Comparative analysis of related indexes of obstructive sleep apnea hypopnea syndrome between Chinese Uighur and Han patients_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

WU Yuan ¹ , CHEN Xueru ¹ , WU Siyi ¹ , CHEN Jiankun ² , ZHENG Aifang ⁴ ,  LI Li ⁴ ,  LI Jiqiang ² ,  CHEN Hai ³

1. The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, P. R. China;
2. The Third General Department, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, Guangdong 510006, P. R. China;
3. Department of Otolaryngology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, Guangdong 510006, P. R. China;
4. Department of Respiratory and Critical Care Medicine, Kashi First People's Hospital, Kashi, Xinjiang 844000, P. R. China;

Corresponding?author：

LI Li, Email: 811346876@qq.com; LI Jiqiang, Email: lijiqiangjizhen@163.com; CHEN Hai, Email: chaitcm@163.com

Keywords：

Obstructive sleep apnea hypopnea syndrome; Han nationality; Uygur nationality; disease characteristics

DOI：

10.7507/1671-6205.202304042

Video：

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Objective To study the differences of obstructive sleep apnea hypopnea syndrome (OSAHS)-related indexes between Uyghur and Han, and to provide evidence for the development of individualized treatment measures for different ethnic groups. Methods 224 Han OSAHS patients were collected from Guangdong Provincial Hospital of Chinese Medicine, and 178 Uygur OSAHS patients were collected from The First People’s Hospital of Kashi between January 2018 and December 2019. The collected data information included age, sex, nationality, body mass index (BMI), apnea hypopnea index (AHI), lowest oxygen saturation (LSaO₂), OSAHS stage, mean corpuscular hemoglobin concentration (MCHC), triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), fasting blood glucose (FBG), and glycosylated hemoglobin (HbAlc). After using propensity matching scores to reduce confounding factors, differences in above indicators between different nationalities were compared. Results The mean values of MCHC, TC and HDL in Uygur OSAHS patients were lower than those in Han patients at the same stage, and the mean values of LSaO₂ and LDL in mild and severe Uygur OSAHS patients were lower than those in Han patients at the same stage, with statistically significant differences (all P<0.05). There were no significant differences in AHI, TG, FBG or HbAlc between Uygur and Han patients with OSAHS. Conclusion There are significant differences in LSaO₂, LDL, MCHC, TC and HDL between Uygur and Han Chinese patients with OSAHS.

Citation： WU Yuan, CHEN Xueru, WU Siyi, CHEN Jiankun, ZHENG Aifang, LI Li, LI Jiqiang, CHEN Hai. Comparative analysis of related indexes of obstructive sleep apnea hypopnea syndrome between Chinese Uighur and Han patients. Chinese Journal of Respiratory and Critical Care Medicine, 2023, 22(6): 424-430. doi: 10.7507/1671-6205.202304042 Copy

1.	伍瑜, 佘笠, 黃東海. 阻塞性睡眠呼吸暫停低通氣綜合征患者相關免疫功能變化的研究進展. 中華耳鼻咽喉頭頸外科雜志, 2022, 57(5): 649-655.
2.	Malhotra A, White DP. Obstructive sleep apnoea. Lancet, 2002, 360(9328): 237-245.
3.	Lu XX, Wang X, Xu T, et al. Circulating C3 and glucose metabolism abnormalities in patients with OSAHS. Sleep Breath, 2018, 22(2): 345-351.
4.	White DP. Pathogenesis of obstructive and central sleep apnea. Am J Respir Crit Care Med, 2005, 172(11): 1363-1370.
5.	游振寧, 楊青巖. 阻塞性睡眠呼吸暫停綜合征與動脈粥樣硬化研究進展. 臨床醫學進展, 2022, 12(8): 7284-7291.
6.	Parikh MP, Gupta NM, Mccullough AJ. Obstructive sleep apnea and the liver. Clin Liver Dis, 2019, 23(2): 363-382.
7.	Franklin KA, Lindberg E. Obstructive sleep apnea is a common disorder in the population - a review on the epidemiology of sleep apnea. J Thorac Dis, 2015, 7(8): 1311-1322.
8.	Berry RB, Budhiraja R, Gottlieb DJ, et al. Rules for scoring respiratory events in sleep: update of the 2007 AASM Manual for the Scoring of Sleep and Associated Events. Deliberations of the Sleep Apnea Definitions Task Force of the American Academy of Sleep Medicine. J Clin Sleep Med, 2012, 8(5): 597-619.
9.	Lévy P, Pépin JL, Arnaud C, et al. Intermittent hypoxia and sleep-disordered breathing: current concepts and perspectives. Eur Respir J, 2008, 32(4): 1082-1095.
10.	Peppard PE, Young T, Barnet JH, et al. Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol, 2013, 177(9): 1006-1014.
11.	Young T, Skatrud J, Peppard PE. Risk factors for obstructive sleep apnea in adults. JAMA, 2004, 291(16): 2013-2016.
12.	李海洲, 李巍, 那學武, 等. 成人阻塞性睡眠呼吸暫停低通氣綜合征患者的人格特征分析. 中國耳鼻咽喉頭頸外科, 2021, 28(1): 49-52.
13.	Punjabi NM. The epidemiology of adult obstructive sleep apnea. Proc Am Thorac Soc, 2008, 5(2): 136-143.
14.	何忠明, 韓芳, 宋鎮, 等. 克拉瑪依市區35歲以上人群鼾癥發生率調查及危險因素分析. 中國呼吸與危重監護雜志, 2010, 9(4): 404-408.
15.	Aurora RN, Punjabi NM. Obstructive sleep apnoea and type 2 diabetes mellitus: a bidirectional association. Lancet Respir Med, 2013, 1(4): 329-338.
16.	楊晰珺, 關建, 吳海鶯. 阻塞性睡眠呼吸暫停低通氣綜合征與血脂紊亂關系的研究進展. 山東大學耳鼻喉眼學報, 2022, 36(2): 133-138.
17.	董文平, 任壽安. 血清核轉錄因子紅系2相關因子2、血紅素加氧酶-1水平與阻塞性睡眠呼吸暫停患者認知障礙的相關性研究. 中國呼吸與危重監護雜志, 2022, 21(7): 478-483.
18.	劉頤軒, 宋桉, 王蕓, 等. 氧化應激在肥胖及胰島素抵抗中的作用研究進展. 解放軍醫藥雜志, 2014, 26(1): 99-101.
19.	周驍, 楊會篤, 蘇葉馨, 等. 氧化應激促進AGT-REN雙轉基因高血壓小鼠心肌中電導鈣激活鉀離子通道表達. 中國病理生理雜志, 2016, 32(5): 869-873.
20.	姜良征, 歐陽松云, 蘇皎. p22phox C242T基因多態性與阻塞性睡眠呼吸暫停并認知功能障礙的關系探討. 中國呼吸與危重監護雜志, 2018, 17(4): 373-376.
21.	王偉. 新疆巴州地區維吾爾族和中原漢族成人下頜部測量分析[D]. 鄭州大學, 2019.
22.	Liak C, Fitzpatrick M. Coagulability in obstructive sleep apnea. Can Respir J, 2011, 18(6): 338-348.
23.	瑪依拉·阿布都克力木. 膽固醇吸收關鍵基因Numb與冠心病及血脂水平的關聯分析研究[D]. 新疆醫科大學, 2016.

1. 伍瑜, 佘笠, 黃東海. 阻塞性睡眠呼吸暫停低通氣綜合征患者相關免疫功能變化的研究進展. 中華耳鼻咽喉頭頸外科雜志, 2022, 57(5): 649-655.
2. Malhotra A, White DP. Obstructive sleep apnoea. Lancet, 2002, 360(9328): 237-245.
3. Lu XX, Wang X, Xu T, et al. Circulating C3 and glucose metabolism abnormalities in patients with OSAHS. Sleep Breath, 2018, 22(2): 345-351.
4. White DP. Pathogenesis of obstructive and central sleep apnea. Am J Respir Crit Care Med, 2005, 172(11): 1363-1370.
5. 游振寧, 楊青巖. 阻塞性睡眠呼吸暫停綜合征與動脈粥樣硬化研究進展. 臨床醫學進展, 2022, 12(8): 7284-7291.
6. Parikh MP, Gupta NM, Mccullough AJ. Obstructive sleep apnea and the liver. Clin Liver Dis, 2019, 23(2): 363-382.
7. Franklin KA, Lindberg E. Obstructive sleep apnea is a common disorder in the population - a review on the epidemiology of sleep apnea. J Thorac Dis, 2015, 7(8): 1311-1322.
8. Berry RB, Budhiraja R, Gottlieb DJ, et al. Rules for scoring respiratory events in sleep: update of the 2007 AASM Manual for the Scoring of Sleep and Associated Events. Deliberations of the Sleep Apnea Definitions Task Force of the American Academy of Sleep Medicine. J Clin Sleep Med, 2012, 8(5): 597-619.
9. Lévy P, Pépin JL, Arnaud C, et al. Intermittent hypoxia and sleep-disordered breathing: current concepts and perspectives. Eur Respir J, 2008, 32(4): 1082-1095.
10. Peppard PE, Young T, Barnet JH, et al. Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol, 2013, 177(9): 1006-1014.
11. Young T, Skatrud J, Peppard PE. Risk factors for obstructive sleep apnea in adults. JAMA, 2004, 291(16): 2013-2016.
12. 李海洲, 李巍, 那學武, 等. 成人阻塞性睡眠呼吸暫停低通氣綜合征患者的人格特征分析. 中國耳鼻咽喉頭頸外科, 2021, 28(1): 49-52.
13. Punjabi NM. The epidemiology of adult obstructive sleep apnea. Proc Am Thorac Soc, 2008, 5(2): 136-143.
14. 何忠明, 韓芳, 宋鎮, 等. 克拉瑪依市區35歲以上人群鼾癥發生率調查及危險因素分析. 中國呼吸與危重監護雜志, 2010, 9(4): 404-408.
15. Aurora RN, Punjabi NM. Obstructive sleep apnoea and type 2 diabetes mellitus: a bidirectional association. Lancet Respir Med, 2013, 1(4): 329-338.
16. 楊晰珺, 關建, 吳海鶯. 阻塞性睡眠呼吸暫停低通氣綜合征與血脂紊亂關系的研究進展. 山東大學耳鼻喉眼學報, 2022, 36(2): 133-138.
17. 董文平, 任壽安. 血清核轉錄因子紅系2相關因子2、血紅素加氧酶-1水平與阻塞性睡眠呼吸暫停患者認知障礙的相關性研究. 中國呼吸與危重監護雜志, 2022, 21(7): 478-483.
18. 劉頤軒, 宋桉, 王蕓, 等. 氧化應激在肥胖及胰島素抵抗中的作用研究進展. 解放軍醫藥雜志, 2014, 26(1): 99-101.
19. 周驍, 楊會篤, 蘇葉馨, 等. 氧化應激促進AGT-REN雙轉基因高血壓小鼠心肌中電導鈣激活鉀離子通道表達. 中國病理生理雜志, 2016, 32(5): 869-873.
20. 姜良征, 歐陽松云, 蘇皎. p22phox C242T基因多態性與阻塞性睡眠呼吸暫停并認知功能障礙的關系探討. 中國呼吸與危重監護雜志, 2018, 17(4): 373-376.
21. 王偉. 新疆巴州地區維吾爾族和中原漢族成人下頜部測量分析[D]. 鄭州大學, 2019.
22. Liak C, Fitzpatrick M. Coagulability in obstructive sleep apnea. Can Respir J, 2011, 18(6): 338-348.
23. 瑪依拉·阿布都克力木. 膽固醇吸收關鍵基因Numb與冠心病及血脂水平的關聯分析研究[D]. 新疆醫科大學, 2016.

Chinese Journal of Respiratory and Critical Care Medicine

Comparative analysis of related indexes of obstructive sleep apnea hypopnea syndrome between Chinese Uighur and Han patients

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