癲癇合并阻塞性睡眠呼吸暫停綜合征相關危險因素的研究進展_Journal of Epilepsy

Authors：

王芬 ¹ , 丁勇民 ¹ , 羅新明 ² ,  張明 ²

1. ;
2. ;

Corresponding?author：

張明, Email: 13177801250@sina.com

Keywords：

癲癇; 阻塞性睡眠呼吸暫停綜合征; 相關性; 危險因素

DOI：

10.7507/2096-0247.20180056

Video：

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癲癇是多種原因導致的腦部神經元高度同步化異常放電的臨床綜合征。阻塞性睡眠呼吸暫停綜合征（Obstructive sleep apnea syndrome，OSAS）是一種病因不明的睡眠呼吸疾病，臨床表現有夜間睡眠打鼾伴呼吸暫停和白天嗜睡，呼吸暫停可引起反復發作的夜間低氧血癥和高碳酸血癥。越來越多研究證明，癲癇患者中 OSAS 的發病率遠遠高于正常人群，兩病共患具有治療難及預后差的特點。夜間反復呼吸暫停會導致睡眠片段化和睡眠剝奪，可能是導致癲癇患者難治的原因之一。現對癲癇合并 OSAS 的相關危險因素進行總結。

Citation： 王芬, 丁勇民, 羅新明, 張明. 癲癇合并阻塞性睡眠呼吸暫停綜合征相關危險因素的研究進展. Journal of Epilepsy, 2018, 4(4): 340-343. doi: 10.7507/2096-0247.20180056 Copy

1.	Redline S, Tishler PV, Schluchter M, et al. Risk factors for sleep-disordered breathing in children. Associations with obesity, race, and respiratory problems. Am J Respir Crit Care Med, 1999, 159(5 Pt 1): 1527-1532.
2.	劉涵, 肖爭. 癲癇與阻塞性睡眠呼吸暫停綜合征的關系. 癲癇雜志, 2017, 3(6): 505-508.
3.	Hoch CC, Reynolds CR, Monk TH, et al. Comparison of sleep-disordered breathing among healthy elderly in the seventh, eighth, and ninth decades of life. Sleep, 1990, 13(6): 502-511.
4.	Manni R, Terzaghi M, Arbasino C, et al. Obstructive sleep apnea in a clinical series of adult epilepsy patients: frequency and features of the comorbidity. Epilepsia, 2003, 44(6): 836-840.
5.	Malow BA, Levy K, Maturen K, et al. Obstructive sleep apnea is common in medically refractory epilepsy patients. Neurology, 2000, 55(7): 1002-1007.
6.	Jain SV, Simakajornboon S, Shapiro SM, et al. Obstructive sleep apnea in children with epilepsy: prospective pilot trial. Acta Neurol Scand, 2012, 125(1): e3-e6.
7.	Maurousset A, De Toffol B, Praline J, et al. High incidence of obstructive sleep apnea syndrome in patients with late-onset epilepsy. Neurophysiol Clin, 2017, 47(1): 55-61.
8.	Rosenzweig I, Glasser M, Polsek D, et al. Sleep apnoea and the brain: a complex relationship. Lancet Respir Med, 2015, 3(5): 404-414.
9.	V Dinkelacker. Obstructive sleep apnea in drug-resistant epilepsy:A significant comorbidity warranting diagnosis and treatment. Rev Neurol (Paris), 2016, 172(6-7): 361-370.
10.	Nishibayashi M, Miyamoto M, Miyamoto T, et al. Correlation between severity of obstructive sleep apnea and prevalence of silent cerebrovascular lesions. J Clin Sleep Med, 2008, 4(3): 242-247.
11.	Derry CP, Duncan S. Sleep and epilepsy. Epilepsy Behav, 2013, 26(3): 394-404.
12.	Parrino L, Grassi A, Milioli G. Cyclic alternating pattern in polysomnography: what is it and what does it mean?. Curr Opin Pulm Med, 2014, 20(6): 533-541.
13.	Ferini-Strambi L, Galbiati A, Marelli S. Sleep microstructure and memory function. Front Neurol, 2013, 4: 159.
14.	Halasz P, Kelemen A, Szucs A. The role of NREM sleep micro-arousals in absence epilepsy and in nocturnal frontal lobe epilepsy. Epilepsy Res, 2013, 107(1-2): 9-19.
15.	Terzano MG, Parrino L, Boselli M, et al. Polysomnographic analysis of arousal responses in obstructive sleep apnea syndrome by means of the cyclic alternating pattern. J Clin Neurophysiol, 1996, 13(2): 145-155.
16.	Milioli G, Bosi M, Grassi A, et al. Can sleep microstructure improve diagnosis of OSASS? Integrative information from CAP parameters. Arch Ital Biol, 2015, 153(2-3): 194-203.
17.	Pornsriniyom D, Shinlapawittayatorn K, Fong J, et al. Continuous positive airway pressure therapy for obstructive sleep apnea reduces interictal epileptiform discharges in adults with epilepsy. Epilepsy Behav, 2014, 37: 171-174.
18.	Foldvary-Schaefer N, Stephenson L, Bingaman W. Resolution of obstructive sleep apnea with epilepsy surgery? Expanding the relationship between sleep and epilepsy. Epilepsia, 2008, 49(8): 1457-1459.
19.	Manni R, Terzaghi M. Comorbidity between epilepsy and sleep disorders. Epilepsy Res, 2010, 90(3): 171-177.
20.	Maurousset A, De Toffol B, Praline J, et al. High incidence of obstructive sleep apnea syndrome in patients with late-onset epilepsy. Neurophysiol Clin, 2017, 47(1): 55-61.
21.	Lambert MV, Bird JM. Obstructive sleep apnoea following rapid weight gain secondary to treatment with vigabatrin (Sabril). Seizure, 1997, 6(3): 233-235.
22.	Foldvary-Schaefer N, Grigg-Damberger M. Sleep and epilepsy. Semin Neurol, 2009, 29(4): 419-428.
23.	Malow BA, Levy K, Maturen K, et al. Obstructive sleep apnea is common in medically refractory epilepsy patients. Neurology, 2000, 55(7): 1002-1007.
24.	Chihorek AM, Abou-Khalil B, Malow BA. Obstructive sleep apnea is associated with seizure occurrence in older adults with epilepsy. Neurology, 2007, 69(19): 1823-1827.
25.	Li P, Ghadersohi S, Jafari B, et al. Characteristics of refractory vs. medically controlled epilepsy patients with obstructive sleep apnea and their response to CPAP treatment. Seizure, 2012, 21(9): 717-721.
26.	Sonka K, Juklickova M, Pretl M, et al. Seizures in sleep apnea patients: occurrence and time distribution. Sb Lek, 2000, 101(3): 229-232.
27.	Bazil CW. Effects of antiepileptic drugs on sleep structure : are all drugs equal?. CNS Drugs, 2003, 17(10): 719-728.
28.	Takhar J, Bishop J. Influence of chronic barbiturate administration on sleep apnea after hypersomnia presentation: case study. J Psychiatry Neurosci, 2000, 25(4): 321-324.
29.	Giordano F, Zicca A, Barba C, et al. Vagus nerve stimulation: Surgical technique of implantation and revision and related morbidity. Epilepsia, 2017, 58(Suppl 1): 85-90.
30.	Zambrelli E, Saibene AM, Furia F, et al. Laryngeal motility alteration: A missing link between sleep apnea and vagus nerve stimulation for epilepsy. Epilepsia, 2016, 57(1): e24-e27.
31.	Parhizgar F, Nugent K, Raj R. Obstructive sleep apnea and respiratory complications associated with vagus nerve stimulators. J Clin Sleep Med, 2011, 7(4): 401-407.
32.	Ebben MR, Sethi NK, Conte M, et al. Vagus nerve stimulation, sleep apnea, and CPAP titration. J Clin Sleep Med, 2008, 4(5): 471-473.
33.	Gschliesser V, Hogl B, Frauscher B, et al. Mode of vagus nerve stimulation differentially affects sleep related breathing in patients with epilepsy. Seizure, 2009, 18(5): 339-342.
34.	Malow BA, Edwards J, Marzec M, et al. Effects of vagus nerve stimulation on respiration during sleep: a pilot study. Neurology, 2000, 55(10): 1450-1454.

1. Redline S, Tishler PV, Schluchter M, et al. Risk factors for sleep-disordered breathing in children. Associations with obesity, race, and respiratory problems. Am J Respir Crit Care Med, 1999, 159(5 Pt 1): 1527-1532.
2. 劉涵, 肖爭. 癲癇與阻塞性睡眠呼吸暫停綜合征的關系. 癲癇雜志, 2017, 3(6): 505-508.
3. Hoch CC, Reynolds CR, Monk TH, et al. Comparison of sleep-disordered breathing among healthy elderly in the seventh, eighth, and ninth decades of life. Sleep, 1990, 13(6): 502-511.
4. Manni R, Terzaghi M, Arbasino C, et al. Obstructive sleep apnea in a clinical series of adult epilepsy patients: frequency and features of the comorbidity. Epilepsia, 2003, 44(6): 836-840.
5. Malow BA, Levy K, Maturen K, et al. Obstructive sleep apnea is common in medically refractory epilepsy patients. Neurology, 2000, 55(7): 1002-1007.
6. Jain SV, Simakajornboon S, Shapiro SM, et al. Obstructive sleep apnea in children with epilepsy: prospective pilot trial. Acta Neurol Scand, 2012, 125(1): e3-e6.
7. Maurousset A, De Toffol B, Praline J, et al. High incidence of obstructive sleep apnea syndrome in patients with late-onset epilepsy. Neurophysiol Clin, 2017, 47(1): 55-61.
8. Rosenzweig I, Glasser M, Polsek D, et al. Sleep apnoea and the brain: a complex relationship. Lancet Respir Med, 2015, 3(5): 404-414.
9. V Dinkelacker. Obstructive sleep apnea in drug-resistant epilepsy:A significant comorbidity warranting diagnosis and treatment. Rev Neurol (Paris), 2016, 172(6-7): 361-370.
10. Nishibayashi M, Miyamoto M, Miyamoto T, et al. Correlation between severity of obstructive sleep apnea and prevalence of silent cerebrovascular lesions. J Clin Sleep Med, 2008, 4(3): 242-247.
11. Derry CP, Duncan S. Sleep and epilepsy. Epilepsy Behav, 2013, 26(3): 394-404.
12. Parrino L, Grassi A, Milioli G. Cyclic alternating pattern in polysomnography: what is it and what does it mean?. Curr Opin Pulm Med, 2014, 20(6): 533-541.
13. Ferini-Strambi L, Galbiati A, Marelli S. Sleep microstructure and memory function. Front Neurol, 2013, 4: 159.
14. Halasz P, Kelemen A, Szucs A. The role of NREM sleep micro-arousals in absence epilepsy and in nocturnal frontal lobe epilepsy. Epilepsy Res, 2013, 107(1-2): 9-19.
15. Terzano MG, Parrino L, Boselli M, et al. Polysomnographic analysis of arousal responses in obstructive sleep apnea syndrome by means of the cyclic alternating pattern. J Clin Neurophysiol, 1996, 13(2): 145-155.
16. Milioli G, Bosi M, Grassi A, et al. Can sleep microstructure improve diagnosis of OSASS? Integrative information from CAP parameters. Arch Ital Biol, 2015, 153(2-3): 194-203.
17. Pornsriniyom D, Shinlapawittayatorn K, Fong J, et al. Continuous positive airway pressure therapy for obstructive sleep apnea reduces interictal epileptiform discharges in adults with epilepsy. Epilepsy Behav, 2014, 37: 171-174.
18. Foldvary-Schaefer N, Stephenson L, Bingaman W. Resolution of obstructive sleep apnea with epilepsy surgery? Expanding the relationship between sleep and epilepsy. Epilepsia, 2008, 49(8): 1457-1459.
19. Manni R, Terzaghi M. Comorbidity between epilepsy and sleep disorders. Epilepsy Res, 2010, 90(3): 171-177.
20. Maurousset A, De Toffol B, Praline J, et al. High incidence of obstructive sleep apnea syndrome in patients with late-onset epilepsy. Neurophysiol Clin, 2017, 47(1): 55-61.
21. Lambert MV, Bird JM. Obstructive sleep apnoea following rapid weight gain secondary to treatment with vigabatrin (Sabril). Seizure, 1997, 6(3): 233-235.
22. Foldvary-Schaefer N, Grigg-Damberger M. Sleep and epilepsy. Semin Neurol, 2009, 29(4): 419-428.
23. Malow BA, Levy K, Maturen K, et al. Obstructive sleep apnea is common in medically refractory epilepsy patients. Neurology, 2000, 55(7): 1002-1007.
24. Chihorek AM, Abou-Khalil B, Malow BA. Obstructive sleep apnea is associated with seizure occurrence in older adults with epilepsy. Neurology, 2007, 69(19): 1823-1827.
25. Li P, Ghadersohi S, Jafari B, et al. Characteristics of refractory vs. medically controlled epilepsy patients with obstructive sleep apnea and their response to CPAP treatment. Seizure, 2012, 21(9): 717-721.
26. Sonka K, Juklickova M, Pretl M, et al. Seizures in sleep apnea patients: occurrence and time distribution. Sb Lek, 2000, 101(3): 229-232.
27. Bazil CW. Effects of antiepileptic drugs on sleep structure : are all drugs equal?. CNS Drugs, 2003, 17(10): 719-728.
28. Takhar J, Bishop J. Influence of chronic barbiturate administration on sleep apnea after hypersomnia presentation: case study. J Psychiatry Neurosci, 2000, 25(4): 321-324.
29. Giordano F, Zicca A, Barba C, et al. Vagus nerve stimulation: Surgical technique of implantation and revision and related morbidity. Epilepsia, 2017, 58(Suppl 1): 85-90.
30. Zambrelli E, Saibene AM, Furia F, et al. Laryngeal motility alteration: A missing link between sleep apnea and vagus nerve stimulation for epilepsy. Epilepsia, 2016, 57(1): e24-e27.
31. Parhizgar F, Nugent K, Raj R. Obstructive sleep apnea and respiratory complications associated with vagus nerve stimulators. J Clin Sleep Med, 2011, 7(4): 401-407.
32. Ebben MR, Sethi NK, Conte M, et al. Vagus nerve stimulation, sleep apnea, and CPAP titration. J Clin Sleep Med, 2008, 4(5): 471-473.
33. Gschliesser V, Hogl B, Frauscher B, et al. Mode of vagus nerve stimulation differentially affects sleep related breathing in patients with epilepsy. Seizure, 2009, 18(5): 339-342.
34. Malow BA, Edwards J, Marzec M, et al. Effects of vagus nerve stimulation on respiration during sleep: a pilot study. Neurology, 2000, 55(10): 1450-1454.

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