白細胞介素-1 家族新成員 IL-36 和 IL-38 在哮喘作用機制中的研究進展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

廖增華 ,  李超乾

廣西醫科大學第一附屬醫院（廣西南寧 530021）;

Corresponding?author：

李超乾, Email: 2534776680@qq.com

Keywords：

DOI：

10.7507/1671-6205.202201005

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Citation： 廖增華, 李超乾. 白細胞介素-1 家族新成員 IL-36 和 IL-38 在哮喘作用機制中的研究進展. Chinese Journal of Respiratory and Critical Care Medicine, 2022, 21(6): 452-456. doi: 10.7507/1671-6205.202201005 Copy

1.	Teufel LU, Arts RJW, Netea MG, et al. IL-1 family cytokines as drivers and inhibitors of trained immunity. Cytokine, 2022, 150: 155773.
2.	Neurath MF. IL-36 in chronic inflammation and cancer. Cytokine Growth Factor Rev, 2020, 55: 70-79.
3.	Pe?aloza HF, van der Geest R, Ybe JA, et al. Interleukin-36 cytokines in infectious and non-infectious lung diseases. Front Immunol, 2021, 12: 754702.
4.	何明欣, 張華, 周向東, 等. 白細胞介素-1 受體相關激酶通過 TLR-4/MyD88 信號通路調控內毒素誘導的氣道黏液高分泌. 中國呼吸與危重監護雜志, 2022, 21(1): 50-54.
5.	Elias M, Zhao S, Le HT, et al. IL-36 in chronic inflammation and fibrosis - bridging the gap?. J Clin Invest, 2021, 131(2): e144336.
6.	Tsang MS, Sun XY, Wong CK. The role of new IL-1 family members (IL-36 and IL-38) in atopic dermatitis, allergic asthma, and allergic rhinitis. Curr Allergy Asthma Rep, 2020, 20(8): 40.
7.	Lin HS, Ho AS, Haley-Vicente D, et al. Cloning and characterization of IL-1HY2, a novel interleukin-1 family member. J Biol Chem, 2001, 276(23): 20597-20602.
8.	Bensen JT, Dawson PA, Mychaleckyj JC, et al. Identification of a novel human cytokine gene in the interleukin gene cluster on chromosome 2q12-14. J Interf Cytok Res, 2001, 21(11): 899-904.
9.	van de Veerdonk FL, Stoeckman AK, Wu G, et al. IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist. Proc Natl Acad Sci U S A, 2012, 109(8): 3001-3005.
10.	Xie LH, Huang ZH, Li H, et al. IL-38: a new player in inflammatory autoimmune disorders. Biomolecules, 2019, 9(8): 345.
11.	Ramadas RA, Li XN, Shubitowski DM, et al. IL-1 receptor antagonist as a positional candidate gene in a murine model of allergic asthma. Immunogenetics, 2006, 58(10): 851-855.
12.	Liu XG, Li J, Zheng LJ, et al. Interleukin-36 receptor antagonist alleviates airway inflammation in asthma via inhibiting the activation of interleukin-36 pathway. Int Immunopharmacol, 2020, 81: 106200.
13.	Qin X, Liu M, Zhang S, et al. The role of IL-36gamma and its regulation in eosinophilic inflammation in allergic rhinitis. Cytokine, 2019, 117: 84-90.
14.	Koss CK, Wohnhaas CT, Baker JR, et al. IL36 is a critical upstream amplifier of neutrophilic lung inflammation in mice. Commun Biol, 2021, 4(1): 172.
15.	肖夏夏, 魯珊珊, 申秋燕, 等. 支氣管哮喘患兒血清 IL-17 和 IL-36 水平及臨床意義. 中國兒童保健雜志, 2019, 27(6): 646-648.
16.	趙艷景, 鮑文華, 李樹民, 等. 支氣管哮喘患者呼出氣一氧化氮、血清 IL-36 水平及其相關性. 臨床肺科雜志, 2018, 23(2): 312-314.
17.	孟亞奇, 賈嫚, 姜潔, 等. IL-36γ 在哮喘患者血清及支氣管上皮細胞中的表達及意義. 南京醫科大學學報(自然科學版), 2018, 38(9): 1264-1268,1274.
18.	孫姝玲, 嚴靜琪, 郭利濤, 等. 重癥哮喘患者血清白介素-36γ、骨膜蛋白水平與無創正壓通氣效果的相關性. 疑難病雜志, 2021, 20(7): 685-689.
19.	Mora J, Schlemmer A, Wittig I, et al. Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses. J Mol Cell Biol, 2016, 8(5): 426-438.
20.	Zhang S, Gang X, Yang S, et al. The alterations in and the role of the Th17/Treg balance in metabolic diseases. Front Immunol, 2021, 12: 678355.
21.	Yao YE, Qin CC, Yang CM, et al. γδT17/γδTreg cell subsets: a new paradigm for asthma treatment. J Asthma, 2021: 1-11.
22.	Sun XY, Hou TH, Cheung E, et al. Anti-inflammatory mechanisms of the novel cytokine interleukin-38 in allergic asthma. Cell Mol Immunol, 2020, 17(6): 631-646.
23.	Chu M, Chu IMT, Yung ECM, et al. Aberrant expression of novel cytokine IL-38 and regulatory T lymphocytes in childhood asthma. Molecules, 2016, 21(7): 933.
24.	李鑫, 鮑文華, 孫云暉, 等. 支氣管哮喘患者誘導痰上清白細胞介素-17 及 38 的表達水平及其臨床意義. 廣西醫學, 2017, 39(10): 1512-1514.
25.	Gao X, Chan PKS, Lui GCY, et al. Interleukin-38 ameliorates poly(I: C) induced lung inflammation: therapeutic implications in respiratory viral infections. Cell Death Dis, 2021, 12(1): 53.
26.	Matsuoka M, Kawayama T, Tominaga M, et al. Attenuated airway eosinophilic inflammations in IL-38 knockout mouse model. Kurume Med J, 2019, 65(2): 37-46.
27.	杜威, 杜娟, 周俊, 等. 白細胞介素-25 及其受體對過敏性哮喘患者嗜酸性粒細胞的調控作用. 中國呼吸與危重監護雜志, 2019, 18(3): 247-253.

1. Teufel LU, Arts RJW, Netea MG, et al. IL-1 family cytokines as drivers and inhibitors of trained immunity. Cytokine, 2022, 150: 155773.
2. Neurath MF. IL-36 in chronic inflammation and cancer. Cytokine Growth Factor Rev, 2020, 55: 70-79.
3. Pe?aloza HF, van der Geest R, Ybe JA, et al. Interleukin-36 cytokines in infectious and non-infectious lung diseases. Front Immunol, 2021, 12: 754702.
4. 何明欣, 張華, 周向東, 等. 白細胞介素-1 受體相關激酶通過 TLR-4/MyD88 信號通路調控內毒素誘導的氣道黏液高分泌. 中國呼吸與危重監護雜志, 2022, 21(1): 50-54.
5. Elias M, Zhao S, Le HT, et al. IL-36 in chronic inflammation and fibrosis - bridging the gap?. J Clin Invest, 2021, 131(2): e144336.
6. Tsang MS, Sun XY, Wong CK. The role of new IL-1 family members (IL-36 and IL-38) in atopic dermatitis, allergic asthma, and allergic rhinitis. Curr Allergy Asthma Rep, 2020, 20(8): 40.
7. Lin HS, Ho AS, Haley-Vicente D, et al. Cloning and characterization of IL-1HY2, a novel interleukin-1 family member. J Biol Chem, 2001, 276(23): 20597-20602.
8. Bensen JT, Dawson PA, Mychaleckyj JC, et al. Identification of a novel human cytokine gene in the interleukin gene cluster on chromosome 2q12-14. J Interf Cytok Res, 2001, 21(11): 899-904.
9. van de Veerdonk FL, Stoeckman AK, Wu G, et al. IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist. Proc Natl Acad Sci U S A, 2012, 109(8): 3001-3005.
10. Xie LH, Huang ZH, Li H, et al. IL-38: a new player in inflammatory autoimmune disorders. Biomolecules, 2019, 9(8): 345.
11. Ramadas RA, Li XN, Shubitowski DM, et al. IL-1 receptor antagonist as a positional candidate gene in a murine model of allergic asthma. Immunogenetics, 2006, 58(10): 851-855.
12. Liu XG, Li J, Zheng LJ, et al. Interleukin-36 receptor antagonist alleviates airway inflammation in asthma via inhibiting the activation of interleukin-36 pathway. Int Immunopharmacol, 2020, 81: 106200.
13. Qin X, Liu M, Zhang S, et al. The role of IL-36gamma and its regulation in eosinophilic inflammation in allergic rhinitis. Cytokine, 2019, 117: 84-90.
14. Koss CK, Wohnhaas CT, Baker JR, et al. IL36 is a critical upstream amplifier of neutrophilic lung inflammation in mice. Commun Biol, 2021, 4(1): 172.
15. 肖夏夏, 魯珊珊, 申秋燕, 等. 支氣管哮喘患兒血清 IL-17 和 IL-36 水平及臨床意義. 中國兒童保健雜志, 2019, 27(6): 646-648.
16. 趙艷景, 鮑文華, 李樹民, 等. 支氣管哮喘患者呼出氣一氧化氮、血清 IL-36 水平及其相關性. 臨床肺科雜志, 2018, 23(2): 312-314.
17. 孟亞奇, 賈嫚, 姜潔, 等. IL-36γ 在哮喘患者血清及支氣管上皮細胞中的表達及意義. 南京醫科大學學報(自然科學版), 2018, 38(9): 1264-1268,1274.
18. 孫姝玲, 嚴靜琪, 郭利濤, 等. 重癥哮喘患者血清白介素-36γ、骨膜蛋白水平與無創正壓通氣效果的相關性. 疑難病雜志, 2021, 20(7): 685-689.
19. Mora J, Schlemmer A, Wittig I, et al. Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses. J Mol Cell Biol, 2016, 8(5): 426-438.
20. Zhang S, Gang X, Yang S, et al. The alterations in and the role of the Th17/Treg balance in metabolic diseases. Front Immunol, 2021, 12: 678355.
21. Yao YE, Qin CC, Yang CM, et al. γδT17/γδTreg cell subsets: a new paradigm for asthma treatment. J Asthma, 2021: 1-11.
22. Sun XY, Hou TH, Cheung E, et al. Anti-inflammatory mechanisms of the novel cytokine interleukin-38 in allergic asthma. Cell Mol Immunol, 2020, 17(6): 631-646.
23. Chu M, Chu IMT, Yung ECM, et al. Aberrant expression of novel cytokine IL-38 and regulatory T lymphocytes in childhood asthma. Molecules, 2016, 21(7): 933.
24. 李鑫, 鮑文華, 孫云暉, 等. 支氣管哮喘患者誘導痰上清白細胞介素-17 及 38 的表達水平及其臨床意義. 廣西醫學, 2017, 39(10): 1512-1514.
25. Gao X, Chan PKS, Lui GCY, et al. Interleukin-38 ameliorates poly(I: C) induced lung inflammation: therapeutic implications in respiratory viral infections. Cell Death Dis, 2021, 12(1): 53.
26. Matsuoka M, Kawayama T, Tominaga M, et al. Attenuated airway eosinophilic inflammations in IL-38 knockout mouse model. Kurume Med J, 2019, 65(2): 37-46.
27. 杜威, 杜娟, 周俊, 等. 白細胞介素-25 及其受體對過敏性哮喘患者嗜酸性粒細胞的調控作用. 中國呼吸與危重監護雜志, 2019, 18(3): 247-253.

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白細胞介素-1 家族新成員 IL-36 和 IL-38 在哮喘作用機制中的研究進展

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