【摘要】　目的　 了解圍手術期預防性應用抗菌藥物的現狀并評價其合理性。　方法　 采用回顧性調查的方法，隨機抽查2009年1-12月500例Ⅰ類切口圍手術期患者資料，填寫設計的《外科圍手術期預防性應用抗菌藥物調查表》，對預防用藥的適應證、用藥種類、聯合用藥、給藥時機及持續時間進行統計分析。　結果　 500例中，未使用抗菌藥物5例，預防性使用抗菌藥物495例，不合理或欠合理80例（16.00%）。預防性使用抗菌藥物總例次為540，其中頭孢菌素類453例次（83.89%），青霉素類（包括酶抑制劑）26例次（4.81%），喹諾酮類44例次（8.15%），林可酰胺類17例次（3.15%）。頭孢唑啉鈉使用178例次（32.96%）居第1位，頭孢替唑鈉使用151例次（27.96%）。　結論　 Ⅰ類切口手術圍手術期預防性使用抗菌藥物較為合理，但仍存在用藥指征把握不嚴，抗菌藥物的選擇、使用時間較長等問題，有待進一步規范化管理。
【Abstract】　Objective　 To evaluate the prophylactic application of antibiotics during the perioperative period of type I incisions.　Methods　 The clinical data of 500 patients with type I incisions from January to December of 2009 were retrospectively analyzed by self-designed questionnaire survey. The indication of antibiotics usage, choice of antibiotics categories, combination of antibiotics,giving time and length of antibiotics usage were analyzed.　Results　 In 500 patients, only 5 were not given antibiotics, 80 (16%) were given antibiotics unnecessarily. In 540 patients who had underwent the antibiotic administration, 453 (16%) were administrated with cephalosporins, 44 (8.15%) were with fluoroquinolones, 26 (4.81%) were with penicillins, and 17 (3.15%) were with lincomycins. Cefazolin, the most used antibiotics, was given in 178 patients (32.96%)。Ceftezole was given in 151 patients (27.96%). 　Conclusion　 The prophylactic application of antibiotics during the perioperative period of type I incisions is basically rational, however, there were also some problems, such as using antibiotics unnecessary, mischoice of antibiotics and using antibiotics too long. Thus, we need management of prophylactic antibiotics usage.

引用本文： 王仲書,蘭文英. 圍手術期預防性應用抗菌藥物的調查與分析. 華西醫學, 2010, 25(12): 2241-2243. doi: 復制