Applicability test of the existing formula of normal predictive value of adult pulmonary diffusion capacity index in Kunming area_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

LI Yi ¹ , YANG Kunyu ² , LI Ling ¹ , HE Ying ¹ , LU Siping ¹ , ZHANG Hongling ¹ , DAI Jin’e ¹ ,  LI Shaoying ¹

1. 920th Hospital of Joint Logistics Support Force, Kunming, Yunnan, 650000, P. R. China;
2. The First People’s Hospital of Yunnan Province, Kunming, Yunnan, 650000, P. R. China;

Corresponding?author：

LI Shaoying, Email: 1024942115@qq.com

Keywords：

Adult; Lung function; Diffusing capacity of gas; Prediction; Adaptivity

DOI：

10.7507/1671-6205.201911023

Video：

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Objective To verify the existing domestic and foreign formulas of normal predictive value indicator for adult pulmonary diffusion capacity’s applicability at current stage in Kunming.Methods Based on the pulmonary diffusion capacity parameters determination of diffusion capacity for carbon monoxide of the lung (D_LCO) collected from one-breath breathing test completed by 680 adults with healthy lung function and without any disease which may cause pulmonary diffusion dysfunctions in Kunming, the regression equation of adult D_LCO normal predicted value in Kunming was initially established; the fitting degree of D_LCO predicted value and measured value was verified; and the correlation between European adults (instrument-inherent ECCS93) and the normal predicted values of adult D_LCO in Shanghai, Chongqing and Lhasa were calculated and contrasted.Results The regression equation of adult D_LCO normal predicted value in Kunming was initially established: for male, 0.483+0.063×height (cm)+0.041×weight (kg)–0.071×age (years); for female, 1.679+0.055×height (cm)+0.018×weight (kg)–0.060×age (years). The data collected from the one-breath breathing test were similar to the predicted values obtained from the normal adult male and female D_LCO prediction formulas in Kunming, the difference was not statistically significant (t_M=–0.167, t_F=–0.436, both P>0.05), suggesting that the formula for predicting the value established in this study was valid and well fitted. The predicted value of adult D_LCO in Kunming area was statistically significant compared with the adult D_LCO estimates of European adults and Lhasa, Chongqing and Shanghai in China (F_M=713.4, F_F=1 442.2, both P<0.001). Lhasa had the highest value; Kunming was the second highest; instrument-inherent European area and Chongqing came to third and fourth; and Shanghai had the lowest predicated adult D_LCO value (all P<0.001).Conclusion The current predictive formulas for adult pulmonary diffusion capacity indicators in China and worldwide are not suitable for the populations in Kunming.

Citation： LI Yi, YANG Kunyu, LI Ling, HE Ying, LU Siping, ZHANG Hongling, DAI Jin’e, LI Shaoying. Applicability test of the existing formula of normal predictive value of adult pulmonary diffusion capacity index in Kunming area. Chinese Journal of Respiratory and Critical Care Medicine, 2021, 20(3): 183-188. doi: 10.7507/1671-6205.201911023 Copy

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1. Jian WH, Gao Y, Hao CL, et al. Reference values for spirometry in Chinese aged 4-80 years. J Thorac Dis, 2017, 9(11): 4538-4549.
2. 郭娥, 關偉杰, 吳仲平, 等. 我國 2012 年與 2002 年肺功能應用調查對比分析. 中國實用內科雜志, 2014, 34(S1): 40-41.
3. 穆魁津, 劉世琬, 主編. 全國肺功能正常值匯編. 北京: 北京醫科大學、中國協和醫科大學聯合出版社, 1990.
4. 穆魁津, 劉世琬, 主編. 全國肺功能正常值匯編. 北京: 北京醫科大學、中國協和醫科大學聯合出版社, 1990, 38-56.
5. 孟祥英. 肺彌散功能測定的研究和臨床應用. 醫學信息(下旬刊), 2013, 26(7): 582-583.
6. 中華醫學會呼吸病學分會肺功能專業組. 肺功能檢查指南―肺彌散功能檢查. 中華結核和呼吸雜志, 2015, 38(3): 164-169.
7. Graham BL, Brusasco V, Burgos F, et al. 2017 ERS/ATS standards for single-breath carbon monoxide uptake in the lung. Eur Respir J, 2017, 49(1): 1600016.
8. 中華醫學會呼吸病學分會肺功能專業組. 肺功能檢查指南(第二部分)―肺量計檢查. 中華結核和呼吸雜志, 2014, 37(7): 481-486.
9. 中華醫學會呼吸病學分會肺功能專業組. 肺功能檢查指南—肺容量檢查. 中華結核和呼吸雜志, 2015, 38(4): 255-260.
10. 任為英, 朱蕾, 趙蓉雅, 等. 上海市成人肺功能醫學參考值范圍的初步研究. 中國呼吸與危重監護雜志, 2012, 11(3): 253-256.
11. 王金平, 賈巨才, 錢桂生. 肺彌散功能正常值及臨床應用探討. 第三軍醫大學學報, 1997, 19(1): 56-59.
12. 李英悅, 周亞玲, 主召新, 等. 拉薩地區健康移居成人肺功能的正常值及其預計公式. 中華結核和呼吸雜志, 1994, 17(2): 110-111.
13. 朱希, 李華德, 鈕善福, 等. 上海地區肺功能正常值和回歸方程//穆魁津, 劉世琬, 主編. 全國肺功能正常值匯編. 北京: 北京醫科大學、中國協和醫科大學聯合出版社, 1990, 57-66.
14. 侯恕, 張宇光, 郭小川, 等. 廣東地區肺功能正常值//穆魁津, 劉世琬, 主編. 全國肺功能正常值匯編. 北京: 北京醫科大學、中國協和醫科大學聯合出版社, 1990, 67-80.
15. 陳文彬, 殷大奎, 袁玉如, 等. 成都地區健康成人肺功能的正常值及其預計值公式//穆魁津, 劉世琬, 主編. 全國肺功能正常值匯編. 北京: 北京醫科大學、中國協和醫科大學聯合出版社, 1990, 48-56.
16. 楊昆豫, 劉斌, 鄧崢, 等. 不同海拔肺彌散功能分析. 中國誤診學雜志, 2004, 4(6): 868-869.

Chinese Journal of Respiratory and Critical Care Medicine

Applicability test of the existing formula of normal predictive value of adult pulmonary diffusion capacity index in Kunming area

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