Chronic cough and risk of cerebrovascular disease: a prospective cohort study_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

ZHU Zhenbin ¹ , YANG Xiaoxia ² , CHEN Min ³ , LIU Tao ³ , TIAN Kunming ² ,  DENG Renli ⁴

1. Department of Emergency, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P. R. China;
2. Department of Preventive Medicine, School of Public Health, Zunyi Medical University, Zunyi, Guizhou 563006, P. R. China;
3. Department of Chronic Disease Prevention and Control, Guiyang, Guizhou 550004, P. R. China;
4. Department of Nursing, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 519000, P. R. China;

Corresponding?author：

DENG Renli, Email: renli_deng@163.com

Keywords：

Chronic cough; cerebrovascular disease; risk; cohort study

DOI：

10.7507/1671-6205.202209065

Video：

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Objective To explore the association between cough patterns and cerebrovascular disease risk, and to provide epidemiological evidence for the early diagnosis and prevention of cerebrovascular disease. Methods During the period from 2010 to 2012 in Guizhou Province, a multi-stage proportional stratified cluster sampling method was used to recruit people with the inclusion criteria of the study into a cohort and a baseline questionnaire for demographic information, lifestyle, and disease history was administered. The incidence of cerebrovascular disease was followed up from 2016 to 2020. Results A total of 4804 subjects were followed up, and 4589 (53.5% were female) subjects were enrolled in final investigation. Compared with non-chronic cough group, there was no statistical significance in the risk of cerebrovascular diseases (P>0.05), however, chronic cough (the risk ratio was 2.00 and the 95% confidence interval ranged from 1.08 to 3.69) was twice as likely to develop cerebrovascular disease as non-cough. Conclusions People with chronic cough are more likely to develop cerebrovascular disease than people without cough. More attention to the management and control of cough should be paid to avoid chronic cough, so as to reduce the risk of cerebrovascular diseases.

Citation： ZHU Zhenbin, YANG Xiaoxia, CHEN Min, LIU Tao, TIAN Kunming, DENG Renli. Chronic cough and risk of cerebrovascular disease: a prospective cohort study. Chinese Journal of Respiratory and Critical Care Medicine, 2023, 22(5): 343-348. doi: 10.7507/1671-6205.202209065 Copy

1.	金建秋, 李偉, 母艷蕾, 等. 腦血管病患者出現口腔黏膜病的調查分析. 中華流行病學雜志, 2019, 40(8): 1003-1005.
2.	中華醫學會神經病學分會, 中華醫學會神經病學分會腦血管病學組. 中國腦血管疾病分類2015. 中華神經科雜志, 2017, 50(3): 168-171.
3.	彭琴, 李海玲, 王媛, 等. 1990-2016年中國人群腦血管病疾病負擔變化趨勢. 中華流行病學雜志, 2019, 40(4): 400-405.
4.	錢丹, 潘華, 劉維洲, 等. 2016—2018年銅陵市心腦血管疾病死亡及潛在減壽情況分析. 中國公共衛生管理, 2021, 37(4): 494-497+505.
5.	The GBD 2016 Lifetime Risk of Stroke Collaborators; Feigin VL, Nguyen G, Cercy K, et al. Global, Regional, and Country-Specific Lifetime Risks of Stroke, 1990 and 2016. N Engl J Med, 2018, 379(25): 2429-2437.
6.	Ma QF, Li R, Wang LJ, et al. Temporal trend and attributable risk factors of stroke burden in China, 1990-2019: an analysis for the Global Burden of Disease Study 2019. Lancet Public Health, 2021, 6(12): e897-e906.
7.	Wu SM, Wu B, Liu M, et al. Stroke in China: advances and challenges in epidemiology, prevention, and management. Lancet Neurol, 2019, 18(4): 394–405.
8.	Chao BH, Yan F, Hua Y, et al. Stroke prevention and control system in China: CSPPC-Stroke Program. Int J Stroke, 2021, 16(3): 265-272.
9.	王擁軍, 李子孝, 谷鴻秋, 等. 中國卒中報告2019(中文版)(3). 中國卒中雜志, 2020, 15(12): 1251-1263.
10.	McGarvey L, Gibson PG. What is chronic cough? Terminology. J Allergy Clin Immunol Pract, 2019, 7(6): 1711-1714.
11.	劉英麗. 咳嗽性暈厥病因及發病機制探究[D]. 鄭州大學, 2018.
12.	楊中華. Neurology: 咳嗽誘發持續性高顱壓. 中國卒中雜志, 2019, 14(10): 1045-1046.
13.	Feary JR, Rodrigues LC, Smith CJ, et al. Prevalence of major comorbidities in subjects with COPD and incidence of myocardial infarction and stroke: a comprehensive analysis using data from primary care. Thorax, 2010, 65(11): 956-962.
14.	Stavem K, Schirmer H, Gulsvik A. Respiratory symptoms and cardiovascular causes of deaths: a population-based study with 45 years of follow-up. PLoS One, 2022, 17(10): e0276560.
15.	吉寧飛, 蔣雄斌, 黃茂. 老年人慢性咳嗽的病因構成和臨床分析. 實用老年醫學, 2012, 26(5): 377-379.
16.	王麗敏, 張梅, 李鎰沖, 等. 2013年中國慢性病及其危險因素監測總體方案. 中華預防醫學雜志, 2018, 52(2): 191-194.
17.	趙文華, 寧光. 2010年中國慢性病監測項目的內容與方法. 中華預防醫學雜志, 2012, 46(5): 477-479.
18.	《中國腦卒中防治報告2019》編寫組. 《中國腦卒中防治報告2019》概要. 中國腦血管病雜志, 2020, 17(5): 272-281.
19.	《中國高血壓防治指南》修訂委員會. 中國高血壓防治指南2018年修訂版. 心腦血管病防治, 2019, 19(1): 1-44.
20.	中國成人血脂異常防治指南修訂聯合委員會. 中國成人血脂異常防治指南(2016年修訂版). 中華健康管理學雜志, 2017, 11(1): 7-28.
21.	De Torres JP, Cordoba-Lanus E, López-Aguilar C, et al. C-reactive protein levels and clinically important predictive outcomes in stable COPD patients. Eur Respir J, 2006, 27(5): 902-907.
22.	Morgan AD, Zakeri R, Quint JK. Defining the relationship between COPD and CVD: what are the implications for clinical practice?. Ther Adv Respir Dis, 2018, 12: 1753465817750524.
23.	Austin V, Crack PJ, Bozinovski S, et al. COPD and stroke: are systemic inflammation and oxidative stress the missing links?. Clin Sci (Lond), 2016, 130(13): 1039-1050.
24.	Swystun LL, Liaw PC. The role of leukocytes in thrombosis. Blood, 2016, 128(6): 753-762.
25.	陸子華. 高血壓是怎么引起腦梗死的. 人人健康, 2021(23): 25.
26.	Imano H, Kitamura A, Sato S, et al. Trends for blood pressure and its contribution to stroke incidence in the middle-aged Japanese population: the Circulatory Risk in Communities Study (CIRCS). Stroke, 2009, 40(5): 1571-1577.
27.	Melbye H, Stylidis M, Solis JCA, et al. Prediction of chronic heart failure and chronic obstructive pulmonary disease in a general population: the Troms? study. ESC Heart Fail, 2020, 7(6): 4139-4150.
28.	Lahousse L, Verhamme KM, Stricker BH, et al. Cardiac effects of current treatments of chronic obstructive pulmonary disease. Lancet Respir Med, 2016, 4(2): 149-164.
29.	張涵泊, 周卓星. 腦血管病診治中血脂檢驗的應用效果研究. 微量元素與健康研究, 2022, 39(1): 71-72.

1. 金建秋, 李偉, 母艷蕾, 等. 腦血管病患者出現口腔黏膜病的調查分析. 中華流行病學雜志, 2019, 40(8): 1003-1005.
2. 中華醫學會神經病學分會, 中華醫學會神經病學分會腦血管病學組. 中國腦血管疾病分類2015. 中華神經科雜志, 2017, 50(3): 168-171.
3. 彭琴, 李海玲, 王媛, 等. 1990-2016年中國人群腦血管病疾病負擔變化趨勢. 中華流行病學雜志, 2019, 40(4): 400-405.
4. 錢丹, 潘華, 劉維洲, 等. 2016—2018年銅陵市心腦血管疾病死亡及潛在減壽情況分析. 中國公共衛生管理, 2021, 37(4): 494-497+505.
5. The GBD 2016 Lifetime Risk of Stroke Collaborators; Feigin VL, Nguyen G, Cercy K, et al. Global, Regional, and Country-Specific Lifetime Risks of Stroke, 1990 and 2016. N Engl J Med, 2018, 379(25): 2429-2437.
6. Ma QF, Li R, Wang LJ, et al. Temporal trend and attributable risk factors of stroke burden in China, 1990-2019: an analysis for the Global Burden of Disease Study 2019. Lancet Public Health, 2021, 6(12): e897-e906.
7. Wu SM, Wu B, Liu M, et al. Stroke in China: advances and challenges in epidemiology, prevention, and management. Lancet Neurol, 2019, 18(4): 394–405.
8. Chao BH, Yan F, Hua Y, et al. Stroke prevention and control system in China: CSPPC-Stroke Program. Int J Stroke, 2021, 16(3): 265-272.
9. 王擁軍, 李子孝, 谷鴻秋, 等. 中國卒中報告2019(中文版)(3). 中國卒中雜志, 2020, 15(12): 1251-1263.
10. McGarvey L, Gibson PG. What is chronic cough? Terminology. J Allergy Clin Immunol Pract, 2019, 7(6): 1711-1714.
11. 劉英麗. 咳嗽性暈厥病因及發病機制探究[D]. 鄭州大學, 2018.
12. 楊中華. Neurology: 咳嗽誘發持續性高顱壓. 中國卒中雜志, 2019, 14(10): 1045-1046.
13. Feary JR, Rodrigues LC, Smith CJ, et al. Prevalence of major comorbidities in subjects with COPD and incidence of myocardial infarction and stroke: a comprehensive analysis using data from primary care. Thorax, 2010, 65(11): 956-962.
14. Stavem K, Schirmer H, Gulsvik A. Respiratory symptoms and cardiovascular causes of deaths: a population-based study with 45 years of follow-up. PLoS One, 2022, 17(10): e0276560.
15. 吉寧飛, 蔣雄斌, 黃茂. 老年人慢性咳嗽的病因構成和臨床分析. 實用老年醫學, 2012, 26(5): 377-379.
16. 王麗敏, 張梅, 李鎰沖, 等. 2013年中國慢性病及其危險因素監測總體方案. 中華預防醫學雜志, 2018, 52(2): 191-194.
17. 趙文華, 寧光. 2010年中國慢性病監測項目的內容與方法. 中華預防醫學雜志, 2012, 46(5): 477-479.
18. 《中國腦卒中防治報告2019》編寫組. 《中國腦卒中防治報告2019》概要. 中國腦血管病雜志, 2020, 17(5): 272-281.
19. 《中國高血壓防治指南》修訂委員會. 中國高血壓防治指南2018年修訂版. 心腦血管病防治, 2019, 19(1): 1-44.
20. 中國成人血脂異常防治指南修訂聯合委員會. 中國成人血脂異常防治指南(2016年修訂版). 中華健康管理學雜志, 2017, 11(1): 7-28.
21. De Torres JP, Cordoba-Lanus E, López-Aguilar C, et al. C-reactive protein levels and clinically important predictive outcomes in stable COPD patients. Eur Respir J, 2006, 27(5): 902-907.
22. Morgan AD, Zakeri R, Quint JK. Defining the relationship between COPD and CVD: what are the implications for clinical practice?. Ther Adv Respir Dis, 2018, 12: 1753465817750524.
23. Austin V, Crack PJ, Bozinovski S, et al. COPD and stroke: are systemic inflammation and oxidative stress the missing links?. Clin Sci (Lond), 2016, 130(13): 1039-1050.
24. Swystun LL, Liaw PC. The role of leukocytes in thrombosis. Blood, 2016, 128(6): 753-762.
25. 陸子華. 高血壓是怎么引起腦梗死的. 人人健康, 2021(23): 25.
26. Imano H, Kitamura A, Sato S, et al. Trends for blood pressure and its contribution to stroke incidence in the middle-aged Japanese population: the Circulatory Risk in Communities Study (CIRCS). Stroke, 2009, 40(5): 1571-1577.
27. Melbye H, Stylidis M, Solis JCA, et al. Prediction of chronic heart failure and chronic obstructive pulmonary disease in a general population: the Troms? study. ESC Heart Fail, 2020, 7(6): 4139-4150.
28. Lahousse L, Verhamme KM, Stricker BH, et al. Cardiac effects of current treatments of chronic obstructive pulmonary disease. Lancet Respir Med, 2016, 4(2): 149-164.
29. 張涵泊, 周卓星. 腦血管病診治中血脂檢驗的應用效果研究. 微量元素與健康研究, 2022, 39(1): 71-72.

Chinese Journal of Respiratory and Critical Care Medicine

Chronic cough and risk of cerebrovascular disease: a prospective cohort study

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