機化性肺炎的臨床特點. 中華風濕病學雜志, 2015, 19(6): 374-379.
11. 沈敏, 龔瑜林, 曾小峰, 等. 以間質性肺疾病起病的皮肌炎臨床特點分析. 中華醫學雜志, 2014, 94(43): 3402-3406.
12. Hayashi S, Tanaka M, Kobayashi H, et al. High-resolution computed tomography characterization of interstitial lung diseases in polymyositis/dermatomyositis. J Rheumatol, 2008, 35(2): 260-269.
13. Tsuchiya Y, Fischer A, Solomon JJ, et al. Connective tissue disease-related thoracic disease. Clin Chest Med, 2015, 36(2): 283-297.

Chinese Journal of Respiratory and Critical Care Medicine

Clinical characteristics of amyopathic dermatomyositis with organizing pneumonia

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