治療性間歇低氧–高氧研究進展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

何陽 , 王易軒 ,  胡克

武漢大學人民醫院呼吸與危重癥醫學二科（湖北武漢 430060）;

Corresponding?author：

胡克, Email: hukejx@163.com

Keywords：

DOI：

10.7507/1671-6205.202307023

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Citation： 何陽, 王易軒, 胡克. 治療性間歇低氧–高氧研究進展. Chinese Journal of Respiratory and Critical Care Medicine, 2023, 22(11): 815-820. doi: 10.7507/1671-6205.202307023 Copy

1.	Hamlin MJ, Lizamore CA, Hopkins WG. The effect of natural or simulated altitude training on high-intensity intermittent running performance in team-sport athletes: a meta-analysis. Sports Med, 2018, 48(2): 431-446.
2.	Schega L, Peter B, Brigadski T, et al. Effect of intermittent normobaric hypoxia on aerobic capacity and cognitive function in older people. J Sci Med Sport, 2016, 19(11): 941-945.
3.	Mateika JH, El-Chami M, Shaheen D, et al. Intermittent hypoxia: a low-risk research tool with therapeutic value in humans. J Appl Physiol (1985), 2015, 118(5): 520-532.
4.	Navarrete-Opazo A, Mitchell GS. Therapeutic potential of intermittent hypoxia: a matter of dose. Am J Physiol Regul Integr Comp Physiol, 2014, 307(10): R1181-R1197.
5.	Shobatake R, Ota H, Takahashi N, et al. The impact of intermittent hypoxia on metabolism and cognition. Int J Mol Sci, 2022, 23(21): 12957.
6.	查世乾, 陳豪, 郝玥影, 等. 急性間歇低氧暴露對心肺功能的影響. 中華結核和呼吸雜志, 2023, 46(3): 257-262.
7.	Panza GS, Puri S, Lin HS, et al. Daily exposure to mild intermittent hypoxia reduces blood pressure in male patients with obstructive sleep apnea and hypertension. Am J Respir Crit Care Med, 2022, 205(8): 949-958.
8.	Brugniaux JV, Pialoux V, Foster GE, et al. Effects of intermittent hypoxia on erythropoietin, soluble erythropoietin receptor and ventilation in humans. Eur Respir J, 2011, 37(4): 880-887.
9.	Wang H, Shi XR, Schenck H, et al. Intermittent hypoxia training for treating mild cognitive impairment: a pilot study. Am J Alzheimers Dis Other Demen, 2020, 35: 1533317519896725.
10.	Semenza GL. Oxygen sensing, homeostasis, and disease. N Engl J Med, 2011, 365(6): 537-547.
11.	Shohet RV, Garcia JA. Keeping the engine primed: Hif factors as key regulators of cardiac metabolism and angiogenesis during ischemia. J Mol Med (Berl), 2007, 85(12): 1309-1315.
12.	Wojan F, Stray-Gundersen S, Nagel MJ, et al. Short exposure to intermittent hypoxia increases erythropoietin levels in healthy individuals. J Appl Physiol (1985), 2021, 130(6): 1955-1960.
13.	Tobin B, Costalat G, Renshaw GMC. Intermittent not continuous hypoxia provoked haematological adaptations in healthy seniors: hypoxic pattern may hold the key. Eur J Appl Physiol, 2020, 120(3): 707-718.
14.	Serebrovska TV, Portnychenko AG, Drevytska TI, et al. Intermittent hypoxia training in prediabetes patients: Beneficial effects on glucose homeostasis, hypoxia tolerance and gene expression. Exp Biol Med (Maywood), 2017, 242(15): 1542-1552.
15.	Lyamina NP, Lyamina SV, Senchiknin VN, et al. Normobaric hypoxia conditioning reduces blood pressure and normalizes nitric oxide synthesis in patients with arterial hypertension. J Hypertens, 2011, 29(11): 2265-2272.
16.	Millet GP, Debevec T, Brocherie F, et al. Therapeutic use of exercising in hypoxia: Promises and limitations. Front Physiol, 2016, 7: 224.
17.	Serebrovska TV, Grib ON, Portnichenko VI, et al. Intermittent hypoxia/hyperoxia versus intermittent hypoxia/normoxia: comparative study in prediabetes. High Alt Med Biol, 2019, 20(4): 383-391.
18.	Brinkmann C, Metten A, Scriba P, et al. Hypoxia and hyperoxia affect serum angiogenic regulators in t2dm men during cycling. Int J Sports Med, 2017, 38(2): 92-98.
19.	Serebrovskaya TV, Xi L. Intermittent hypoxia training as non-pharmacologic therapy for cardiovascular diseases: practical analysis on methods and equipment. Exp Biol Med (Maywood), 2016, 241(15): 1708-1723.
20.	Treml B, Gatterer H, Burtscher J, et al. A focused review on the maximal exercise responses in hypo- and normobaric hypoxia: divergent oxygen uptake and ventilation responses. Int J Environ Res Public Health, 2020, 17(14): 5239.
21.	Afina AB, Oleg SG, Alexander AB, et al. The effects of intermittent hypoxic-hyperoxic exposures on lipid profile and inflammation in patients with metabolic syndrome. Front Cardiovasc Med, 2021, 8: 700826.
22.	Behrendt T, Altorjay AC, Bielitzki R, et al. Influence of acute and chronic intermittent hypoxic-hyperoxic exposure prior to aerobic exercise on cardiovascular risk factors in geriatric patients - a randomized controlled trial. Front Physiol, 2022, 13: 1043536.
23.	Behrendt T, Bielitzki R, Behrens M, et al. Effects of intermittent hypoxia-hyperoxia exposure prior to aerobic cycling exercise on physical and cognitive performance in geriatric patients - a randomized controlled trial. Front Physiol, 2022, 13: 899096.
24.	Bestavashvili A, Glazachev O, Bestavashvili A, et al. Intermittent hypoxic-hyperoxic exposures effects in patients with metabolic syndrome: correction of cardiovascular and metabolic profile. Biomedicines, 2022, 10(3): 566.
25.	Dudnik E, Zagaynaya E, Glazachev OS, et al. Intermittent hypoxia-hyperoxia conditioning improves cardiorespiratory fitness in older comorbid cardiac outpatients without hematological changes: a randomized controlled trial. High Alt Med Biol, 2018, 19(4): 339-343.
26.	Glazachev O, Kopylov P, Susta D, et al. Adaptations following an intermittent hypoxia-hyperoxia training in coronary artery disease patients: a controlled study. Clin Cardiol, 2017, 40(6): 370-376.
27.	Glazachev OS, Dudnik EN, Zapara MA, et al. Adaptation to dosed hypoxia-hyperoxia as a factor in improving the quality of life of elderly patients with cardiac pathology. Adv Gerontol, 2019, 32(1-2): 145-151.
28.	Syrkin AL, Glazachev OS, Kopylov FY, et al. Adaptation to intermittent hypoxia-hyperoxia in the rehabilitation of patients with ischemic heart disease: exercise tolerance and quality of life. Kardiologiia, 2017, 57(5): 10-16.
29.	Bayer U, Glazachev OS, Likar R, et al. Adaptation to intermittent hypoxia-hyperoxia improves cognitive performance and exercise tolerance in elderly. Adv Gerontol, 2017, 30(2): 255-261.
30.	Serebrovska ZO, Serebrovska TV, Kholin VA, et al. Intermittent hypoxia-hyperoxia training improves cognitive function and decreases circulating biomarkers of alzheimer's disease in patients with mild cognitive impairment: a pilot study. Int J Mol Sci, 2019, 20(21): 5405.
31.	Serebrovska ZO, Xi L, Tumanovska LV, et al. Response of circulating inflammatory markers to intermittent hypoxia-hyperoxia training in healthy elderly people and patients with mild cognitive impairment. Life (Basel), 2022, 12(3): 432.
32.	Burtscher J, Mallet RT, Burtscher M, et al. Hypoxia and brain aging: Neurodegeneration or neuroprotection? Ageing Res Rev, 2021, 68: 101343.
33.	Iyalomhe O, Swierczek S, Enwerem N, et al. The role of hypoxia-inducible factor 1 in mild cognitive impairment. Cell Mol Neurobiol, 2017, 37(6): 969-977.
34.	Zenaro E, Pietronigro E, Della Bianca V, et al. Neutrophils promote alzheimer's disease-like pathology and cognitive decline via lfa-1 integrin. Nat Med, 2015, 21(8): 880-886.
35.	Swank AM, Horton J, Fleg JL, et al. Modest increase in peak vo2 is related to better clinical outcomes in chronic heart failure patients: results from heart failure and a controlled trial to investigate outcomes of exercise training. Circ Heart Fail, 2012, 5(5): 579-585.
36.	Serebrovskaya TV, Manukhina EB, Smith ML, et al. Intermittent hypoxia: Cause of or therapy for systemic hypertension? Exp Biol Med (Maywood), 2008, 233(6): 627-650.
37.	Paniagua OA, Bryant MB, Panza JA. Role of endothelial nitric oxide in shear stress-induced vasodilation of human microvasculature: diminished activity in hypertensive and hypercholesterolemic patients. Circulation, 2001, 103(13): 1752-1758.
38.	Vedam H, Phillips CL, Wang D, et al. Short-term hypoxia reduces arterial stiffness in healthy men. Eur J Appl Physiol, 2009, 105(1): 19-25.
39.	Fuchs FD, Whelton PK. High blood pressure and cardiovascular disease. Hypertension, 2020, 75(2): 285-292.
40.	Lewington S, Clarke R, Qizilbash N, et al. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet, 2002, 360(9349): 1903-1913.
41.	Zhang PZ, Downey HF, Chen SD, et al. Two-week normobaric intermittent hypoxia exposures enhance oxyhemoglobin equilibrium and cardiac responses during hypoxemia. Am J Physiol Regul Integr Comp Physiol, 2014, 307(6): R721-R730.
42.	Debevec T. Hypoxia-related hormonal appetite modulation in humans during rest and exercise: Mini review. Front Physiol, 2017, 8: 366.
43.	O'Hagan KA, Cocchiglia S, Zhdanov AV, et al. Pgc-1alpha is coupled to hif-1alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells. Proc Natl Acad Sci U S A, 2009, 106(7): 2188-2193.
44.	Kim SW, Jung WS, Chung S, et al. Exercise intervention under hypoxic condition as a new therapeutic paradigm for type 2 diabetes mellitus: a narrative review. World J Diabetes, 2021, 12(4): 331-343.
45.	van Hulten V, van Meijel RLJ, Goossens GH. The impact of hypoxia exposure on glucose homeostasis in metabolically compromised humans: a systematic review. Rev Endocr Metab Disord, 2021, 22(2): 471-483.
46.	van Meijel RLJ, Vogel MAA, Jocken JWE, et al. Mild intermittent hypoxia exposure induces metabolic and molecular adaptations in men with obesity. Mol Metab, 2021, 53: 101287.

1. Hamlin MJ, Lizamore CA, Hopkins WG. The effect of natural or simulated altitude training on high-intensity intermittent running performance in team-sport athletes: a meta-analysis. Sports Med, 2018, 48(2): 431-446.
2. Schega L, Peter B, Brigadski T, et al. Effect of intermittent normobaric hypoxia on aerobic capacity and cognitive function in older people. J Sci Med Sport, 2016, 19(11): 941-945.
3. Mateika JH, El-Chami M, Shaheen D, et al. Intermittent hypoxia: a low-risk research tool with therapeutic value in humans. J Appl Physiol (1985), 2015, 118(5): 520-532.
4. Navarrete-Opazo A, Mitchell GS. Therapeutic potential of intermittent hypoxia: a matter of dose. Am J Physiol Regul Integr Comp Physiol, 2014, 307(10): R1181-R1197.
5. Shobatake R, Ota H, Takahashi N, et al. The impact of intermittent hypoxia on metabolism and cognition. Int J Mol Sci, 2022, 23(21): 12957.
6. 查世乾, 陳豪, 郝玥影, 等. 急性間歇低氧暴露對心肺功能的影響. 中華結核和呼吸雜志, 2023, 46(3): 257-262.
7. Panza GS, Puri S, Lin HS, et al. Daily exposure to mild intermittent hypoxia reduces blood pressure in male patients with obstructive sleep apnea and hypertension. Am J Respir Crit Care Med, 2022, 205(8): 949-958.
8. Brugniaux JV, Pialoux V, Foster GE, et al. Effects of intermittent hypoxia on erythropoietin, soluble erythropoietin receptor and ventilation in humans. Eur Respir J, 2011, 37(4): 880-887.
9. Wang H, Shi XR, Schenck H, et al. Intermittent hypoxia training for treating mild cognitive impairment: a pilot study. Am J Alzheimers Dis Other Demen, 2020, 35: 1533317519896725.
10. Semenza GL. Oxygen sensing, homeostasis, and disease. N Engl J Med, 2011, 365(6): 537-547.
11. Shohet RV, Garcia JA. Keeping the engine primed: Hif factors as key regulators of cardiac metabolism and angiogenesis during ischemia. J Mol Med (Berl), 2007, 85(12): 1309-1315.
12. Wojan F, Stray-Gundersen S, Nagel MJ, et al. Short exposure to intermittent hypoxia increases erythropoietin levels in healthy individuals. J Appl Physiol (1985), 2021, 130(6): 1955-1960.
13. Tobin B, Costalat G, Renshaw GMC. Intermittent not continuous hypoxia provoked haematological adaptations in healthy seniors: hypoxic pattern may hold the key. Eur J Appl Physiol, 2020, 120(3): 707-718.
14. Serebrovska TV, Portnychenko AG, Drevytska TI, et al. Intermittent hypoxia training in prediabetes patients: Beneficial effects on glucose homeostasis, hypoxia tolerance and gene expression. Exp Biol Med (Maywood), 2017, 242(15): 1542-1552.
15. Lyamina NP, Lyamina SV, Senchiknin VN, et al. Normobaric hypoxia conditioning reduces blood pressure and normalizes nitric oxide synthesis in patients with arterial hypertension. J Hypertens, 2011, 29(11): 2265-2272.
16. Millet GP, Debevec T, Brocherie F, et al. Therapeutic use of exercising in hypoxia: Promises and limitations. Front Physiol, 2016, 7: 224.
17. Serebrovska TV, Grib ON, Portnichenko VI, et al. Intermittent hypoxia/hyperoxia versus intermittent hypoxia/normoxia: comparative study in prediabetes. High Alt Med Biol, 2019, 20(4): 383-391.
18. Brinkmann C, Metten A, Scriba P, et al. Hypoxia and hyperoxia affect serum angiogenic regulators in t2dm men during cycling. Int J Sports Med, 2017, 38(2): 92-98.
19. Serebrovskaya TV, Xi L. Intermittent hypoxia training as non-pharmacologic therapy for cardiovascular diseases: practical analysis on methods and equipment. Exp Biol Med (Maywood), 2016, 241(15): 1708-1723.
20. Treml B, Gatterer H, Burtscher J, et al. A focused review on the maximal exercise responses in hypo- and normobaric hypoxia: divergent oxygen uptake and ventilation responses. Int J Environ Res Public Health, 2020, 17(14): 5239.
21. Afina AB, Oleg SG, Alexander AB, et al. The effects of intermittent hypoxic-hyperoxic exposures on lipid profile and inflammation in patients with metabolic syndrome. Front Cardiovasc Med, 2021, 8: 700826.
22. Behrendt T, Altorjay AC, Bielitzki R, et al. Influence of acute and chronic intermittent hypoxic-hyperoxic exposure prior to aerobic exercise on cardiovascular risk factors in geriatric patients - a randomized controlled trial. Front Physiol, 2022, 13: 1043536.
23. Behrendt T, Bielitzki R, Behrens M, et al. Effects of intermittent hypoxia-hyperoxia exposure prior to aerobic cycling exercise on physical and cognitive performance in geriatric patients - a randomized controlled trial. Front Physiol, 2022, 13: 899096.
24. Bestavashvili A, Glazachev O, Bestavashvili A, et al. Intermittent hypoxic-hyperoxic exposures effects in patients with metabolic syndrome: correction of cardiovascular and metabolic profile. Biomedicines, 2022, 10(3): 566.
25. Dudnik E, Zagaynaya E, Glazachev OS, et al. Intermittent hypoxia-hyperoxia conditioning improves cardiorespiratory fitness in older comorbid cardiac outpatients without hematological changes: a randomized controlled trial. High Alt Med Biol, 2018, 19(4): 339-343.
26. Glazachev O, Kopylov P, Susta D, et al. Adaptations following an intermittent hypoxia-hyperoxia training in coronary artery disease patients: a controlled study. Clin Cardiol, 2017, 40(6): 370-376.
27. Glazachev OS, Dudnik EN, Zapara MA, et al. Adaptation to dosed hypoxia-hyperoxia as a factor in improving the quality of life of elderly patients with cardiac pathology. Adv Gerontol, 2019, 32(1-2): 145-151.
28. Syrkin AL, Glazachev OS, Kopylov FY, et al. Adaptation to intermittent hypoxia-hyperoxia in the rehabilitation of patients with ischemic heart disease: exercise tolerance and quality of life. Kardiologiia, 2017, 57(5): 10-16.
29. Bayer U, Glazachev OS, Likar R, et al. Adaptation to intermittent hypoxia-hyperoxia improves cognitive performance and exercise tolerance in elderly. Adv Gerontol, 2017, 30(2): 255-261.
30. Serebrovska ZO, Serebrovska TV, Kholin VA, et al. Intermittent hypoxia-hyperoxia training improves cognitive function and decreases circulating biomarkers of alzheimer's disease in patients with mild cognitive impairment: a pilot study. Int J Mol Sci, 2019, 20(21): 5405.
31. Serebrovska ZO, Xi L, Tumanovska LV, et al. Response of circulating inflammatory markers to intermittent hypoxia-hyperoxia training in healthy elderly people and patients with mild cognitive impairment. Life (Basel), 2022, 12(3): 432.
32. Burtscher J, Mallet RT, Burtscher M, et al. Hypoxia and brain aging: Neurodegeneration or neuroprotection? Ageing Res Rev, 2021, 68: 101343.
33. Iyalomhe O, Swierczek S, Enwerem N, et al. The role of hypoxia-inducible factor 1 in mild cognitive impairment. Cell Mol Neurobiol, 2017, 37(6): 969-977.
34. Zenaro E, Pietronigro E, Della Bianca V, et al. Neutrophils promote alzheimer's disease-like pathology and cognitive decline via lfa-1 integrin. Nat Med, 2015, 21(8): 880-886.
35. Swank AM, Horton J, Fleg JL, et al. Modest increase in peak vo2 is related to better clinical outcomes in chronic heart failure patients: results from heart failure and a controlled trial to investigate outcomes of exercise training. Circ Heart Fail, 2012, 5(5): 579-585.
36. Serebrovskaya TV, Manukhina EB, Smith ML, et al. Intermittent hypoxia: Cause of or therapy for systemic hypertension? Exp Biol Med (Maywood), 2008, 233(6): 627-650.
37. Paniagua OA, Bryant MB, Panza JA. Role of endothelial nitric oxide in shear stress-induced vasodilation of human microvasculature: diminished activity in hypertensive and hypercholesterolemic patients. Circulation, 2001, 103(13): 1752-1758.
38. Vedam H, Phillips CL, Wang D, et al. Short-term hypoxia reduces arterial stiffness in healthy men. Eur J Appl Physiol, 2009, 105(1): 19-25.
39. Fuchs FD, Whelton PK. High blood pressure and cardiovascular disease. Hypertension, 2020, 75(2): 285-292.
40. Lewington S, Clarke R, Qizilbash N, et al. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet, 2002, 360(9349): 1903-1913.
41. Zhang PZ, Downey HF, Chen SD, et al. Two-week normobaric intermittent hypoxia exposures enhance oxyhemoglobin equilibrium and cardiac responses during hypoxemia. Am J Physiol Regul Integr Comp Physiol, 2014, 307(6): R721-R730.
42. Debevec T. Hypoxia-related hormonal appetite modulation in humans during rest and exercise: Mini review. Front Physiol, 2017, 8: 366.
43. O'Hagan KA, Cocchiglia S, Zhdanov AV, et al. Pgc-1alpha is coupled to hif-1alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells. Proc Natl Acad Sci U S A, 2009, 106(7): 2188-2193.
44. Kim SW, Jung WS, Chung S, et al. Exercise intervention under hypoxic condition as a new therapeutic paradigm for type 2 diabetes mellitus: a narrative review. World J Diabetes, 2021, 12(4): 331-343.
45. van Hulten V, van Meijel RLJ, Goossens GH. The impact of hypoxia exposure on glucose homeostasis in metabolically compromised humans: a systematic review. Rev Endocr Metab Disord, 2021, 22(2): 471-483.
46. van Meijel RLJ, Vogel MAA, Jocken JWE, et al. Mild intermittent hypoxia exposure induces metabolic and molecular adaptations in men with obesity. Mol Metab, 2021, 53: 101287.

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Chinese Journal of Respiratory and Critical Care Medicine

治療性間歇低氧–高氧研究進展

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