慢性間歇性低氧導致認知障礙的細胞機制研究進展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

黃惠嫦 ^1,2,3,4 , 文依寧 ^1,2,3,5 ,  梁新 ^2,6 ,  趙明明 ^1,2,3

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2. ;
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5. ;
6. ;

Corresponding?author：

梁新, Email: gxyyliangxin@sina.com; 趙明明, Email: topabigale@163.com

Keywords：

DOI：

10.7507/1671-6205.202405114

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Citation： 黃惠嫦, 文依寧, 梁新, 趙明明. 慢性間歇性低氧導致認知障礙的細胞機制研究進展. Chinese Journal of Respiratory and Critical Care Medicine, 2025, 24(3): 218-224. doi: 10.7507/1671-6205.202405114 Copy

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1. 何權瀛, 陳寶元, 韓芳. 睡眠呼吸病學. 第2版. 北京: 人民衛生出版社, 2022: 4-8.
2. Rae C, Bartlett DJ, Yang Q, et al. Dynamic changes in brain bioenergetics during obstructive sleep apnea. J Cereb Blood Flow Metab, 2009, 29(8): 1421-1428.
3. Mubashir T, Abrahamyan L, Niazi A, et al. The prevalence of obstructive sleep apnea in mild cognitive impairment: a systematic review. BMC Neurol, 2019, 19(1): 195.
4. 覃麗霞, 鐘清清, 陸怡安, 等. 老年阻塞性睡眠呼吸暫停合并認知功能障礙患者睡眠及腦功能狀態特點. 中國臨床新醫學, 2024, 17(1): 12-18.
5. 何權瀛. 阻塞性睡眠呼吸暫停綜合征何權瀛2022觀點. 第1版. 北京: 科學技術文獻出版社, 2022: 28-43.
6. Macey PM, Henderson LA, Macey KE, et al. Brain morphology associated with obstructive sleep apnea. Am J Respir Crit Care Med, 2002, 166(10): 1382-1387.
7. 沈煜斌, 歐茜文, 劉松. 阻塞性睡眠呼吸暫停對腦代謝功能的影響. 中國呼吸與危重監護雜志, 2024, 23(2): 132-137.
8. Yang Q, Wang Y, Feng J, et al. Intermittent hypoxia from obstructive sleep apnea may cause neuronal impairment and dysfunction in central nervous system: the potential roles played by microglia. Neuropsychiatr Dis Treat, 2013, 9: 1077-1086.
9. Nair D, Ramesh V, Li RC, et al. Growth hormone releasing hormone (GHRH) signaling modulates intermittent hypoxia-induced oxidative stress and cognitive deficits in mouse. J Neurochem, 2013, 127(4): 531-540.
10. Aviles-Reyes RX, Angelo MF, Villarreal A, et al. Intermittent hypoxia during sleep induces reactive gliosis and limited neuronal death in rats: implications for sleep apnea. J Neurochem, 2010, 112(4): 854-869.
11. Lewén A, Matz P, Chan PH. Free radical pathways in CNS injury. J Neurotrauma, 2000, 17(10): 871-890.
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