Association of SG13S114 and SG13S32 polymorphisms in <i>ALOX5AP</i> gene and risk of ischemic stroke in Chinese: a meta-analysis _Chinese Journal of Evidence-Based Medicine

Authors：

DAI Huixu , HE Qiao , LI Guangxiao , ZHANG Peng , SUN Hao ,  SHI Jingpu

Department of Clinical Epidemiology, the First Affiliated Hospital, China Medical University, Shenyang, 110001, P.R.China;

Corresponding?author：

SHI Jingpu, Email: sjp562013@126.com

Keywords：

ALOX5AP; Ischemic stroke; Polymorphism; Meta-analysis; Case-control study

DOI：

10.7507/1672-2531.201705087

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objectives To investigate the relationship between SG13S114 and SG13S32 polymorphisms in ALOX5AP gene and risk of ischemic stroke in Chinese population. Methods We searched Web of Science, EMbase, PubMed, CNKI, CBM and WanFang Data databases to collect case-control studies on SG13S114 and SG13S32 polymorphisms of ALOX5AP gene and risk of ischemic stroke in Chinese from inception to February 2017. Two reviewers independently screened literature, extracted data, and assessed the risk of bias of included studies. Meta-analysis was then performed by Stata 12.0 software. Results A total of 20 studies were included. The results of meta-analysis showed that SG13S114 polymorphism in ALOX5AP gene was associated with risk of ischemic stroke in Chinese (A vs. T: OR=1.12, 95%CI 1.00 to 1.27, P=0.05; TA+AA vs. TT: OR=1.14, 95%CI 1.01 to 1.28, P=0.04; AA vs. TT: OR=1.33, 95%CI 1.07 to 1.65, P=0.012). However, no significant association between SG13S32 polymorphism and ischemic stroke in Chinese was found. Conclusions SG13S114 polymorphisms in ALOX5AP gene is associated with risk of ischemic stroke in Chinese, in which the A allele of ALOX5AP may be a risk factor.

Citation： DAI Huixu, HE Qiao, LI Guangxiao, ZHANG Peng, SUN Hao, SHI Jingpu. Association of SG13S114 and SG13S32 polymorphisms in ALOX5AP gene and risk of ischemic stroke in Chinese: a meta-analysis . Chinese Journal of Evidence-Based Medicine, 2018, 18(1): 13-20. doi: 10.7507/1672-2531.201705087 Copy

1.	Wu X, Zhu B, Fu L, et al. Prevalence, incidence, and mortality of stroke in the Chinese island populations: a systematic review. PLoS One, 2013, 8(11): e78629.
2.	Wang W, Jiang B, Sun H, et al. Prevalence, incidence and mortality of stroke in China: results from a nationwide population-based survey of 480 687 adults. Circulation, 2017, 135(8): 759-771.
3.	Ke X, Wu X, Guo H, et al. Association of ALOX5AP rs10507391/SG13S114A>T polymorphism with cerebral infarction in the Chinese population: a meta-analysis study. Int J Neurosci, 2015, 125(10): 726-732.
4.	Flossmann E, Schulz UG, Rothwell PM, et al. Systematic review of methods and results of studies of the genentic epidemiology of ischemic stroke. Stroke, 2004, 35(1): 212-227.
5.	Linsel-Nitschke P, G?tz A, Medack A, et al. Genetic variation in the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) is associated with myocardial infarction in the German population. Clin Sci, 2008, 115(10): 309-315.
6.	Samuelsson B, Dahlen SE, Lindgren JA, et al. Leukotrienes and lipoxins: Structures, biosynthesis, and biological effects. Science, 1987, 237(4819): 1171-1176.
7.	Samuelsson B. Leukotrienes: Mediators of immediate hypersensitivity reactions and inflammation. Science, 1983, 220(4597): 568-575.
8.	Domingues-Montanari S, Fernandez-Cadenas I, del Rio-Espinola A, et al. Association of a genetic variant in the ALOX5AP with higher risk of ischemic stroke: a case control, meta-analysis and functional study. Cerebrovasc Dis, 2010, 29(6): 528-537.
9.	Zintzaras E, Rodopoulou P, Sakellaridis N. Variants of the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and risk of stroke: a huge gene-disease association review and meta-analysis. Am J Epidemiol, 2009, 169(5): 523-532.
10.	Ye F, Liu NN, Zheng YQ, et al. Three polymorphisms of ALOX5AP and risk of ischemic stroke in Chinese: evidence from a meta-analysis. J Neurol Sci, 2014, 336(1-2): 93-98.
11.	Wang G, Liu R, Zhang J. The arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene SG13S114 polymorphism and ischemic stroke in Chinese population: a meta-analysis. Gene, 2014, 533(2): 461-468.
12.	Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol, 2010, 25(9): 603-605.
13.	Yang Y, Zhang D, Feng N, et al. Increased intake of vegetables, but not fruit, reduces risk for hepatocellular carcinoma: a meta-analysis. Gastroenterology, 2014, 147(5): 1031-1042.
14.	Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics, 1994, 50(4): 1088-1101.
15.	Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ, 1997, 315(7109): 629-634.
16.	邵敏潔, 易興陽, 池麗芬. 浙江南部地區人群 5-脂氧合酶激活蛋白和磷酸二酯酶 4D 基因突變與缺血性腦卒中的研究. 中華老年心腦血管病雜志, 2013, 15(6): 592-595.
17.	馬建華. PDE4D、ALOX5AP 基因單核苷酸多態性與新疆維吾爾族、漢族腦梗死的相關性研究. 烏魯木齊: 新疆醫科大學, 2013.
18.	王劍南, 楊兆寧, 隋強. 5-脂氧合酶激活蛋白及磷酸二酯酶 4D 基因多態性與腦梗死易患性的分子流行病學研究. 蚌埠醫學院學報, 2015, 40(10): 1338-1340.
19.	吳海容. ALOX5AP 基因多態性與吸煙的交互作用對缺血性腦卒中的影響. 青島: 青島大學, 2013.
20.	何穎蕾, 朱敏, 金笑平, 等. ALOX5AP 基因 SG13S114A/T 多態性與動脈粥樣硬化性腦梗死的關系. 浙江大學學報, 2009, 38(6): 630-633.
21.	孫蕾, 李聰, 宋博, 等. ALOX5AP 基因多態性與缺血性腦卒中的相關性. 青島大學醫學院學報, 2012, 48(3): 207-210.
22.	徐佳亮. ALOX5AP 基因和 IL-1A 基因多態性與缺血性卒中的相關性. 沈陽: 中國醫科大學, 2009.
23.	姚倩倩, 周暢, 劉麗君, 等. ALOX5AP 基因多態性與動脈粥樣硬化性腦梗死相關性. 青島大學醫學院學報, 2013, 49(6): 471-475.
24.	高志嵩, 杜秦川. 缺血性腦卒中 ALOX5AP 基因 SG13S114T/A 和 SG13S89G/A 多態性研究. 寧夏醫學雜志, 2008, 30(5): 388-390.
25.	廖斷修, 易興陽, 張標, 等. ALOX5AP 和 CYP3A5 基因多態性與缺血性腦卒中后血栓事件的相關性. 西部醫學, 2016, 28(6): 823-828.
26.	池萬章, 易興陽, 黃雪融, 等. ALOX5AP 基因 SG13S114A/T 和 COX-2 基因 765G/C 交互作用增加腦梗死的易感性. 實用醫學雜志, 2014, 30(21): 3422-3425.
27.	馮學問, 吳偉林, 陳春友, 等. 5-脂氧合酶激活蛋白基因多態性與腦梗死易患性的臨床研究. 中國醫師雜志, 2016, 18(2): 212-215.
28.	高卓, 田國萍. 沈陽地區漢族人群腦梗死患者 ALOX5AP 基因 SNP 分析. 中風與神經疾病雜志, 2010, 27(11): 1022-1026.
29.	Zhang WL, Yang XM, Shi J, et al. Polymorphism of SG13S114T/A in the ALOX5AP gene and the risk for stroke in a large Chinese cohort. Acta Genetica Sinica, 2006, 33(8): 678-684.
30.	Xu C, Qiang L, Limei C, et al. Correlation between cerebral infarction and ALOX5AP gene expression. Cell Biochem Biophys, 2013, 67(3): 899-904.
31.	Yang D, He Y, Li M, et al. A novel risk haplotype of ALOX5AP gene is associated with ischemic stroke in Chinese Han population. J Mol Neurosci, 2014, 53(3): 493-499.
32.	Qu Z, Su F, Zhu Y, et al. A tagging ALOX5AP polymorphism and risk of ischemic stroke in a northeastern Chinese Han population. Int J Clin Exp Med, 2015, 8(11): 21343-21350.
33.	劉夢. 新疆維吾爾族缺血性腦卒中與 5-脂氧合酶激活蛋白基因 SG13S32 位點多態性的相關性研究. 烏魯木齊: 新疆醫科大學, 2015.
34.	李海先, 吳海容, 李建業, 等. ALOX5AP 基因多態性及肥胖與缺血性腦卒中相關性. 青島大學醫學院學報, 2013, 49(4): 319-325.
35.	池麗芬, 易興陽, 邵敏潔, 等. 5-脂氧合酶激活蛋白基因多態性與細胞色素 P450 酶 3A5 基因多態聯合交互作用顯著增加腦梗死風險. 中華神經科雜志, 2013, 46(8): 536-540.
36.	中華醫學會神經病學分會腦血管病學組缺血性腦卒中二級預防指南撰寫組. 中國缺血性腦卒中和短暫性腦缺血發作二級預防指南2010. 中華神經科雜志, 2010, 43(2): 154-160.
37.	He G, Ye S, Hui J, et al. Interrelationships between ALOX5AP polymorphisms, serum leukotriene B4 level and risk of acute coronary syndrome. PLoS One, 2014, 9(9): e106596.
38.	Mehrabian M, Allayee H, Wong J, et al. Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice. Circ Res, 2002, 91(2): 120-126.
39.	Spanbroek R, Grabner R, Lotzer K, et al. Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis. Proc Natl Acad Sci USA, 2003, 100(3): 1238-1243.
40.	Dwyer JH, Allayee H, Dwyer KM, et al. Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis. New Engl J Med, 2004, 350(1): 29-37.
41.	Aiello RJ, Bourassa PA, Lindsey S, et al. Leukotriene B4 receptor antagonism reduces monocytic foam cells in mice. Arterioscler Thromb Vasc Biol, 2002, 22(3): 443-449.
42.	Ghazalpour A, Wang X, Lusis AJ, et al. Complex inheritance of the 5-lipoxygenase locus influencing atherosclerosis in mice. Genetics, 2006, 173(2): 943-951.
43.	Chen Z, Zheng J, Liu W, et al. The SG13S114 polymorphism of the ALOX5AP gene is associated with ischemic stroke in Europeans: a meta-analysis of 8 062 subjects. Neurol Sci, 2017, 38(4): 579-587.

1. Wu X, Zhu B, Fu L, et al. Prevalence, incidence, and mortality of stroke in the Chinese island populations: a systematic review. PLoS One, 2013, 8(11): e78629.
2. Wang W, Jiang B, Sun H, et al. Prevalence, incidence and mortality of stroke in China: results from a nationwide population-based survey of 480 687 adults. Circulation, 2017, 135(8): 759-771.
3. Ke X, Wu X, Guo H, et al. Association of ALOX5AP rs10507391/SG13S114A>T polymorphism with cerebral infarction in the Chinese population: a meta-analysis study. Int J Neurosci, 2015, 125(10): 726-732.
4. Flossmann E, Schulz UG, Rothwell PM, et al. Systematic review of methods and results of studies of the genentic epidemiology of ischemic stroke. Stroke, 2004, 35(1): 212-227.
5. Linsel-Nitschke P, G?tz A, Medack A, et al. Genetic variation in the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) is associated with myocardial infarction in the German population. Clin Sci, 2008, 115(10): 309-315.
6. Samuelsson B, Dahlen SE, Lindgren JA, et al. Leukotrienes and lipoxins: Structures, biosynthesis, and biological effects. Science, 1987, 237(4819): 1171-1176.
7. Samuelsson B. Leukotrienes: Mediators of immediate hypersensitivity reactions and inflammation. Science, 1983, 220(4597): 568-575.
8. Domingues-Montanari S, Fernandez-Cadenas I, del Rio-Espinola A, et al. Association of a genetic variant in the ALOX5AP with higher risk of ischemic stroke: a case control, meta-analysis and functional study. Cerebrovasc Dis, 2010, 29(6): 528-537.
9. Zintzaras E, Rodopoulou P, Sakellaridis N. Variants of the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and risk of stroke: a huge gene-disease association review and meta-analysis. Am J Epidemiol, 2009, 169(5): 523-532.
10. Ye F, Liu NN, Zheng YQ, et al. Three polymorphisms of ALOX5AP and risk of ischemic stroke in Chinese: evidence from a meta-analysis. J Neurol Sci, 2014, 336(1-2): 93-98.
11. Wang G, Liu R, Zhang J. The arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene SG13S114 polymorphism and ischemic stroke in Chinese population: a meta-analysis. Gene, 2014, 533(2): 461-468.
12. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol, 2010, 25(9): 603-605.
13. Yang Y, Zhang D, Feng N, et al. Increased intake of vegetables, but not fruit, reduces risk for hepatocellular carcinoma: a meta-analysis. Gastroenterology, 2014, 147(5): 1031-1042.
14. Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics, 1994, 50(4): 1088-1101.
15. Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ, 1997, 315(7109): 629-634.
16. 邵敏潔, 易興陽, 池麗芬. 浙江南部地區人群 5-脂氧合酶激活蛋白和磷酸二酯酶 4D 基因突變與缺血性腦卒中的研究. 中華老年心腦血管病雜志, 2013, 15(6): 592-595.
17. 馬建華. PDE4D、ALOX5AP 基因單核苷酸多態性與新疆維吾爾族、漢族腦梗死的相關性研究. 烏魯木齊: 新疆醫科大學, 2013.
18. 王劍南, 楊兆寧, 隋強. 5-脂氧合酶激活蛋白及磷酸二酯酶 4D 基因多態性與腦梗死易患性的分子流行病學研究. 蚌埠醫學院學報, 2015, 40(10): 1338-1340.
19. 吳海容. ALOX5AP 基因多態性與吸煙的交互作用對缺血性腦卒中的影響. 青島: 青島大學, 2013.
20. 何穎蕾, 朱敏, 金笑平, 等. ALOX5AP 基因 SG13S114A/T 多態性與動脈粥樣硬化性腦梗死的關系. 浙江大學學報, 2009, 38(6): 630-633.
21. 孫蕾, 李聰, 宋博, 等. ALOX5AP 基因多態性與缺血性腦卒中的相關性. 青島大學醫學院學報, 2012, 48(3): 207-210.
22. 徐佳亮. ALOX5AP 基因和 IL-1A 基因多態性與缺血性卒中的相關性. 沈陽: 中國醫科大學, 2009.
23. 姚倩倩, 周暢, 劉麗君, 等. ALOX5AP 基因多態性與動脈粥樣硬化性腦梗死相關性. 青島大學醫學院學報, 2013, 49(6): 471-475.
24. 高志嵩, 杜秦川. 缺血性腦卒中 ALOX5AP 基因 SG13S114T/A 和 SG13S89G/A 多態性研究. 寧夏醫學雜志, 2008, 30(5): 388-390.
25. 廖斷修, 易興陽, 張標, 等. ALOX5AP 和 CYP3A5 基因多態性與缺血性腦卒中后血栓事件的相關性. 西部醫學, 2016, 28(6): 823-828.
26. 池萬章, 易興陽, 黃雪融, 等. ALOX5AP 基因 SG13S114A/T 和 COX-2 基因 765G/C 交互作用增加腦梗死的易感性. 實用醫學雜志, 2014, 30(21): 3422-3425.
27. 馮學問, 吳偉林, 陳春友, 等. 5-脂氧合酶激活蛋白基因多態性與腦梗死易患性的臨床研究. 中國醫師雜志, 2016, 18(2): 212-215.
28. 高卓, 田國萍. 沈陽地區漢族人群腦梗死患者 ALOX5AP 基因 SNP 分析. 中風與神經疾病雜志, 2010, 27(11): 1022-1026.
29. Zhang WL, Yang XM, Shi J, et al. Polymorphism of SG13S114T/A in the ALOX5AP gene and the risk for stroke in a large Chinese cohort. Acta Genetica Sinica, 2006, 33(8): 678-684.
30. Xu C, Qiang L, Limei C, et al. Correlation between cerebral infarction and ALOX5AP gene expression. Cell Biochem Biophys, 2013, 67(3): 899-904.
31. Yang D, He Y, Li M, et al. A novel risk haplotype of ALOX5AP gene is associated with ischemic stroke in Chinese Han population. J Mol Neurosci, 2014, 53(3): 493-499.
32. Qu Z, Su F, Zhu Y, et al. A tagging ALOX5AP polymorphism and risk of ischemic stroke in a northeastern Chinese Han population. Int J Clin Exp Med, 2015, 8(11): 21343-21350.
33. 劉夢. 新疆維吾爾族缺血性腦卒中與 5-脂氧合酶激活蛋白基因 SG13S32 位點多態性的相關性研究. 烏魯木齊: 新疆醫科大學, 2015.
34. 李海先, 吳海容, 李建業, 等. ALOX5AP 基因多態性及肥胖與缺血性腦卒中相關性. 青島大學醫學院學報, 2013, 49(4): 319-325.
35. 池麗芬, 易興陽, 邵敏潔, 等. 5-脂氧合酶激活蛋白基因多態性與細胞色素 P450 酶 3A5 基因多態聯合交互作用顯著增加腦梗死風險. 中華神經科雜志, 2013, 46(8): 536-540.
36. 中華醫學會神經病學分會腦血管病學組缺血性腦卒中二級預防指南撰寫組. 中國缺血性腦卒中和短暫性腦缺血發作二級預防指南2010. 中華神經科雜志, 2010, 43(2): 154-160.
37. He G, Ye S, Hui J, et al. Interrelationships between ALOX5AP polymorphisms, serum leukotriene B4 level and risk of acute coronary syndrome. PLoS One, 2014, 9(9): e106596.
38. Mehrabian M, Allayee H, Wong J, et al. Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice. Circ Res, 2002, 91(2): 120-126.
39. Spanbroek R, Grabner R, Lotzer K, et al. Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis. Proc Natl Acad Sci USA, 2003, 100(3): 1238-1243.
40. Dwyer JH, Allayee H, Dwyer KM, et al. Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis. New Engl J Med, 2004, 350(1): 29-37.
41. Aiello RJ, Bourassa PA, Lindsey S, et al. Leukotriene B4 receptor antagonism reduces monocytic foam cells in mice. Arterioscler Thromb Vasc Biol, 2002, 22(3): 443-449.
42. Ghazalpour A, Wang X, Lusis AJ, et al. Complex inheritance of the 5-lipoxygenase locus influencing atherosclerosis in mice. Genetics, 2006, 173(2): 943-951.
43. Chen Z, Zheng J, Liu W, et al. The SG13S114 polymorphism of the ALOX5AP gene is associated with ischemic stroke in Europeans: a meta-analysis of 8 062 subjects. Neurol Sci, 2017, 38(4): 579-587.

Chinese Journal of Evidence-Based Medicine

Association of SG13S114 and SG13S32 polymorphisms in ALOX5AP gene and risk of ischemic stroke in Chinese: a meta-analysis

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