慢性阻塞性肺疾病過度充氣的研究進展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

段昊玙 ¹ , LI Yuqi ¹ ,  LIANG Binmiao ²

1. ;
2. ;

Corresponding?author：

LIANG Binmiao, Email: liangbinmiao@163.com

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DOI：

10.7507/1671-6205.202207065

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Citation： LI Yuqi, LIANG Binmiao. 慢性阻塞性肺疾病過度充氣的研究進展. Chinese Journal of Respiratory and Critical Care Medicine, 2022, 21(12): 904-908. doi: 10.7507/1671-6205.202207065 Copy

1.	Vogelmeier CF, Criner GJ, Martinez FJ, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 report. Gold executive summary. Am J Respir Crit Care Med, 2017, 195(5): 557-582.
2.	Gagnon P, Guenette JA, Langer D, et al. Pathogenesis of hyperinflation in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis, 2014, 9(1): 187-201.
3.	O'Donnell DE, Elbehairy AF, Webb KA, et al. The link between reduced inspiratory capacity and exercise intolerance in chronic obstructive pulmonary disease. Ann Am Thorac Soc, 2017, 14(Supplement_1): S30-S39.
4.	Rossi A, Aisanov Z, Avdeev S, et al. Mechanisms, assessment and therapeutic implications of lung hyperinflation in COPD. Respir Med, 2015, 109(7): 785-802.
5.	O'Donnell DE, Laveneziana P. Physiology and consequences of lung hyperinflation in COPD. Eur Respir Rev, 2006, 15(100): 61-67.
6.	Alter P, Orszag J, Kellerer C, et al. Prediction of air trapping or pulmonary hyperinflation by forced spirometry in COPD patients: results from COSYCONET. ERJ Open Res, 2020, 6(3): 00092-2020.
7.	Park J, Lee CH, Lee YJ, et al. Longitudinal changes in lung hyperinflation in COPD. Int J Chron Obstruct Pulmon Dis, 2017, 12: 501-508.
8.	Alter P, Rabe KF, Schulz H, et al. Influence of body mass on predicted values of static hyperinflation in COPD. Int J Chron Obstruct Pulmon Dis, 2018, 13: 2551-2555.
9.	Lee J, Lee CT, Lee JH, et al. Graphic analysis of flow-volume curves: a pilot study. BMC Pulm Med, 2016, 16(1): 18. Erratum in: BMC Pulm Med, 2016, 16(1): 115.
10.	Caviezel C. Lung volume reduction surgery in selected patients with severe emphysema: significant benefit with low peri-operative risk. J Xiangya Med, 2017, 2(6): 48.
11.	O’Donnell DE, Webb KA, Neder JA. Lung hyperinflation in COPD: applying physiology to clinical practice. COPD Res Pract, 2015, 1(1): 4.
12.	Das N, Topalovic M, Aerts JM, et al. Area under the forced expiratory flow-volume loop in spirometry indicates severe hyperinflation in COPD patients. Int J Chron Obstruct Pulmon Dis, 2019, 14: 409-418.
13.	Ladeira I, Oliveira P, Gomes J, et al. Can static hyperinflation predict exercise capacity in COPD?[J/OL]. Pulmonology, 2021, S2531-0437(21): 00188-4.
14.	Luo YM, Qiu ZH, Wang Y, et al. Absence of dynamic hyperinflation during exhaustive exercise in severe COPD reflects submaximal IC maneuvers rather than a nonhyperinflator phenotype. J Appl Physiol (1985), 2020, 128(3): 586-595.
15.	Varga J, Casaburi R, Ma SY, et al. Relation of concavity in the expiratory flow-volume loop to dynamic hyperinflation during exercise in COPD. Respir Physiol Neurobiol, 2016, 234: 79-84.
16.	Chuang ML, Hsieh MJ, Wu TC, et al. Developing a new marker of dynamic hyperinflation in patients with obstructive airway disease - an observational study. Sci Rep, 2019, 9(1): 7514.
17.	Mannée D, Vis E, Hoekstra-Kuik A, et al. Is the metronome-paced tachypnea test (MPT) ready for clinical use? Accuracy of the MPT in a prospective and clinical study. Respiration, 2019, 97(6): 569-575.
18.	Kawachi S, Fujimoto K. Metronome-paced incremental hyperventilation may predict exercise tolerance and dyspnea as a surrogate for dynamic lung hyperinflation during exercise. Int J Chron Obstruct Pulmon Dis, 2020, 15: 1061-1069.
19.	Fujimoto K, Yamazaki H, Ura M, et al. Efficacy of tiotropium and indacaterol monotherapy and their combination on dynamic lung hyperinflation in COPD: a random open-label crossover study. Int J Chron Obstruct Pulmon Dis, 2017, 12: 3195-3201.
20.	Kawachi S, Fujimoto K. Efficacy of tiotropium and olodaterol combination therapy on dynamic lung hyperinflation evaluated by hyperventilation in COPD: An open-label, comparative before and after treatment study. Int J Chron Obstruct Pulmon Dis, 2019, 14: 1167-1176.
21.	Desiraju K, Agrawal A. Impulse oscillometry: the state-of-art for lung function testing. Lung India, 2016, 33(4): 410-416.
22.	Milne S, Hammans C, Watson S, et al. Bronchodilator responses in respiratory impedance, hyperinflation and gas trapping in COPD. COPD, 2018, 15(4): 341-349.
23.	D'Ascanio M, Viccaro F, Calabrò N, et al. Assessing static lung hyperinflation by whole-body plethysmography, helium dilution, and impulse oscillometry system (ios) in patients with COPD. Int J Chron Obstruct Pulmon Dis, 2020, 15: 2583-2589.
24.	Singh D. Small airway disease in patients with chronic obstructive pulmonary disease. Tuberc Respir Dis (Seoul), 2017, 80(4): 317-324.
25.	Kitaguchi Y, Fujimoto K, Kubo K, et al. Characteristics of COPD phenotypes classified according to the findings of HRCT. Respir Med, 2006, 100(10): 1742-1752.
26.	van Geffen WH, Kerstjens HA. Static and dynamic hyperinflation during severe acute exacerbations of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis, 2018, 13: 1269-1277.
27.	Parker CM, Voduc N, Aaron SD, et al. Physiological changes during symptom recovery from moderate exacerbations of COPD. Eur Respir J, 2005, 26(3): 420-428.
28.	Kir E, Güven Atici A, Güllü YT, et al. The relationship between serum uric acid level and uric acid/creatinine ratio with chronic obstructive pulmonary disease severity (stable or acute exacerbation) and the development of cor pulmonale. Int J Clin Pract, 2021, 75(8): e14303.
29.	Kumar K, Gupta PP, Verma AK, et al. Assessment of prevalence and characteristics of asthma-COPD overlap among patients with chronic airflow obstruction[J/OL]. Monaldi Arch Chest Dis, 2022.
30.	Pon?ot-Mongars R, Zysman M, Regent D, et al. Combined pulmonary fibrosis and emphysema: the natural history of the disease. The chronological evolution of clinical features, respiratory function and the CT scan. Rev Mal Respir, 2013, 30(3): 222-226.
31.	Schmidt M, Cattani-Cavalieri I, Nu?ez FJ, et al. Phosphodiesterase isoforms and cAMP compartments in the development of new therapies for obstructive pulmonary diseases. Curr Opin Pharmacol, 2020, 51: 34-42.
32.	Arbex MA, de Souza Concei??o GM, Cendon SP, et al. Urban air pollution and chronic obstructive pulmonary disease-related emergency department visits. J Epidemiol Community Health, 2009, 63(10): 777-783.
33.	Peel JL, Tolbert PE, Klein M, et al. Ambient air pollution and respiratory emergency department visits. Epidemiology, 2005, 16(2): 164-174.
34.	Wongsurakiat P, Maranetra KN, Wasi C, et al. Acute respiratory illness in patients with COPD and the effectiveness of influenza vaccination: a randomized controlled study. Chest, 2004, 125(6): 2011-2020.
35.	Gorse GJ, O'Connor TZ, Young SL, et al. Impact of a winter respiratory virus season on patients with COPD and association with influenza vaccination. Chest, 2006, 130(4): 1109-1116.
36.	謝媛媛, 歐陽玥, 翟福利, 等. 慢性阻塞性肺疾病急性加重期氣道病原體季節變化的前瞻性觀察隊列研究. 臨床肺科雜志, 2019, 24(1): 5.
37.	Donaldson G, Wedzicha J. The causes and consequences of seasonal variation in COPD exacerbations. Int J Chron Obstruct Pulmon Dis, 2014, 9(1): 1101-1110.
38.	Casanova C, Marin JM, Martinez-Gonzalez C, et al. Differential effect of modified medical research council dyspnea, COPD assessment test, and clinical COPD questionnaire for symptoms evaluation within the new gold staging and mortality in COPD. Chest, 2015, 148(1): 159-168.
39.	Agarwala P, Salzman SH. Six-minute walk test. Clinical role, technique, coding, and reimbursement. Chest, 2020, 157(3): 603-611.
40.	Felipe C, Bartolome C, Miguel D, et al. Longitudinal changes in handgrip strength, hyperinflation, and 6-minute walk distance in patients with COPD and a control group. Chest, 2015, 148(4): 986-994.
41.	Ramon MA, Ferrer J, Gimeno-Santos E, et al. Inspiratory capacity-to-total lung capacity ratio and dyspnoea predict exercise capacity decline in COPD. Respirology, 2016, 21(3): 476-482.
42.	Aalstad LT, Hardie JA, Espehaug B, et al. Lung hyperinflation and functional exercise capacity in patients with COPD - a three-year longitudinal study. BMC Pulm Med, 2018, 18(1): 187.
43.	Annegarn J, Meijer K, Passos VL, et al. Problematic activities of daily life are weakly associated with clinical characteristics in COPD. J Am Med Dir Assoc, 2012, 13(3): 284-290.
44.	Bendixen HJ, W?hrens EE, Wilcke JT, et al. Self-reported quality of ADL task performance among patients with COPD exacerbations. Scand J Occup Ther, 2014, 21(4): 313-320.
45.	Janssen DJ, Wouters EF, Spruit MA. Psychosocial consequences of living with breathlessness due to advanced disease. Curr Opin Support Palliat Care, 2015, 9(3): 232-237.
46.	Lahaije AJ, van Helvoort HA, Dekhuijzen PN, et al. Resting and ADL-induced dynamic hyperinflation explain physical inactivity in COPD better than FEV₁. Respir Med, 2013, 107(6): 834-840.
47.	van Helvoort HA, Willems LM, Dekhuijzen PR, et al. Respiratory constraints during activities in daily life and the impact on health status in patients with early-stage COPD: a cross-sectional study. NPJ Prim Care Respir Med, 2016, 26: 16054.
48.	Laveneziana P, Albuquerque A, Aliverti A, et al. ERS statement on respiratory muscle testing at rest and during exercise. Eur Respir J, 2019, 53(6): 1801214.
49.	Shiraishi M, Higashimoto Y, Sugiya R, et al. Diaphragmatic excursion correlates with exercise capacity and dynamic hyperinflation in COPD patients. ERJ Open Res, 2020, 6(4): 00589-2020.
50.	Kim NS, Seo JH, Ko MH, et al. Respiratory muscle strength in patients with chronic obstructive pulmonary disease. Ann Rehabil Med, 2017, 41(4): 659-666.
51.	Scheibe N, Sosnowski N, Pinkhasik A, et al. Sonographic evaluation of diaphragmatic dysfunction in COPD patients. Int J Chron Obstruct Pulmon Dis, 2015, 10(1): 1925-1930.
52.	Rocha FR, Brüggemann AK, Francisco DS, et al. Diaphragmatic mobility: relationship with lung function, respiratory muscle strength, dyspnea, and physical activity in daily life in patients with COPD. J Bras Pneumol, 2017, 43(1): 32-37.
53.	Marino S, Bettini P, Pini L, et al. Effects of chronic and acute pulmonary hyperinflation on phrenic nerve conduction in patients with COPD. COPD, 2020, 17(4): 378-383.
54.	Marchioni A, Tonelli R, Fantini R, et al. Respiratory mechanics and diaphragmatic dysfunction in COPD patients who failed non-invasive mechanical ventilation. Int J Chron Obstruct Pulmon Dis, 2019, 14: 2575-2585.
55.	O'Donnell DE, Elbehairy AF, Berton DC, et al. Advances in the evaluation of respiratory pathophysiology during exercise in chronic lung diseases. Front Physiol, 2017, 8: 82.
56.	Langer D, Ciavaglia CE, Neder JA, et al. Lung hyperinflation in chronic obstructive pulmonary disease: Mechanisms, clinical implications and treatment. Expert Rev Respir Med, 2014, 8(6): 731-749.
57.	Gass R, Merola P, Monteiro MB, et al. Effects of expiratory positive airway pressure on exercise tolerance, dynamic hyperinflation, and dyspnea in COPD. Respir Care, 2017, 62(10): 1298-1306.
58.	Cardoso DM, Gass R, Sbruzzi G, et al. Effect of the expiratory positive airway pressure on dynamic hyperinflation and exercise capacity in patients with COPD: a meta-analysis. Sci Rep, 2020, 10(1): 13292.
59.	Müller PT, Christofoletti G, Koch R, et al. CPAP and EPAP elicit similar lung deflation in a non‐equivalent mode in GOLD 3‐4 COPD patients. Clin Respir J, 2018, 12(4): 1598-1606.
60.	Dennis CJ, Menadue C, Schneeberger T, et al. Bilevel non-invasive ventilation during exercise reduces dynamic hyperinflation and improves cycle endurance time in severe to very severe COPD. Chest, 2021, 160(6): 2066-2079.

1. Vogelmeier CF, Criner GJ, Martinez FJ, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 report. Gold executive summary. Am J Respir Crit Care Med, 2017, 195(5): 557-582.
2. Gagnon P, Guenette JA, Langer D, et al. Pathogenesis of hyperinflation in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis, 2014, 9(1): 187-201.
3. O'Donnell DE, Elbehairy AF, Webb KA, et al. The link between reduced inspiratory capacity and exercise intolerance in chronic obstructive pulmonary disease. Ann Am Thorac Soc, 2017, 14(Supplement_1): S30-S39.
4. Rossi A, Aisanov Z, Avdeev S, et al. Mechanisms, assessment and therapeutic implications of lung hyperinflation in COPD. Respir Med, 2015, 109(7): 785-802.
5. O'Donnell DE, Laveneziana P. Physiology and consequences of lung hyperinflation in COPD. Eur Respir Rev, 2006, 15(100): 61-67.
6. Alter P, Orszag J, Kellerer C, et al. Prediction of air trapping or pulmonary hyperinflation by forced spirometry in COPD patients: results from COSYCONET. ERJ Open Res, 2020, 6(3): 00092-2020.
7. Park J, Lee CH, Lee YJ, et al. Longitudinal changes in lung hyperinflation in COPD. Int J Chron Obstruct Pulmon Dis, 2017, 12: 501-508.
8. Alter P, Rabe KF, Schulz H, et al. Influence of body mass on predicted values of static hyperinflation in COPD. Int J Chron Obstruct Pulmon Dis, 2018, 13: 2551-2555.
9. Lee J, Lee CT, Lee JH, et al. Graphic analysis of flow-volume curves: a pilot study. BMC Pulm Med, 2016, 16(1): 18. Erratum in: BMC Pulm Med, 2016, 16(1): 115.
10. Caviezel C. Lung volume reduction surgery in selected patients with severe emphysema: significant benefit with low peri-operative risk. J Xiangya Med, 2017, 2(6): 48.
11. O’Donnell DE, Webb KA, Neder JA. Lung hyperinflation in COPD: applying physiology to clinical practice. COPD Res Pract, 2015, 1(1): 4.
12. Das N, Topalovic M, Aerts JM, et al. Area under the forced expiratory flow-volume loop in spirometry indicates severe hyperinflation in COPD patients. Int J Chron Obstruct Pulmon Dis, 2019, 14: 409-418.
13. Ladeira I, Oliveira P, Gomes J, et al. Can static hyperinflation predict exercise capacity in COPD?[J/OL]. Pulmonology, 2021, S2531-0437(21): 00188-4.
14. Luo YM, Qiu ZH, Wang Y, et al. Absence of dynamic hyperinflation during exhaustive exercise in severe COPD reflects submaximal IC maneuvers rather than a nonhyperinflator phenotype. J Appl Physiol (1985), 2020, 128(3): 586-595.
15. Varga J, Casaburi R, Ma SY, et al. Relation of concavity in the expiratory flow-volume loop to dynamic hyperinflation during exercise in COPD. Respir Physiol Neurobiol, 2016, 234: 79-84.
16. Chuang ML, Hsieh MJ, Wu TC, et al. Developing a new marker of dynamic hyperinflation in patients with obstructive airway disease - an observational study. Sci Rep, 2019, 9(1): 7514.
17. Mannée D, Vis E, Hoekstra-Kuik A, et al. Is the metronome-paced tachypnea test (MPT) ready for clinical use? Accuracy of the MPT in a prospective and clinical study. Respiration, 2019, 97(6): 569-575.
18. Kawachi S, Fujimoto K. Metronome-paced incremental hyperventilation may predict exercise tolerance and dyspnea as a surrogate for dynamic lung hyperinflation during exercise. Int J Chron Obstruct Pulmon Dis, 2020, 15: 1061-1069.
19. Fujimoto K, Yamazaki H, Ura M, et al. Efficacy of tiotropium and indacaterol monotherapy and their combination on dynamic lung hyperinflation in COPD: a random open-label crossover study. Int J Chron Obstruct Pulmon Dis, 2017, 12: 3195-3201.
20. Kawachi S, Fujimoto K. Efficacy of tiotropium and olodaterol combination therapy on dynamic lung hyperinflation evaluated by hyperventilation in COPD: An open-label, comparative before and after treatment study. Int J Chron Obstruct Pulmon Dis, 2019, 14: 1167-1176.
21. Desiraju K, Agrawal A. Impulse oscillometry: the state-of-art for lung function testing. Lung India, 2016, 33(4): 410-416.
22. Milne S, Hammans C, Watson S, et al. Bronchodilator responses in respiratory impedance, hyperinflation and gas trapping in COPD. COPD, 2018, 15(4): 341-349.
23. D'Ascanio M, Viccaro F, Calabrò N, et al. Assessing static lung hyperinflation by whole-body plethysmography, helium dilution, and impulse oscillometry system (ios) in patients with COPD. Int J Chron Obstruct Pulmon Dis, 2020, 15: 2583-2589.
24. Singh D. Small airway disease in patients with chronic obstructive pulmonary disease. Tuberc Respir Dis (Seoul), 2017, 80(4): 317-324.
25. Kitaguchi Y, Fujimoto K, Kubo K, et al. Characteristics of COPD phenotypes classified according to the findings of HRCT. Respir Med, 2006, 100(10): 1742-1752.
26. van Geffen WH, Kerstjens HA. Static and dynamic hyperinflation during severe acute exacerbations of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis, 2018, 13: 1269-1277.
27. Parker CM, Voduc N, Aaron SD, et al. Physiological changes during symptom recovery from moderate exacerbations of COPD. Eur Respir J, 2005, 26(3): 420-428.
28. Kir E, Güven Atici A, Güllü YT, et al. The relationship between serum uric acid level and uric acid/creatinine ratio with chronic obstructive pulmonary disease severity (stable or acute exacerbation) and the development of cor pulmonale. Int J Clin Pract, 2021, 75(8): e14303.
29. Kumar K, Gupta PP, Verma AK, et al. Assessment of prevalence and characteristics of asthma-COPD overlap among patients with chronic airflow obstruction[J/OL]. Monaldi Arch Chest Dis, 2022.
30. Pon?ot-Mongars R, Zysman M, Regent D, et al. Combined pulmonary fibrosis and emphysema: the natural history of the disease. The chronological evolution of clinical features, respiratory function and the CT scan. Rev Mal Respir, 2013, 30(3): 222-226.
31. Schmidt M, Cattani-Cavalieri I, Nu?ez FJ, et al. Phosphodiesterase isoforms and cAMP compartments in the development of new therapies for obstructive pulmonary diseases. Curr Opin Pharmacol, 2020, 51: 34-42.
32. Arbex MA, de Souza Concei??o GM, Cendon SP, et al. Urban air pollution and chronic obstructive pulmonary disease-related emergency department visits. J Epidemiol Community Health, 2009, 63(10): 777-783.
33. Peel JL, Tolbert PE, Klein M, et al. Ambient air pollution and respiratory emergency department visits. Epidemiology, 2005, 16(2): 164-174.
34. Wongsurakiat P, Maranetra KN, Wasi C, et al. Acute respiratory illness in patients with COPD and the effectiveness of influenza vaccination: a randomized controlled study. Chest, 2004, 125(6): 2011-2020.
35. Gorse GJ, O'Connor TZ, Young SL, et al. Impact of a winter respiratory virus season on patients with COPD and association with influenza vaccination. Chest, 2006, 130(4): 1109-1116.
36. 謝媛媛, 歐陽玥, 翟福利, 等. 慢性阻塞性肺疾病急性加重期氣道病原體季節變化的前瞻性觀察隊列研究. 臨床肺科雜志, 2019, 24(1): 5.
37. Donaldson G, Wedzicha J. The causes and consequences of seasonal variation in COPD exacerbations. Int J Chron Obstruct Pulmon Dis, 2014, 9(1): 1101-1110.
38. Casanova C, Marin JM, Martinez-Gonzalez C, et al. Differential effect of modified medical research council dyspnea, COPD assessment test, and clinical COPD questionnaire for symptoms evaluation within the new gold staging and mortality in COPD. Chest, 2015, 148(1): 159-168.
39. Agarwala P, Salzman SH. Six-minute walk test. Clinical role, technique, coding, and reimbursement. Chest, 2020, 157(3): 603-611.
40. Felipe C, Bartolome C, Miguel D, et al. Longitudinal changes in handgrip strength, hyperinflation, and 6-minute walk distance in patients with COPD and a control group. Chest, 2015, 148(4): 986-994.
41. Ramon MA, Ferrer J, Gimeno-Santos E, et al. Inspiratory capacity-to-total lung capacity ratio and dyspnoea predict exercise capacity decline in COPD. Respirology, 2016, 21(3): 476-482.
42. Aalstad LT, Hardie JA, Espehaug B, et al. Lung hyperinflation and functional exercise capacity in patients with COPD - a three-year longitudinal study. BMC Pulm Med, 2018, 18(1): 187.
43. Annegarn J, Meijer K, Passos VL, et al. Problematic activities of daily life are weakly associated with clinical characteristics in COPD. J Am Med Dir Assoc, 2012, 13(3): 284-290.
44. Bendixen HJ, W?hrens EE, Wilcke JT, et al. Self-reported quality of ADL task performance among patients with COPD exacerbations. Scand J Occup Ther, 2014, 21(4): 313-320.
45. Janssen DJ, Wouters EF, Spruit MA. Psychosocial consequences of living with breathlessness due to advanced disease. Curr Opin Support Palliat Care, 2015, 9(3): 232-237.
46. Lahaije AJ, van Helvoort HA, Dekhuijzen PN, et al. Resting and ADL-induced dynamic hyperinflation explain physical inactivity in COPD better than FEV₁. Respir Med, 2013, 107(6): 834-840.
47. van Helvoort HA, Willems LM, Dekhuijzen PR, et al. Respiratory constraints during activities in daily life and the impact on health status in patients with early-stage COPD: a cross-sectional study. NPJ Prim Care Respir Med, 2016, 26: 16054.
48. Laveneziana P, Albuquerque A, Aliverti A, et al. ERS statement on respiratory muscle testing at rest and during exercise. Eur Respir J, 2019, 53(6): 1801214.
49. Shiraishi M, Higashimoto Y, Sugiya R, et al. Diaphragmatic excursion correlates with exercise capacity and dynamic hyperinflation in COPD patients. ERJ Open Res, 2020, 6(4): 00589-2020.
50. Kim NS, Seo JH, Ko MH, et al. Respiratory muscle strength in patients with chronic obstructive pulmonary disease. Ann Rehabil Med, 2017, 41(4): 659-666.
51. Scheibe N, Sosnowski N, Pinkhasik A, et al. Sonographic evaluation of diaphragmatic dysfunction in COPD patients. Int J Chron Obstruct Pulmon Dis, 2015, 10(1): 1925-1930.
52. Rocha FR, Brüggemann AK, Francisco DS, et al. Diaphragmatic mobility: relationship with lung function, respiratory muscle strength, dyspnea, and physical activity in daily life in patients with COPD. J Bras Pneumol, 2017, 43(1): 32-37.
53. Marino S, Bettini P, Pini L, et al. Effects of chronic and acute pulmonary hyperinflation on phrenic nerve conduction in patients with COPD. COPD, 2020, 17(4): 378-383.
54. Marchioni A, Tonelli R, Fantini R, et al. Respiratory mechanics and diaphragmatic dysfunction in COPD patients who failed non-invasive mechanical ventilation. Int J Chron Obstruct Pulmon Dis, 2019, 14: 2575-2585.
55. O'Donnell DE, Elbehairy AF, Berton DC, et al. Advances in the evaluation of respiratory pathophysiology during exercise in chronic lung diseases. Front Physiol, 2017, 8: 82.
56. Langer D, Ciavaglia CE, Neder JA, et al. Lung hyperinflation in chronic obstructive pulmonary disease: Mechanisms, clinical implications and treatment. Expert Rev Respir Med, 2014, 8(6): 731-749.
57. Gass R, Merola P, Monteiro MB, et al. Effects of expiratory positive airway pressure on exercise tolerance, dynamic hyperinflation, and dyspnea in COPD. Respir Care, 2017, 62(10): 1298-1306.
58. Cardoso DM, Gass R, Sbruzzi G, et al. Effect of the expiratory positive airway pressure on dynamic hyperinflation and exercise capacity in patients with COPD: a meta-analysis. Sci Rep, 2020, 10(1): 13292.
59. Müller PT, Christofoletti G, Koch R, et al. CPAP and EPAP elicit similar lung deflation in a non‐equivalent mode in GOLD 3‐4 COPD patients. Clin Respir J, 2018, 12(4): 1598-1606.
60. Dennis CJ, Menadue C, Schneeberger T, et al. Bilevel non-invasive ventilation during exercise reduces dynamic hyperinflation and improves cycle endurance time in severe to very severe COPD. Chest, 2021, 160(6): 2066-2079.

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慢性阻塞性肺疾病過度充氣的研究進展

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